|Institutional Source||Beutler Lab|
|Gene Name||wingless-type MMTV integration site family, member 7B|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R8278 (G1)|
|Chromosomal Location||85535437-85582473 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to G at 85543686 bp|
|Amino Acid Change||Asparagine to Histidine at position 189 (N189H)|
|Ref Sequence||ENSEMBL: ENSMUSP00000105051 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000023015] [ENSMUST00000109424] [ENSMUST00000167968]|
AA Change: N185H
AA Change: N189H
|Predicted Effect||probably benign
AA Change: N118H
PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
AA Change: N118H
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
PHENOTYPE: Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wnt7b||
(F):5'- AACTTGAGGTGTCAGGCCTG -3'
(R):5'- CTGAGCAATTGTGGCTGTGAC -3'
(F):5'- TGTCAGGCCTGCACAAAG -3'
(R):5'- GCTGTGACCGGGAGAAGC -3'