Mutagenetix > Incidental Mutation

Incidental Mutation 'R8277:Or1p1b'

638039

Institutional Source

Beutler Lab

Gene Symbol

Or1p1b

Ensembl Gene

ENSMUSG00000083188

Gene Name

olfactory receptor family 1 subfamily P member 1B

Synonyms

MOR133-5P, Olfr404-ps1, GA_x6K02T2P1NL-4385196-4386167

MMRRC Submission

067700-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R8277 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

74130392-74131330 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 74130842 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 151 (L151F)

Ref Sequence

ENSEMBL: ENSMUSP00000146326 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000121065]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000121065
AA Change: L151F

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	A	19: 57,204,351 (GRCm39)	L13F	probably benign	Het
Apoe	C	T	7: 19,432,303 (GRCm39)		probably benign	Het
Arap2	A	G	5: 62,771,335 (GRCm39)		probably null	Het
Aspm	T	C	1: 139,382,748 (GRCm39)	S27P	probably damaging	Het
Atcay	C	A	10: 81,050,646 (GRCm39)	D90Y	probably damaging	Het
Cd46	A	T	1: 194,747,030 (GRCm39)	D327E	probably damaging	Het
Cfh	A	G	1: 140,029,347 (GRCm39)	W1001R	probably damaging	Het
Chrm2	G	A	6: 36,500,211 (GRCm39)	V23M	probably benign	Het
Col1a2	G	A	6: 4,516,410 (GRCm39)	G175R	probably null	Het
Ddx52	T	C	11: 83,845,940 (GRCm39)	S422P	probably damaging	Het
Dync2i2	A	G	2: 29,923,886 (GRCm39)	V213A	probably benign	Het
Entr1	G	A	2: 26,274,778 (GRCm39)	A373V	probably damaging	Het
Gucy2d	T	A	7: 98,092,682 (GRCm39)	W20R	probably benign	Het
Hao2	A	G	3: 98,787,700 (GRCm39)	I243T	probably damaging	Het
Hmcn2	A	C	2: 31,259,189 (GRCm39)	T1010P	probably benign	Het
Iqcf1	T	C	9: 106,379,077 (GRCm39)	S29P	probably benign	Het
Kat2b	T	A	17: 53,948,281 (GRCm39)	D350E	probably benign	Het
Lingo4	A	G	3: 94,309,931 (GRCm39)	S290G	possibly damaging	Het
Mmrn1	A	G	6: 60,954,220 (GRCm39)	T834A	probably benign	Het
Mro	A	T	18: 73,997,132 (GRCm39)		probably benign	Het
Mrps26	T	A	2: 130,406,347 (GRCm39)	L160Q	probably damaging	Het
Myh8	T	C	11: 67,183,735 (GRCm39)	I788T	probably benign	Het
Nab2	G	A	10: 127,501,168 (GRCm39)		probably benign	Het
Nr2c2ap	C	T	8: 70,585,131 (GRCm39)	Q67*	probably null	Het
Pask	C	T	1: 93,253,085 (GRCm39)		probably null	Het
Pcnx2	A	T	8: 126,592,755 (GRCm39)	S736R	probably damaging	Het
Per2	G	T	1: 91,348,274 (GRCm39)	D1109E	probably benign	Het
Plxna1	G	A	6: 89,334,162 (GRCm39)	H156Y	probably damaging	Het
Polr2a	G	A	11: 69,638,882 (GRCm39)	R51C	probably damaging	Het
Rbpms2	T	A	9: 65,556,695 (GRCm39)	F45Y	probably damaging	Het
Rmdn3	T	C	2: 118,976,905 (GRCm39)	D276G	probably damaging	Het
Septin2	T	A	1: 93,427,030 (GRCm39)	I171K	probably benign	Het
Serpinb3a	C	A	1: 106,973,970 (GRCm39)	G314C	probably damaging	Het
Slc35f3	T	A	8: 127,115,925 (GRCm39)	V284D	possibly damaging	Het
Snapc4	A	G	2: 26,255,722 (GRCm39)	V934A	probably benign	Het
Tctn1	A	G	5: 122,402,431 (GRCm39)	M1T	probably null	Het
Tgoln1	G	A	6: 72,593,838 (GRCm39)		probably benign	Het
Unc5c	G	A	3: 141,474,373 (GRCm39)		probably null	Het
Vmn2r11	A	T	5: 109,202,833 (GRCm39)	F81L	probably benign	Het
Vmn2r15	A	T	5: 109,440,970 (GRCm39)	V296E	probably benign	Het
Vmn2r15	C	T	5: 109,441,310 (GRCm39)	D183N	probably damaging	Het
Zfp763	T	C	17: 33,252,294 (GRCm39)		probably benign	Het

Other mutations in Or1p1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6823:Or1p1b	UTSW	11	74,130,522 (GRCm39)	missense	probably damaging	1.00
R7175:Or1p1b	UTSW	11	74,130,803 (GRCm39)	missense	probably benign
R7195:Or1p1b	UTSW	11	74,130,394 (GRCm39)	start codon destroyed	probably null	0.99
R7808:Or1p1b	UTSW	11	74,130,725 (GRCm39)	missense	probably damaging	1.00
R7934:Or1p1b	UTSW	11	74,131,326 (GRCm39)	missense	probably benign	0.00
R8164:Or1p1b	UTSW	11	74,130,786 (GRCm39)	missense	probably damaging	1.00
R8466:Or1p1b	UTSW	11	74,131,016 (GRCm39)	missense	probably benign	0.00
R8876:Or1p1b	UTSW	11	74,130,846 (GRCm39)	missense	probably damaging	1.00
R8995:Or1p1b	UTSW	11	74,130,620 (GRCm39)	missense	probably benign	0.45
R9504:Or1p1b	UTSW	11	74,131,094 (GRCm39)	missense	probably benign
R9519:Or1p1b	UTSW	11	74,130,827 (GRCm39)	missense	probably benign	0.00
Z1176:Or1p1b	UTSW	11	74,131,029 (GRCm39)	missense	probably damaging	0.99
Z1176:Or1p1b	UTSW	11	74,130,946 (GRCm39)	missense	possibly damaging	0.68
Z1176:Or1p1b	UTSW	11	74,130,573 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCCAACCTGTCCTGTGATG -3'
(R):5'- AAGATGACTGCACCTCCCAG -3'

Sequencing Primer
(F):5'- GCCAACCTGTCCTGTGATGATATC -3'
(R):5'- TGCACCTCCCAGGAAGAG -3'

Posted On

2020-07-28