Incidental Mutation 'R8275:Vmn1r220'
ID637953
Institutional Source Beutler Lab
Gene Symbol Vmn1r220
Ensembl Gene ENSMUSG00000096099
Gene Namevomeronasal 1 receptor 220
SynonymsV1rh12
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.188) question?
Stock #R8275 (G1)
Quality Score225.009
Status Validated
Chromosome13
Chromosomal Location23178514-23187975 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 23184313 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Stop codon at position 71 (L71*)
Ref Sequence ENSEMBL: ENSMUSP00000072222 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072385]
Predicted Effect probably null
Transcript: ENSMUST00000072385
AA Change: L71*
SMART Domains Protein: ENSMUSP00000072222
Gene: ENSMUSG00000096099
AA Change: L71*

DomainStartEndE-ValueType
Pfam:V1R 33 297 5e-38 PFAM
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap2 T C 4: 57,886,329 probably null Het
Alx1 T C 10: 103,028,389 D73G probably benign Het
Asah1 G A 8: 41,348,122 H156Y probably damaging Het
Cgn G A 3: 94,774,953 L439F possibly damaging Het
Creb1 C A 1: 64,558,528 T7K probably benign Het
Cyp2c54 T A 19: 40,038,305 I469L probably benign Het
Cyp2s1 T A 7: 25,809,310 T236S probably benign Het
Duox1 T C 2: 122,344,768 I1349T probably benign Het
Efhd2 C T 4: 141,874,762 A36T probably benign Het
Espl1 G A 15: 102,302,753 probably benign Het
Fan1 T A 7: 64,372,486 N340Y probably damaging Het
Fat3 T A 9: 16,246,750 Q1188L probably damaging Het
Flt1 A T 5: 147,678,147 Y330N probably damaging Het
Golga4 A T 9: 118,532,559 S202C probably damaging Het
Htr2b C T 1: 86,102,572 D134N probably damaging Het
Katna1 T A 10: 7,752,810 C268S probably damaging Het
Lama4 T C 10: 39,072,811 Y857H probably damaging Het
Lyst T C 13: 13,776,082 I3741T probably benign Het
Mcm4 T C 16: 15,634,571 I233V probably damaging Het
Mettl22 T C 16: 8,485,928 V286A possibly damaging Het
Nav3 C A 10: 109,692,123 G1503V noncoding transcript Het
Obox1 T A 7: 15,556,228 N165K probably damaging Het
Olfr744 T A 14: 50,618,411 M63K probably damaging Het
Oxa1l T A 14: 54,363,301 I77N possibly damaging Het
Papss2 T C 19: 32,638,360 L164P probably damaging Het
Pikfyve T A 1: 65,253,342 probably benign Het
Polr2a G A 11: 69,748,056 R51C probably damaging Het
Rsph10b C G 5: 143,966,505 T606S possibly damaging Het
Siglecg T C 7: 43,412,468 V546A probably benign Het
Slc22a29 T C 19: 8,169,317 S374G probably benign Het
Tia1 C T 6: 86,427,736 Q318* probably null Het
Trpm2 T A 10: 77,966,025 K69* probably null Het
Unc80 C T 1: 66,640,614 R2115* probably null Het
Usp35 A G 7: 97,314,819 S436P probably damaging Het
Vmn2r15 A T 5: 109,286,284 D851E probably benign Het
Vps33a A T 5: 123,569,459 D148E probably damaging Het
Zfp729a G A 13: 67,620,104 H669Y probably benign Het
Zfp804b C T 5: 6,772,289 R258Q probably benign Het
Other mutations in Vmn1r220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Vmn1r220 APN 13 23184477 missense probably null 0.01
IGL00953:Vmn1r220 APN 13 23183765 missense probably benign 0.00
IGL00972:Vmn1r220 APN 13 23184388 missense probably damaging 1.00
IGL01511:Vmn1r220 APN 13 23184214 missense probably damaging 1.00
IGL02967:Vmn1r220 APN 13 23183992 missense probably damaging 0.97
IGL03040:Vmn1r220 APN 13 23183782 missense possibly damaging 0.92
R1226:Vmn1r220 UTSW 13 23184124 missense probably damaging 1.00
R1869:Vmn1r220 UTSW 13 23184287 missense probably damaging 1.00
R2312:Vmn1r220 UTSW 13 23183977 missense probably damaging 1.00
R4223:Vmn1r220 UTSW 13 23183978 missense probably benign 0.22
R5655:Vmn1r220 UTSW 13 23184128 missense probably benign 0.03
R6188:Vmn1r220 UTSW 13 23183914 missense probably damaging 1.00
R6276:Vmn1r220 UTSW 13 23184295 missense probably damaging 1.00
R7756:Vmn1r220 UTSW 13 23183707 missense probably benign 0.25
R8867:Vmn1r220 UTSW 13 23184101 missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- TGTGCCATGCAGACTTTGGC -3'
(R):5'- TTTTCAGATCCATGTCTGGCATTAC -3'

Sequencing Primer
(F):5'- CATGCAGACTTTGGCCTGAG -3'
(R):5'- GATCCATGTCTGGCATTACTAATAC -3'
Posted On2020-07-28