Incidental Mutation 'R8285:Olfr1297'
ID 638407
Institutional Source Beutler Lab
Gene Symbol Olfr1297
Ensembl Gene ENSMUSG00000094858
Gene Name olfactory receptor 1297
Synonyms GA_x6K02T2Q125-72673494-72672556, MOR248-4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R8285 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111615233-111626497 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111622045 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 10 (S10T)
Ref Sequence ENSEMBL: ENSMUSP00000097207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099612] [ENSMUST00000207283]
AlphaFold Q8VGE8
Predicted Effect probably benign
Transcript: ENSMUST00000099612
AA Change: S10T

PolyPhen 2 Score 0.318 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097207
Gene: ENSMUSG00000094858
AA Change: S10T

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 4.8e-48 PFAM
Pfam:7tm_1 41 287 6.7e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207283
AA Change: S10T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 A G 10: 89,068,217 I206T probably damaging Het
Atp5j A G 16: 84,828,502 L71P probably damaging Het
Bcar3 A T 3: 122,512,734 I468F probably benign Het
Ddi1 T A 9: 6,265,808 Q187L probably benign Het
Dgkh T C 14: 78,628,126 N139D probably benign Het
Fan1 A T 7: 64,366,600 I592N probably damaging Het
Fchsd2 T C 7: 101,233,921 F252S possibly damaging Het
Gad2 T A 2: 22,624,928 N139K probably benign Het
Gm12695 G A 4: 96,769,753 R60W possibly damaging Het
Gm13023 T A 4: 143,794,066 D293E probably benign Het
Gucy1b2 A G 14: 62,420,107 V224A probably damaging Het
Hspg2 A G 4: 137,512,663 D514G probably benign Het
Igsf23 T C 7: 19,941,956 D113G possibly damaging Het
Inhbc T C 10: 127,370,141 T86A probably benign Het
Itga11 T C 9: 62,752,258 S431P probably damaging Het
Kif13b A G 14: 64,782,376 H1398R probably benign Het
Lce1f T C 3: 92,718,931 S140G unknown Het
Mapt T A 11: 104,298,802 D215E probably benign Het
Maz T C 7: 127,025,472 Y292C possibly damaging Het
Mfsd8 G A 3: 40,835,193 R140C probably damaging Het
Mpo A G 11: 87,797,567 M351V probably benign Het
Muc16 G A 9: 18,642,977 P4007S unknown Het
Olfr1094 T C 2: 86,829,099 F116L probably benign Het
Olfr196 G A 16: 59,167,813 T110I probably benign Het
Ppp3ca A G 3: 136,881,444 D229G probably damaging Het
Rab39 A T 9: 53,705,931 I62N probably damaging Het
Rgs6 A G 12: 83,116,175 E385G probably benign Het
Scaf8 T C 17: 3,177,129 S340P unknown Het
Scpep1 A G 11: 88,952,467 L55P probably damaging Het
Sorbs2 T C 8: 45,796,067 L785P probably damaging Het
Supt16 A T 14: 52,181,083 V239E possibly damaging Het
Usf3 T C 16: 44,220,844 S1896P probably damaging Het
Xrcc1 G A 7: 24,572,278 R562H probably damaging Het
Zfhx4 C T 3: 5,401,856 T2383I probably benign Het
Other mutations in Olfr1297
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01068:Olfr1297 APN 2 111621340 missense probably damaging 1.00
IGL01305:Olfr1297 APN 2 111621201 missense probably damaging 1.00
IGL01903:Olfr1297 APN 2 111621658 missense probably benign 0.01
IGL01984:Olfr1297 APN 2 111621582 missense probably benign 0.34
IGL03065:Olfr1297 APN 2 111621190 missense probably damaging 0.98
ANU22:Olfr1297 UTSW 2 111621201 missense probably damaging 1.00
R0313:Olfr1297 UTSW 2 111621600 missense possibly damaging 0.77
R0615:Olfr1297 UTSW 2 111621919 missense possibly damaging 0.95
R1028:Olfr1297 UTSW 2 111621525 missense probably damaging 1.00
R1078:Olfr1297 UTSW 2 111621345 missense probably damaging 1.00
R1158:Olfr1297 UTSW 2 111621741 missense probably damaging 1.00
R1419:Olfr1297 UTSW 2 111621295 missense probably benign 0.05
R1980:Olfr1297 UTSW 2 111621241 missense probably benign 0.00
R1981:Olfr1297 UTSW 2 111621241 missense probably benign 0.00
R2044:Olfr1297 UTSW 2 111621814 missense probably benign 0.02
R2080:Olfr1297 UTSW 2 111621739 missense probably benign
R2170:Olfr1297 UTSW 2 111621600 missense possibly damaging 0.77
R4494:Olfr1297 UTSW 2 111621148 nonsense probably null
R4965:Olfr1297 UTSW 2 111621534 missense probably damaging 1.00
R5175:Olfr1297 UTSW 2 111621426 missense possibly damaging 0.78
R5891:Olfr1297 UTSW 2 111621433 missense probably damaging 1.00
R6192:Olfr1297 UTSW 2 111621175 missense possibly damaging 0.91
R6383:Olfr1297 UTSW 2 111621186 missense probably benign 0.10
R6730:Olfr1297 UTSW 2 111621735 missense probably damaging 0.96
R7189:Olfr1297 UTSW 2 111621193 missense probably benign 0.03
R7193:Olfr1297 UTSW 2 111621255 missense probably damaging 1.00
R7199:Olfr1297 UTSW 2 111621193 missense probably benign 0.01
R7735:Olfr1297 UTSW 2 111621474 missense probably damaging 1.00
R8017:Olfr1297 UTSW 2 111622067 missense probably benign 0.00
R8019:Olfr1297 UTSW 2 111622067 missense probably benign 0.00
R8419:Olfr1297 UTSW 2 111621504 missense probably benign 0.10
R9258:Olfr1297 UTSW 2 111621984 missense possibly damaging 0.77
X0063:Olfr1297 UTSW 2 111621381 missense probably benign 0.04
Z1176:Olfr1297 UTSW 2 111621261 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTTGGCCAACAAGAAGTAC -3'
(R):5'- ATGGAAAGCTGCTCTTGACTC -3'

Sequencing Primer
(F):5'- TTGGCCAACAAGAAGTACATGGG -3'
(R):5'- ACCTTGTGCAAAAATGTCATCC -3'
Posted On 2020-07-28