Incidental Mutation 'R8276:Trav7-6'
ID637993
Institutional Source Beutler Lab
Gene Symbol Trav7-6
Ensembl Gene ENSMUSG00000096138
Gene NameT cell receptor alpha variable 7-6
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.104) question?
Stock #R8276 (G1)
Quality Score225.009
Status Not validated
Chromosome14
Chromosomal Location53716716-53717290 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 53717238 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 95 (H95L)
Ref Sequence ENSEMBL: ENSMUSP00000100418 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103641] [ENSMUST00000184687]
Predicted Effect probably benign
Transcript: ENSMUST00000103641
AA Change: H95L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000100418
Gene: ENSMUSG00000096138
AA Change: H95L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IGv 38 111 8.57e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000184687
AA Change: H75L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000139015
Gene: ENSMUSG00000096138
AA Change: H75L

DomainStartEndE-ValueType
IGv 18 91 8.57e-12 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,663,928 R27W probably damaging Het
9430020K01Rik T A 18: 4,674,318 S693R probably damaging Het
Acbd5 A G 2: 23,069,551 D39G probably benign Het
Amdhd2 C G 17: 24,163,600 R22P probably damaging Het
Ankmy1 T C 1: 92,886,809 I325M probably benign Het
Cyld A G 8: 88,734,928 I664M probably benign Het
Dnajc10 T C 2: 80,349,270 M716T probably benign Het
Dock10 T A 1: 80,528,281 T1743S probably benign Het
Dopey1 T C 9: 86,517,039 S947P probably benign Het
Ep300 C G 15: 81,650,028 N2095K possibly damaging Het
Evi2a T A 11: 79,527,490 N98I probably damaging Het
Fan1 T A 7: 64,372,486 N340Y probably damaging Het
Far2 G T 6: 148,173,901 V420L probably benign Het
Heatr5b G A 17: 78,791,539 R1311* probably null Het
Hhipl2 A T 1: 183,436,419 K478M possibly damaging Het
Hs3st1 A T 5: 39,614,803 Y166N probably damaging Het
Kcnmb3 A G 3: 32,482,423 L52P probably damaging Het
Mib1 T C 18: 10,751,880 I254T possibly damaging Het
Myo18b T C 5: 112,795,407 K1644R possibly damaging Het
Nlrp2 G A 7: 5,317,495 T881M probably benign Het
Olfr651 A T 7: 104,553,315 Y132F probably damaging Het
Olfr748 T A 14: 50,710,830 S167T probably benign Het
Pkd1l3 A C 8: 109,670,721 *2152C probably null Het
Polr2a G A 11: 69,748,056 R51C probably damaging Het
Ptpru C T 4: 131,779,173 G1026D probably damaging Het
Rbm46 A G 3: 82,864,588 V240A probably damaging Het
Rrm1 G A 7: 102,460,852 probably null Het
Ryr3 T C 2: 112,640,617 D4637G probably damaging Het
Serpina1e G T 12: 103,947,169 T364K probably damaging Het
Shroom3 A T 5: 92,940,480 Q363L probably damaging Het
Slc9a3r2 G T 17: 24,642,260 Y175* probably null Het
Slc9b1 A C 3: 135,371,897 E139D possibly damaging Het
Tmcc3 A T 10: 94,582,308 T344S probably damaging Het
Tnrc6b T A 15: 80,880,717 S807T probably benign Het
Trmu T A 15: 85,882,731 V47D possibly damaging Het
Unc79 A G 12: 103,001,863 D116G possibly damaging Het
Vmn2r93 G A 17: 18,305,387 probably null Het
Zfp541 A T 7: 16,079,084 H554L possibly damaging Het
Zfp618 A G 4: 63,132,956 H658R probably damaging Het
Zmym1 A T 4: 127,054,258 Y107N probably damaging Het
Other mutations in Trav7-6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01320:Trav7-6 APN 14 53717108 missense possibly damaging 0.81
R0100:Trav7-6 UTSW 14 53717072 missense probably damaging 1.00
R3023:Trav7-6 UTSW 14 53717244 missense probably benign
R4020:Trav7-6 UTSW 14 53717181 missense probably benign 0.19
R5049:Trav7-6 UTSW 14 53717079 missense probably damaging 0.97
R7512:Trav7-6 UTSW 14 53717095 missense probably benign 0.22
R8205:Trav7-6 UTSW 14 53717093 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGAGCCCAGAATCCCTCATTG -3'
(R):5'- AGTGGCTCTCAACTCCCATTAC -3'

Sequencing Primer
(F):5'- GAATCCCTCATTGTCCCAGAGG -3'
(R):5'- TCAACTCCCATTACATGTGGAGG -3'
Posted On2020-07-28