Incidental Mutation 'R8281:Rasl2-9'
ID 638196
Institutional Source Beutler Lab
Gene Symbol Rasl2-9
Ensembl Gene ENSMUSG00000083649
Gene Name RAS-like, family 2, locus 9
Synonyms Rasl2-9-ps, Ran/M2
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.863) question?
Stock # R8281 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 5124938-5125950 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 5125352 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 193 (L193*)
Ref Sequence ENSEMBL: ENSMUSP00000129559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000147835]
AlphaFold Q61820
Predicted Effect probably null
Transcript: ENSMUST00000147835
AA Change: L193*
SMART Domains Protein: ENSMUSP00000129559
Gene: ENSMUSG00000083649
AA Change: L193*

DomainStartEndE-ValueType
RAN 16 216 1.25e-161 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 98% (44/45)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931409K22Rik T A 5: 24,549,010 H417L probably benign Het
Adam7 G A 14: 68,507,885 T630I possibly damaging Het
Adgrf3 T C 5: 30,197,303 S576G possibly damaging Het
Asxl1 A G 2: 153,399,401 R625G probably damaging Het
Atp1a1 A G 3: 101,579,624 F916L probably benign Het
Axl C T 7: 25,763,954 D633N probably benign Het
B230359F08Rik A G 14: 53,795,461 R3G possibly damaging Het
Chd9 A G 8: 91,036,597 D2350G probably damaging Het
Cic G A 7: 25,271,824 V327I probably benign Het
Crym T A 7: 120,202,027 probably benign Het
Cyp3a13 G C 5: 137,894,297 S495C probably benign Het
D5Ertd579e A T 5: 36,613,320 F137I Het
Dip2a T C 10: 76,276,604 T1087A probably damaging Het
Drc7 G A 8: 95,062,177 E288K possibly damaging Het
Epb41l4a T C 18: 33,878,945 E174G probably damaging Het
Ern2 T C 7: 122,170,260 R848G probably damaging Het
F13b G T 1: 139,510,951 R364S probably benign Het
F2rl1 A G 13: 95,514,077 L99P probably damaging Het
Fam193a C A 5: 34,443,436 N171K unknown Het
Fst A G 13: 114,455,241 S201P probably benign Het
Gm10110 C T 14: 89,898,241 V76M noncoding transcript Het
Gm597 C T 1: 28,778,144 C269Y possibly damaging Het
Gm6460 T A 5: 11,597,679 M128K probably damaging Het
Gm8232 A G 14: 44,437,091 I182V Het
Gm8251 T G 1: 44,056,538 D1800A possibly damaging Het
Kalrn C T 16: 34,035,061 W1956* probably null Het
Klk1b16 A G 7: 44,141,547 M258V probably benign Het
Lta4h G T 10: 93,453,594 D29Y probably damaging Het
March7 C T 2: 60,234,529 S383L probably benign Het
Mob3c T C 4: 115,831,438 I56T probably benign Het
Msl2 T C 9: 101,101,695 S423P probably benign Het
Otop3 T C 11: 115,345,075 I511T possibly damaging Het
Pbld2 T G 10: 63,048,026 L90R probably damaging Het
Pcdh8 A G 14: 79,769,479 V548A probably damaging Het
Peg10 CATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAGGATC CATC 6: 4,756,431 probably benign Het
Plch2 T A 4: 155,006,973 M228L probably benign Het
Prkdc T C 16: 15,705,253 C1180R probably damaging Het
Rbp3 A G 14: 33,956,363 K756R probably benign Het
Rp1 T C 1: 4,347,916 E991G probably damaging Het
Slc12a7 G A 13: 73,790,677 R191H probably damaging Het
Spaca6 A G 17: 17,832,059 N87S possibly damaging Het
Stab2 A T 10: 86,873,864 V1639E probably damaging Het
Thpo T C 16: 20,725,775 N235S possibly damaging Het
Tmem63b T A 17: 45,660,796 H831L probably benign Het
Tomm20l T C 12: 71,111,467 V8A probably benign Het
Vill T C 9: 119,058,479 S104P probably damaging Het
Other mutations in Rasl2-9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Rasl2-9 APN 7 5125347 missense probably benign 0.00
R1500:Rasl2-9 UTSW 7 5125442 nonsense probably null
R4566:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4567:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4568:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4745:Rasl2-9 UTSW 7 5125703 missense possibly damaging 0.90
R7301:Rasl2-9 UTSW 7 5125740 missense probably damaging 1.00
R8025:Rasl2-9 UTSW 7 5125482 missense probably damaging 1.00
R9272:Rasl2-9 UTSW 7 5125449 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCACATTCACTCCGAAGC -3'
(R):5'- ATTCTCTTCCACCGAAAGAAGAATC -3'

Sequencing Primer
(F):5'- TTCAGCATCCCAATGAATTGC -3'
(R):5'- CTTCAGTACTATGACATTTCTGCCAG -3'
Posted On 2020-07-28