Incidental Mutation 'R8282:Or8b54'
ID 638265
Institutional Source Beutler Lab
Gene Symbol Or8b54
Ensembl Gene ENSMUSG00000049926
Gene Name olfactory receptor family 8 subfamily B member 54
Synonyms MOR165-8, GA_x6K02T2PVTD-32478047-32478988, Olfr921
MMRRC Submission 067705-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R8282 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38684384-38687650 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38686577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 9 (V9M)
Gene Model predicted gene model for transcript(s):
AlphaFold Q7TRC0
Predicted Effect noncoding transcript
Transcript: ENSMUST00000062124
AA Change: V9M
SMART Domains Protein: ENSMUSP00000051879
Gene: ENSMUSG00000049926
AA Change: V9M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-48 PFAM
Pfam:7tm_1 41 290 6.3e-23 PFAM
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy10 T A 1: 165,337,906 (GRCm39) D173E probably benign Het
Ahctf1 T C 1: 179,605,371 (GRCm39) D721G possibly damaging Het
Allc T C 12: 28,607,356 (GRCm39) T299A probably damaging Het
Ankrd55 T A 13: 112,459,575 (GRCm39) probably benign Het
Axl C T 7: 25,463,379 (GRCm39) D633N probably benign Het
Brf2 G T 8: 27,614,621 (GRCm39) R30S Het
Bsn A G 9: 107,984,890 (GRCm39) S283P possibly damaging Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Ces1d A T 8: 93,912,740 (GRCm39) S233T possibly damaging Het
Chst15 T A 7: 131,871,879 (GRCm39) H134L probably benign Het
Col14a1 A G 15: 55,284,276 (GRCm39) T846A unknown Het
Cwh43 A T 5: 73,591,572 (GRCm39) D555V probably damaging Het
Cyld C A 8: 89,432,043 (GRCm39) P14T probably benign Het
Dctn1 G A 6: 83,176,738 (GRCm39) R1264H possibly damaging Het
Dkk3 T A 7: 111,717,489 (GRCm39) S327C probably damaging Het
Dnmbp T G 19: 43,879,005 (GRCm39) H22P unknown Het
Duxf4 T G 10: 58,072,148 (GRCm39) Q22P possibly damaging Het
Fabp4 T A 3: 10,270,342 (GRCm39) T103S probably benign Het
Fam43a T C 16: 30,420,106 (GRCm39) L230P probably damaging Het
Fam83h ACTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGT ACTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGT 15: 75,874,624 (GRCm39) probably benign Het
Fank1 T A 7: 133,478,493 (GRCm39) Y186N probably damaging Het
Fbxo8 G A 8: 57,044,555 (GRCm39) R286K possibly damaging Het
Fmnl2 G A 2: 52,997,678 (GRCm39) probably null Het
Gli2 T A 1: 118,765,701 (GRCm39) S817C probably damaging Het
Gm10110 C T 14: 90,135,677 (GRCm39) V76M noncoding transcript Het
Gstt2 C G 10: 75,668,291 (GRCm39) A155P probably benign Het
Ints9 T A 14: 65,244,757 (GRCm39) M213K probably benign Het
Jak1 G A 4: 101,036,738 (GRCm39) R301* probably null Het
Kdsr T C 1: 106,652,727 (GRCm39) T302A probably benign Het
Khsrp T C 17: 57,331,123 (GRCm39) E460G probably damaging Het
Larp1b G A 3: 40,991,245 (GRCm39) R193H probably damaging Het
Nedd4l A G 18: 65,324,560 (GRCm39) K487R probably damaging Het
Niban2 A G 2: 32,809,029 (GRCm39) E205G probably benign Het
Nwd1 T A 8: 73,431,580 (GRCm39) S1193T probably damaging Het
Or10ag57 A T 2: 87,218,852 (GRCm39) T268S probably benign Het
Or5k3 T A 16: 58,969,529 (GRCm39) C105* probably null Het
Padi1 T C 4: 140,542,014 (GRCm39) H636R probably damaging Het
Pdilt A G 7: 119,097,293 (GRCm39) I266T probably damaging Het
Rell2 A T 18: 38,090,665 (GRCm39) Q114L probably benign Het
Rfc1 A G 5: 65,426,289 (GRCm39) probably null Het
Rpia T C 6: 70,748,002 (GRCm39) N265D possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGCGGCGG 7: 97,229,127 (GRCm39) probably null Het
Samd12 T C 15: 53,723,645 (GRCm39) D16G probably damaging Het
Slc25a54 T C 3: 109,006,005 (GRCm39) probably null Het
Slc6a3 T A 13: 73,705,200 (GRCm39) D230E probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Synpo2l A G 14: 20,711,204 (GRCm39) V472A probably benign Het
Taf6l A G 19: 8,750,714 (GRCm39) I120T possibly damaging Het
Tent5c A G 3: 100,380,327 (GRCm39) V143A probably damaging Het
Trappc11 T C 8: 47,969,624 (GRCm39) D328G probably damaging Het
Trp53bp1 A G 2: 121,029,523 (GRCm39) S1836P probably damaging Het
Ugt2b37 G A 5: 87,402,440 (GRCm39) L64F probably benign Het
Vmn2r56 A T 7: 12,449,601 (GRCm39) Y212* probably null Het
Vps54 T A 11: 21,250,464 (GRCm39) probably benign Het
Zfp268 A T 4: 145,349,547 (GRCm39) D328V possibly damaging Het
Zfp648 T A 1: 154,080,535 (GRCm39) H231Q probably benign Het
Zscan4d T A 7: 10,896,369 (GRCm39) T334S possibly damaging Het
Zswim9 T C 7: 12,995,536 (GRCm39) M207V probably benign Het
Other mutations in Or8b54
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or8b54 APN 9 38,687,108 (GRCm39) nonsense probably null
IGL01016:Or8b54 APN 9 38,686,737 (GRCm39) missense probably damaging 0.99
IGL01391:Or8b54 APN 9 38,686,826 (GRCm39) missense probably damaging 1.00
IGL01451:Or8b54 APN 9 38,687,225 (GRCm39) missense probably benign 0.04
IGL02250:Or8b54 APN 9 38,686,850 (GRCm39) missense probably damaging 1.00
R0026:Or8b54 UTSW 9 38,686,892 (GRCm39) missense probably benign 0.01
R0334:Or8b54 UTSW 9 38,686,535 (GRCm39) critical splice acceptor site probably null
R0655:Or8b54 UTSW 9 38,686,850 (GRCm39) nonsense probably null
R1024:Or8b54 UTSW 9 38,686,631 (GRCm39) missense probably damaging 0.97
R3522:Or8b54 UTSW 9 38,687,016 (GRCm39) missense possibly damaging 0.67
R3967:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R3968:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R3969:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R4761:Or8b54 UTSW 9 38,687,133 (GRCm39) missense probably benign 0.05
R4796:Or8b54 UTSW 9 38,686,670 (GRCm39) missense probably benign 0.15
R4880:Or8b54 UTSW 9 38,686,843 (GRCm39) nonsense probably null
R5237:Or8b54 UTSW 9 38,687,252 (GRCm39) missense probably damaging 1.00
R5756:Or8b54 UTSW 9 38,686,554 (GRCm39) start codon destroyed probably null 1.00
R6230:Or8b54 UTSW 9 38,687,073 (GRCm39) missense possibly damaging 0.94
R6487:Or8b54 UTSW 9 38,686,731 (GRCm39) missense probably damaging 1.00
R7514:Or8b54 UTSW 9 38,686,974 (GRCm39) missense probably damaging 1.00
R7573:Or8b54 UTSW 9 38,686,791 (GRCm39) missense probably damaging 1.00
R7755:Or8b54 UTSW 9 38,687,073 (GRCm39) missense possibly damaging 0.94
R8195:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8196:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8197:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8199:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8211:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8212:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8236:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8239:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8279:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8283:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R9207:Or8b54 UTSW 9 38,686,960 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ACAAGCTATTCGGAAATTTCATCC -3'
(R):5'- TCATAGGCCATTGACACCAG -3'

Sequencing Primer
(F):5'- GCTATTCGGAAATTTCATCCTGAGC -3'
(R):5'- AAGTAGAGTTGGGACATACATCC -3'
Posted On 2020-07-28