Mutagenetix > Incidental Mutation

Incidental Mutation 'R8289:Or8b37'

638581

Institutional Source

Beutler Lab

Gene Symbol

Or8b37

Ensembl Gene

ENSMUSG00000095893

Gene Name

olfactory receptor family 8 subfamily B member 37

Synonyms

GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P

MMRRC Submission

067711-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R8289 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

37957851-37961433 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 37959000 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 161 (C161S)

Ref Sequence

ENSEMBL: ENSMUSP00000138035 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077732] [ENSMUST00000181088]

AlphaFold

Q7TRE1

Predicted Effect

probably benign
Transcript: ENSMUST00000077732
AA Change: C161S

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: C161S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	8e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	300	1.5e-6	PFAM
Pfam:7tm_1	41	288	5.1e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000181088
AA Change: C161S

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: C161S

Domain	Start	End	E-Value	Type
low complexity region	14	33	N/A	INTRINSIC
Pfam:7TM_GPCR_Srsx	35	300	1.5e-6	PFAM
Pfam:7tm_1	41	288	4.6e-30	PFAM
Pfam:7tm_4	138	281	3.9e-45	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (62/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	G	C	11: 109,927,515 (GRCm39)		probably benign	Het
Adamts3	C	A	5: 89,923,282 (GRCm39)	D175Y	possibly damaging	Het
Adra1b	G	A	11: 43,726,315 (GRCm39)	P201S	probably damaging	Het
Ahnak2	A	G	12: 112,742,242 (GRCm39)	V610A	possibly damaging	Het
Ap5s1	A	C	2: 131,054,379 (GRCm39)	H62P	probably benign	Het
Apeh	A	G	9: 107,963,444 (GRCm39)	S593P	probably damaging	Het
Arhgap24	T	C	5: 103,028,692 (GRCm39)	V289A	possibly damaging	Het
Atoh1	A	G	6: 64,706,893 (GRCm39)	E196G	probably damaging	Het
Atp1b3	G	A	9: 96,215,602 (GRCm39)	S271L	probably benign	Het
Atp6v0a1	A	G	11: 100,924,931 (GRCm39)	R339G	probably damaging	Het
Calb2	T	C	8: 110,894,690 (GRCm39)	H27R	possibly damaging	Het
Camkk2	A	C	5: 122,894,689 (GRCm39)	L201R	probably damaging	Het
Car15	A	G	16: 17,654,580 (GRCm39)		probably null	Het
Cecr2	A	G	6: 120,735,077 (GRCm39)	N771S	probably benign	Het
Celsr1	G	T	15: 85,917,286 (GRCm39)	S229*	probably null	Het
Csmd1	T	A	8: 16,108,716 (GRCm39)	I1896F	probably damaging	Het
Cubn	C	T	2: 13,491,613 (GRCm39)	V145I	probably benign	Het
Cuedc1	G	A	11: 88,073,381 (GRCm39)	S182N	probably benign	Het
Cux1	T	A	5: 136,337,358 (GRCm39)	E718V	probably damaging	Het
Cyp7a1	G	A	4: 6,268,295 (GRCm39)	P477S	probably damaging	Het
Dcaf17	T	A	2: 70,885,718 (GRCm39)	W16R		Het
Dhx8	T	A	11: 101,631,571 (GRCm39)	M388K	probably benign	Het
Dnah14	T	A	1: 181,543,780 (GRCm39)	Y2453*	probably null	Het
Epha8	G	T	4: 136,665,897 (GRCm39)	L420M	probably damaging	Het
F830016B08Rik	G	A	18: 60,433,360 (GRCm39)	E148K	probably benign	Het
Hectd4	A	G	5: 121,404,424 (GRCm39)	T434A	possibly damaging	Het
Ide	A	G	19: 37,290,952 (GRCm39)	L368P		Het
Ide	G	C	19: 37,290,953 (GRCm39)	L368V	probably null	Het
Ifi206	T	C	1: 173,308,032 (GRCm39)	I655V		Het
Insrr	A	G	3: 87,721,501 (GRCm39)	M1136V	probably damaging	Het
Kcne2	A	G	16: 92,093,707 (GRCm39)	E78G	probably damaging	Het
Lrrc23	A	T	6: 124,755,267 (GRCm39)	L90H	probably damaging	Het
Magel2	A	C	7: 62,028,875 (GRCm39)	Q593P	unknown	Het
Mrgpra3	G	A	7: 47,239,468 (GRCm39)	H153Y	possibly damaging	Het
Msln	A	G	17: 25,967,880 (GRCm39)	V595A	possibly damaging	Het
Mvb12a	T	C	8: 71,995,703 (GRCm39)		probably null	Het
Myo7a	T	G	7: 97,726,376 (GRCm39)	M966L	probably benign	Het
Ncoa5	C	T	2: 164,854,982 (GRCm39)	D47N	possibly damaging	Het
Neurl4	T	A	11: 69,800,206 (GRCm39)		probably null	Het
Or1e29	T	A	11: 73,667,839 (GRCm39)	M105L	probably benign	Het
Or4d1	T	C	11: 87,805,589 (GRCm39)	T48A	probably benign	Het
Or5p75-ps1	T	A	7: 108,108,125 (GRCm39)	H287Q	unknown	Het
Osbpl7	T	A	11: 96,947,405 (GRCm39)	S480T	probably benign	Het
Podnl1	T	C	8: 84,858,552 (GRCm39)	L484P		Het
Polr3gl	G	T	3: 96,489,228 (GRCm39)		probably benign	Het
Prkaa1	G	T	15: 5,206,563 (GRCm39)	V438L	possibly damaging	Het
Prune2	A	T	19: 17,100,373 (GRCm39)	H1959L	probably benign	Het
Rad50	A	T	11: 53,589,685 (GRCm39)	L172*	probably null	Het
Samsn1	C	A	16: 75,685,684 (GRCm39)	G25W	probably damaging	Het
Sbno1	T	G	5: 124,542,068 (GRCm39)	L362F	probably damaging	Het
Slc26a6	G	A	9: 108,733,230 (GRCm39)	R43H	probably benign	Het
Slc35f5	T	G	1: 125,490,252 (GRCm39)	Y49*	probably null	Het
Slc41a2	T	C	10: 83,137,044 (GRCm39)	I288V	probably benign	Het
Slc9c1	A	G	16: 45,403,344 (GRCm39)	M804V	probably benign	Het
Smc6	T	A	12: 11,324,052 (GRCm39)	S66T	probably benign	Het
Ssh1	T	C	5: 114,080,445 (GRCm39)	D995G	probably benign	Het
Stk11	G	T	10: 79,961,740 (GRCm39)		probably benign	Het
Sycp1	A	G	3: 102,748,353 (GRCm39)	I813T	probably benign	Het
Tmem121b	A	T	6: 120,469,722 (GRCm39)	S332T	possibly damaging	Het
Treml4	A	C	17: 48,581,456 (GRCm39)	I244L	probably benign	Het
Unc13b	T	A	4: 43,172,524 (GRCm39)	C1117*	probably null	Het
Wdr35	A	G	12: 9,058,020 (GRCm39)	I526V	probably benign	Het
Zap70	T	C	1: 36,820,218 (GRCm39)	W500R	probably damaging	Het
Zfr	G	T	15: 12,135,357 (GRCm39)	V49F	noncoding transcript	Het

Other mutations in Or8b37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00870:Or8b37	APN	9	37,959,036 (GRCm39)	missense	probably damaging	1.00
IGL02612:Or8b37	APN	9	37,958,662 (GRCm39)	missense	probably damaging	1.00
IGL02802:Or8b37	UTSW	9	37,959,345 (GRCm39)	missense	probably damaging	0.99
R0015:Or8b37	UTSW	9	37,958,963 (GRCm39)	nonsense	probably null
R0142:Or8b37	UTSW	9	37,959,406 (GRCm39)	missense	probably benign	0.37
R0559:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0561:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0715:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0723:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0729:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R1350:Or8b37	UTSW	9	37,959,111 (GRCm39)	missense	probably benign	0.02
R1869:Or8b37	UTSW	9	37,959,498 (GRCm39)	splice site	probably null
R3917:Or8b37	UTSW	9	37,958,841 (GRCm39)	missense	probably damaging	1.00
R4131:Or8b37	UTSW	9	37,959,170 (GRCm39)	nonsense	probably null
R4764:Or8b37	UTSW	9	37,959,436 (GRCm39)	missense	probably benign
R5857:Or8b37	UTSW	9	37,959,049 (GRCm39)	missense	probably benign	0.18
R5976:Or8b37	UTSW	9	37,958,997 (GRCm39)	missense	possibly damaging	0.80
R6329:Or8b37	UTSW	9	37,959,121 (GRCm39)	missense	probably benign	0.02
R7344:Or8b37	UTSW	9	37,959,253 (GRCm39)	missense	probably benign
R8485:Or8b37	UTSW	9	37,959,253 (GRCm39)	missense	probably benign	0.00
R8973:Or8b37	UTSW	9	37,958,839 (GRCm39)	missense	possibly damaging	0.95
R9026:Or8b37	UTSW	9	37,958,885 (GRCm39)	nonsense	probably null
R9378:Or8b37	UTSW	9	37,958,775 (GRCm39)	missense	possibly damaging	0.67
R9395:Or8b37	UTSW	9	37,959,136 (GRCm39)	missense	probably damaging	0.99
R9655:Or8b37	UTSW	9	37,959,387 (GRCm39)	missense	probably benign	0.00
R9731:Or8b37	UTSW	9	37,958,892 (GRCm39)	missense	probably damaging	1.00
RF009:Or8b37	UTSW	9	37,959,043 (GRCm39)	missense	probably damaging	1.00
X0052:Or8b37	UTSW	9	37,958,995 (GRCm39)	missense	possibly damaging	0.53
Z1177:Or8b37	UTSW	9	37,959,111 (GRCm39)	missense	possibly damaging	0.95

Predicted Primers

PCR Primer
(F):5'- TCTCTCATGCTGAGTGCTTGAC -3'
(R):5'- TCTGCAGAATGGATGCTGAGG -3'

Sequencing Primer
(F):5'- CATTTGTAAGCCCCTGCT -3'
(R):5'- CAGAATGGATGCTGAGGATGTTG -3'

Posted On

2020-07-28