|Institutional Source||Beutler Lab|
|Gene Name||phospholipase A2, group IVE|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8288 (G1)|
|Chromosomal Location||120166412-120245335 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||C to T at 120188509 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000087525 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000090071]|
|Predicted Effect||probably null
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pla2g4e||
(F):5'- TTTAAAGGAATGCTGGCATCAG -3'
(R):5'- AACAGCTGTTCCTTCTCCATGG -3'
(F):5'- GGTGGAACCTGGACACTTTAC -3'
(R):5'- CATGGCCCTAGGACCAAGTATG -3'