Incidental Mutation 'R8284:Or2y1b'
ID 638388
Institutional Source Beutler Lab
Gene Symbol Or2y1b
Ensembl Gene ENSMUSG00000100923
Gene Name olfactory receptor family 2 subfamily Y member 1B
Synonyms L45, MOR256-55, Olfr10, GA_x6K02T2QP88-6117098-6116163
MMRRC Submission 067707-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R8284 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 49208375-49209310 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49209002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 210 (T210A)
Ref Sequence ENSEMBL: ENSMUSP00000139744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570]
AlphaFold Q60883
Predicted Effect probably benign
Transcript: ENSMUST00000187570
AA Change: T210A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: T210A

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T C 10: 61,034,438 (GRCm39) Y1147C possibly damaging Het
Adgrf5 T A 17: 43,766,161 (GRCm39) S1328T unknown Het
Aff4 A G 11: 53,295,379 (GRCm39) K860E probably damaging Het
Aox1 A C 1: 58,115,250 (GRCm39) H745P probably damaging Het
Bpifc T C 10: 85,836,413 (GRCm39) T31A probably benign Het
C3 C A 17: 57,530,938 (GRCm39) V388L probably benign Het
Celsr3 G T 9: 108,723,612 (GRCm39) M2874I probably damaging Het
Cnga4 T A 7: 105,057,239 (GRCm39) D550E probably benign Het
Dhx8 A G 11: 101,648,455 (GRCm39) T918A probably damaging Het
Dnah14 A C 1: 181,601,376 (GRCm39) E3670A probably benign Het
Fbxo31 T C 8: 122,287,181 (GRCm39) I131V probably benign Het
Ftcd T C 10: 76,413,893 (GRCm39) V99A probably benign Het
Gucy2e A G 11: 69,123,177 (GRCm39) V471A probably benign Het
H60b T A 10: 22,162,971 (GRCm39) L182Q probably benign Het
Hbp1 G A 12: 31,987,625 (GRCm39) H188Y probably damaging Het
Itga4 C T 2: 79,151,783 (GRCm39) T862I probably benign Het
Kcnmb4 T A 10: 116,254,158 (GRCm39) K206N probably damaging Het
Klra4 A G 6: 130,042,243 (GRCm39) F8S possibly damaging Het
Mrpl2 C A 17: 46,958,435 (GRCm39) Y72* probably null Het
Nars2 C A 7: 96,600,845 (GRCm39) probably benign Het
Nup214 T C 2: 31,886,458 (GRCm39) S607P possibly damaging Het
Oas1d C T 5: 121,057,221 (GRCm39) R276* probably null Het
Or12d13 C T 17: 37,647,587 (GRCm39) V179I probably benign Het
Or1l8 T A 2: 36,818,018 (GRCm39) Y36F probably damaging Het
Or2t1 T A 14: 14,329,011 (GRCm38) L300Q possibly damaging Het
Pex13 A G 11: 23,605,685 (GRCm39) S182P possibly damaging Het
Piwil4 G T 9: 14,638,774 (GRCm39) N297K probably benign Het
Plxna4 T C 6: 32,129,789 (GRCm39) T1845A probably benign Het
Pml T C 9: 58,136,643 (GRCm39) N579D probably benign Het
Ppl A G 16: 4,950,201 (GRCm39) S3P probably damaging Het
Pramel16 G T 4: 143,676,695 (GRCm39) D136E possibly damaging Het
Prss54 G A 8: 96,285,994 (GRCm39) Q360* probably null Het
Ralgps2 A G 1: 156,655,718 (GRCm39) I402T probably benign Het
Rnf213 T A 11: 119,318,909 (GRCm39) D1123E Het
Sdha A T 13: 74,479,416 (GRCm39) probably null Het
Senp8 G A 9: 59,644,814 (GRCm39) T114I Het
Setx C T 2: 29,035,348 (GRCm39) T611I possibly damaging Het
Shc1 T G 3: 89,329,215 (GRCm39) S20A possibly damaging Het
Slc15a1 T C 14: 121,727,275 (GRCm39) I98V probably benign Het
Snrk A G 9: 121,989,538 (GRCm39) E294G probably damaging Het
Sox18 G A 2: 181,312,751 (GRCm39) P127S probably damaging Het
Spta1 A G 1: 174,007,387 (GRCm39) T206A probably benign Het
Tcfl5 A G 2: 180,280,330 (GRCm39) S358P probably benign Het
Tecta T A 9: 42,289,325 (GRCm39) L413F possibly damaging Het
Tlk1 T C 2: 70,544,365 (GRCm39) T757A probably benign Het
Tmem232 T A 17: 65,709,990 (GRCm39) I433F probably damaging Het
Top1mt T A 15: 75,539,712 (GRCm39) K300* probably null Het
Trbv20 C T 6: 41,165,782 (GRCm39) A69V probably damaging Het
Trim12a A T 7: 103,955,282 (GRCm39) L147Q probably damaging Het
Tuba8 G A 6: 121,199,736 (GRCm39) S140N probably damaging Het
Vcan A T 13: 89,852,454 (GRCm39) N835K possibly damaging Het
Xrcc1 G A 7: 24,271,703 (GRCm39) R562H probably damaging Het
Yipf7 C T 5: 69,674,539 (GRCm39) G202D probably benign Het
Ythdc1 T G 5: 86,964,325 (GRCm39) S45A probably benign Het
Zfp1002 T C 2: 150,097,276 (GRCm39) probably benign Het
Other mutations in Or2y1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Or2y1b APN 11 49,209,127 (GRCm39) nonsense probably null 0.00
IGL02283:Or2y1b APN 11 49,209,162 (GRCm39) missense probably benign
IGL03010:Or2y1b APN 11 49,208,973 (GRCm39) missense probably damaging 0.99
R0575:Or2y1b UTSW 11 49,208,880 (GRCm39) missense probably damaging 1.00
R1430:Or2y1b UTSW 11 49,208,928 (GRCm39) splice site probably null
R1891:Or2y1b UTSW 11 49,208,684 (GRCm39) missense probably benign 0.00
R2509:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R2511:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R4942:Or2y1b UTSW 11 49,208,375 (GRCm39) start codon destroyed probably null 0.99
R5080:Or2y1b UTSW 11 49,208,914 (GRCm39) missense probably benign 0.03
R5413:Or2y1b UTSW 11 49,209,240 (GRCm39) missense probably damaging 1.00
R5843:Or2y1b UTSW 11 49,209,076 (GRCm39) missense probably benign 0.34
R6354:Or2y1b UTSW 11 49,208,465 (GRCm39) missense probably damaging 0.98
R6605:Or2y1b UTSW 11 49,208,541 (GRCm39) missense probably damaging 0.97
R8005:Or2y1b UTSW 11 49,208,968 (GRCm39) missense probably benign 0.12
R8902:Or2y1b UTSW 11 49,209,206 (GRCm39) missense probably benign 0.03
R9003:Or2y1b UTSW 11 49,209,155 (GRCm39) missense possibly damaging 0.66
R9431:Or2y1b UTSW 11 49,208,459 (GRCm39) missense probably benign
R9696:Or2y1b UTSW 11 49,208,390 (GRCm39) missense probably benign
Predicted Primers
Posted On 2020-07-28