Mutagenetix > Incidental Mutation

Incidental Mutation 'R8277:Zfp763'

638041

Institutional Source

Beutler Lab

Gene Symbol

Zfp763

Ensembl Gene

ENSMUSG00000067430

Gene Name

zinc finger protein 763

Synonyms

1700065O13Rik

MMRRC Submission

067700-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8277 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

33235838-33252355 bp(-) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

T to C at 33252294 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000084936 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087654]

AlphaFold

Q8BIC7

Predicted Effect

probably benign
Transcript: ENSMUST00000087654

SMART Domains

Protein: ENSMUSP00000084936
Gene: ENSMUSG00000067430

Domain	Start	End	E-Value	Type
KRAB	10	60	7.47e-14	SMART
ZnF_C2H2	223	245	2.53e-2	SMART
ZnF_C2H2	251	273	4.54e-4	SMART
ZnF_C2H2	279	301	1.69e-3	SMART
ZnF_C2H2	307	329	5.72e-1	SMART
ZnF_C2H2	335	357	1.64e-1	SMART
ZnF_C2H2	363	385	1.56e-2	SMART
ZnF_C2H2	391	413	1.82e-3	SMART
ZnF_C2H2	419	441	1.64e-1	SMART
ZnF_C2H2	447	469	5.9e-3	SMART
ZnF_C2H2	475	497	2.02e-1	SMART
ZnF_C2H2	503	525	7.15e-2	SMART
ZnF_C2H2	531	553	1.79e-2	SMART
ZnF_C2H2	559	581	5.14e-3	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	A	19: 57,204,351 (GRCm39)	L13F	probably benign	Het
Apoe	C	T	7: 19,432,303 (GRCm39)		probably benign	Het
Arap2	A	G	5: 62,771,335 (GRCm39)		probably null	Het
Aspm	T	C	1: 139,382,748 (GRCm39)	S27P	probably damaging	Het
Atcay	C	A	10: 81,050,646 (GRCm39)	D90Y	probably damaging	Het
Cd46	A	T	1: 194,747,030 (GRCm39)	D327E	probably damaging	Het
Cfh	A	G	1: 140,029,347 (GRCm39)	W1001R	probably damaging	Het
Chrm2	G	A	6: 36,500,211 (GRCm39)	V23M	probably benign	Het
Col1a2	G	A	6: 4,516,410 (GRCm39)	G175R	probably null	Het
Ddx52	T	C	11: 83,845,940 (GRCm39)	S422P	probably damaging	Het
Dync2i2	A	G	2: 29,923,886 (GRCm39)	V213A	probably benign	Het
Entr1	G	A	2: 26,274,778 (GRCm39)	A373V	probably damaging	Het
Gucy2d	T	A	7: 98,092,682 (GRCm39)	W20R	probably benign	Het
Hao2	A	G	3: 98,787,700 (GRCm39)	I243T	probably damaging	Het
Hmcn2	A	C	2: 31,259,189 (GRCm39)	T1010P	probably benign	Het
Iqcf1	T	C	9: 106,379,077 (GRCm39)	S29P	probably benign	Het
Kat2b	T	A	17: 53,948,281 (GRCm39)	D350E	probably benign	Het
Lingo4	A	G	3: 94,309,931 (GRCm39)	S290G	possibly damaging	Het
Mmrn1	A	G	6: 60,954,220 (GRCm39)	T834A	probably benign	Het
Mro	A	T	18: 73,997,132 (GRCm39)		probably benign	Het
Mrps26	T	A	2: 130,406,347 (GRCm39)	L160Q	probably damaging	Het
Myh8	T	C	11: 67,183,735 (GRCm39)	I788T	probably benign	Het
Nab2	G	A	10: 127,501,168 (GRCm39)		probably benign	Het
Nr2c2ap	C	T	8: 70,585,131 (GRCm39)	Q67*	probably null	Het
Or1p1b	C	T	11: 74,130,842 (GRCm39)	L151F	probably benign	Het
Pask	C	T	1: 93,253,085 (GRCm39)		probably null	Het
Pcnx2	A	T	8: 126,592,755 (GRCm39)	S736R	probably damaging	Het
Per2	G	T	1: 91,348,274 (GRCm39)	D1109E	probably benign	Het
Plxna1	G	A	6: 89,334,162 (GRCm39)	H156Y	probably damaging	Het
Polr2a	G	A	11: 69,638,882 (GRCm39)	R51C	probably damaging	Het
Rbpms2	T	A	9: 65,556,695 (GRCm39)	F45Y	probably damaging	Het
Rmdn3	T	C	2: 118,976,905 (GRCm39)	D276G	probably damaging	Het
Septin2	T	A	1: 93,427,030 (GRCm39)	I171K	probably benign	Het
Serpinb3a	C	A	1: 106,973,970 (GRCm39)	G314C	probably damaging	Het
Slc35f3	T	A	8: 127,115,925 (GRCm39)	V284D	possibly damaging	Het
Snapc4	A	G	2: 26,255,722 (GRCm39)	V934A	probably benign	Het
Tctn1	A	G	5: 122,402,431 (GRCm39)	M1T	probably null	Het
Tgoln1	G	A	6: 72,593,838 (GRCm39)		probably benign	Het
Unc5c	G	A	3: 141,474,373 (GRCm39)		probably null	Het
Vmn2r11	A	T	5: 109,202,833 (GRCm39)	F81L	probably benign	Het
Vmn2r15	A	T	5: 109,440,970 (GRCm39)	V296E	probably benign	Het
Vmn2r15	C	T	5: 109,441,310 (GRCm39)	D183N	probably damaging	Het

Other mutations in Zfp763

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02638:Zfp763	APN	17	33,238,908 (GRCm39)	missense	probably benign	0.41
IGL03291:Zfp763	APN	17	33,238,860 (GRCm39)	missense	probably damaging	0.96
R0346:Zfp763	UTSW	17	33,238,721 (GRCm39)	missense	probably benign	0.26
R0675:Zfp763	UTSW	17	33,238,774 (GRCm39)	missense	possibly damaging	0.92
R0683:Zfp763	UTSW	17	33,237,892 (GRCm39)	missense	probably damaging	1.00
R1494:Zfp763	UTSW	17	33,240,477 (GRCm39)	missense	probably damaging	0.99
R1521:Zfp763	UTSW	17	33,252,276 (GRCm39)	start codon destroyed	probably benign	0.03
R1607:Zfp763	UTSW	17	33,238,881 (GRCm39)	missense	probably benign	0.08
R1627:Zfp763	UTSW	17	33,240,758 (GRCm39)	missense	probably damaging	1.00
R1714:Zfp763	UTSW	17	33,238,591 (GRCm39)	missense	probably damaging	0.99
R1993:Zfp763	UTSW	17	33,237,413 (GRCm39)	missense	probably damaging	1.00
R2109:Zfp763	UTSW	17	33,238,752 (GRCm39)	missense	probably benign
R4420:Zfp763	UTSW	17	33,237,455 (GRCm39)	missense	probably benign	0.43
R4612:Zfp763	UTSW	17	33,237,922 (GRCm39)	missense	probably benign	0.05
R5114:Zfp763	UTSW	17	33,237,949 (GRCm39)	missense	probably damaging	0.99
R5426:Zfp763	UTSW	17	33,238,569 (GRCm39)	missense	probably benign
R5503:Zfp763	UTSW	17	33,238,507 (GRCm39)	missense	possibly damaging	0.95
R5534:Zfp763	UTSW	17	33,240,768 (GRCm39)	missense	probably damaging	0.97
R6133:Zfp763	UTSW	17	33,237,675 (GRCm39)	missense	possibly damaging	0.75
R7141:Zfp763	UTSW	17	33,237,769 (GRCm39)	missense	probably damaging	0.97
R7365:Zfp763	UTSW	17	33,252,352 (GRCm39)	start gained	probably benign
R7430:Zfp763	UTSW	17	33,238,506 (GRCm39)	missense	possibly damaging	0.68
R7552:Zfp763	UTSW	17	33,237,625 (GRCm39)	missense	probably benign
R8446:Zfp763	UTSW	17	33,238,473 (GRCm39)	missense	probably benign	0.28
R8964:Zfp763	UTSW	17	33,240,710 (GRCm39)	missense	probably benign	0.25
R9662:Zfp763	UTSW	17	33,240,787 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCGCACAATTCCAGTGTC -3'
(R):5'- ATTCTAACTGCACTGGGAAAGAG -3'

Sequencing Primer
(F):5'- AATTCCAGTGTCCCGCTCCAAG -3'
(R):5'- TTAAGGCATTTAAGCTCAAGGC -3'

Posted On

2020-07-28