Incidental Mutation 'R8284:Olfr10'
ID638388
Institutional Source Beutler Lab
Gene Symbol Olfr10
Ensembl Gene ENSMUSG00000100923
Gene Nameolfactory receptor 10
SynonymsMOR256-55, L45, GA_x6K02T2QP88-6117098-6116163
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #R8284 (G1)
Quality Score225.009
Status Not validated
Chromosome11
Chromosomal Location49304741-49320021 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 49318175 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 210 (T210A)
Ref Sequence ENSEMBL: ENSMUSP00000139744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570]
Predicted Effect probably benign
Transcript: ENSMUST00000187570
AA Change: T210A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: T210A

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T C 10: 61,198,659 Y1147C possibly damaging Het
Adgrf5 T A 17: 43,455,270 S1328T unknown Het
Aff4 A G 11: 53,404,552 K860E probably damaging Het
Aox1 A C 1: 58,076,091 H745P probably damaging Het
Bpifc T C 10: 86,000,549 T31A probably benign Het
C3 C A 17: 57,223,938 V388L probably benign Het
Celsr3 G T 9: 108,846,413 M2874I probably damaging Het
Cnga4 T A 7: 105,408,032 D550E probably benign Het
Dhx8 A G 11: 101,757,629 T918A probably damaging Het
Dnah14 A C 1: 181,773,811 E3670A probably benign Het
Fbxo31 T C 8: 121,560,442 I131V probably benign Het
Ftcd T C 10: 76,578,059 V99A probably benign Het
Gucy2e A G 11: 69,232,351 V471A probably benign Het
H60b T A 10: 22,287,072 L182Q probably benign Het
Hbp1 G A 12: 31,937,626 H188Y probably damaging Het
Itga4 C T 2: 79,321,439 T862I probably benign Het
Kcnmb4 T A 10: 116,418,253 K206N probably damaging Het
Klra4 A G 6: 130,065,280 F8S possibly damaging Het
Mrpl2 C A 17: 46,647,509 Y72* probably null Het
Nup214 T C 2: 31,996,446 S607P possibly damaging Het
Oas1d C T 5: 120,919,158 R276* probably null Het
Olfr103 C T 17: 37,336,696 V179I probably benign Het
Olfr31 T A 14: 14,329,011 L300Q possibly damaging Het
Olfr355 T A 2: 36,928,006 Y36F probably damaging Het
Pex13 A G 11: 23,655,685 S182P possibly damaging Het
Piwil4 G T 9: 14,727,478 N297K probably benign Het
Plxna4 T C 6: 32,152,854 T1845A probably benign Het
Pml T C 9: 58,229,360 N579D probably benign Het
Ppl A G 16: 5,132,337 S3P probably damaging Het
Pramef25 G T 4: 143,950,125 D136E possibly damaging Het
Prss54 G A 8: 95,559,366 Q360* probably null Het
Ralgps2 A G 1: 156,828,148 I402T probably benign Het
Rnf213 T A 11: 119,428,083 D1123E Het
Sdha A T 13: 74,331,297 probably null Het
Senp8 G A 9: 59,737,531 T114I Het
Setx C T 2: 29,145,336 T611I possibly damaging Het
Shc1 T G 3: 89,421,908 S20A possibly damaging Het
Slc15a1 T C 14: 121,489,863 I98V probably benign Het
Snrk A G 9: 122,160,472 E294G probably damaging Het
Sox18 G A 2: 181,670,958 P127S probably damaging Het
Spta1 A G 1: 174,179,821 T206A probably benign Het
Tcfl5 A G 2: 180,638,537 S358P probably benign Het
Tecta T A 9: 42,378,029 L413F possibly damaging Het
Tlk1 T C 2: 70,714,021 T757A probably benign Het
Tmem232 T A 17: 65,402,995 I433F probably damaging Het
Top1mt T A 15: 75,667,863 K300* probably null Het
Trbv20 C T 6: 41,188,848 A69V probably damaging Het
Trim12a A T 7: 104,306,075 L147Q probably damaging Het
Tuba8 G A 6: 121,222,777 S140N probably damaging Het
Vcan A T 13: 89,704,335 N835K possibly damaging Het
Xrcc1 G A 7: 24,572,278 R562H probably damaging Het
Yipf7 C T 5: 69,517,196 G202D probably benign Het
Ythdc1 T G 5: 86,816,466 S45A probably benign Het
Other mutations in Olfr10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Olfr10 APN 11 49318300 nonsense probably null 0.00
IGL02283:Olfr10 APN 11 49318335 missense probably benign
IGL03010:Olfr10 APN 11 49318146 missense probably damaging 0.99
R0575:Olfr10 UTSW 11 49318053 missense probably damaging 1.00
R1430:Olfr10 UTSW 11 49318101 splice site probably null
R1891:Olfr10 UTSW 11 49317857 missense probably benign 0.00
R2509:Olfr10 UTSW 11 49318221 missense probably damaging 0.97
R2511:Olfr10 UTSW 11 49318221 missense probably damaging 0.97
R4942:Olfr10 UTSW 11 49317548 start codon destroyed probably null 0.99
R5080:Olfr10 UTSW 11 49318087 missense probably benign 0.03
R5413:Olfr10 UTSW 11 49318413 missense probably damaging 1.00
R5843:Olfr10 UTSW 11 49318249 missense probably benign 0.34
R6354:Olfr10 UTSW 11 49317638 missense probably damaging 0.98
R6605:Olfr10 UTSW 11 49317714 missense probably damaging 0.97
R8005:Olfr10 UTSW 11 49318141 missense probably benign 0.12
Predicted Primers
Posted On2020-07-28