Incidental Mutation 'R8293:Cxcl2'
ID 638789
Institutional Source Beutler Lab
Gene Symbol Cxcl2
Ensembl Gene ENSMUSG00000058427
Gene Name C-X-C motif chemokine ligand 2
Synonyms MIP-2a, Mgsa-b, Mip2, CINC-2a, Gro2, GROb, Scyb, Scyb2, MIP-2
MMRRC Submission 067783-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8293 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 91051758-91053797 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 91052088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 65 (T65S)
Ref Sequence ENSEMBL: ENSMUSP00000074885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075433] [ENSMUST00000200681]
AlphaFold P10889
PDB Structure SOLUTION STRUCTURE OF MURINE MACROPHAGE INFLAMMATORY PROTEIN-2, NMR, 20 STRUCTURES [SOLUTION NMR]
crystal Structure analysis of MIP2 [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000075433
AA Change: T65S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000074885
Gene: ENSMUSG00000058427
AA Change: T65S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
SCY 33 93 2.07e-20 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000200681
AA Change: T65S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144334
Gene: ENSMUSG00000058427
AA Change: T65S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
SCY 33 93 1e-22 SMART
Meta Mutation Damage Score 0.2988 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,061,864 (GRCm39) S105P possibly damaging Het
Acsm1 T G 7: 119,237,319 (GRCm39) S211A possibly damaging Het
Adam4 T A 12: 81,467,185 (GRCm39) R479* probably null Het
Agap3 A C 5: 24,692,883 (GRCm39) S439R probably damaging Het
Arap1 A T 7: 101,050,141 (GRCm39) H1075L probably benign Het
Arhgef28 T C 13: 98,079,029 (GRCm39) E1299G probably benign Het
Bnip5 T C 17: 29,121,864 (GRCm39) K468E probably benign Het
Cc2d2a A T 5: 43,845,570 (GRCm39) I329F probably damaging Het
Ccdc9b T A 2: 118,591,796 (GRCm39) T115S probably damaging Het
Cd200r1 A G 16: 44,610,084 (GRCm39) N101S probably benign Het
Ces2b A C 8: 105,559,258 (GRCm39) T40P unknown Het
Cfap221 A G 1: 119,909,504 (GRCm39) V156A possibly damaging Het
Chrm4 C T 2: 91,758,563 (GRCm39) P324S probably benign Het
Chrna1 T A 2: 73,400,850 (GRCm39) M227L probably benign Het
Cntln A G 4: 84,952,075 (GRCm39) D639G probably damaging Het
Cts8 A G 13: 61,401,882 (GRCm39) V5A probably benign Het
Cyp2c39 G T 19: 39,552,411 (GRCm39) R368L probably benign Het
D630023F18Rik A T 1: 65,147,939 (GRCm39) S205T probably benign Het
Dagla A T 19: 10,229,401 (GRCm39) probably null Het
Dtnbp1 G A 13: 45,084,615 (GRCm39) T175I probably benign Het
Dtx3 A G 10: 127,026,882 (GRCm39) L332P probably damaging Het
E2f4 A G 8: 106,024,451 (GRCm39) T27A probably damaging Het
Ep400 A G 5: 110,856,758 (GRCm39) F1163L unknown Het
Fam83h ACTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGT ACTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGTAGGGCTCCCCTTGCGCTCAGGGTAAGCTGGGGT 15: 75,874,624 (GRCm39) probably benign Het
Fbxo40 T C 16: 36,790,387 (GRCm39) D241G probably benign Het
Fus T C 7: 127,571,749 (GRCm39) S184P unknown Het
Gabarap C A 11: 69,883,498 (GRCm39) T87N possibly damaging Het
Gbp10 A C 5: 105,372,235 (GRCm39) V175G probably damaging Het
Gcm2 A G 13: 41,256,646 (GRCm39) Y368H probably damaging Het
Heca A G 10: 17,778,011 (GRCm39) Y529H probably damaging Het
Incenp G A 19: 9,852,497 (GRCm39) R714* probably null Het
Lvrn C A 18: 46,983,632 (GRCm39) T125K possibly damaging Het
Ms4a6c T A 19: 11,455,660 (GRCm39) S156R probably benign Het
Nab2 C A 10: 127,502,266 (GRCm39) R21L possibly damaging Het
Neb A T 2: 52,136,827 (GRCm39) M3218K probably benign Het
Nwd2 A G 5: 63,962,663 (GRCm39) D749G probably benign Het
Nxpe5 A T 5: 138,228,804 (GRCm39) Q7L probably benign Het
Or10ak12 T A 4: 118,666,939 (GRCm39) T41S probably benign Het
Or4f62 A T 2: 111,986,598 (GRCm39) M101L probably benign Het
Or5p4 A T 7: 107,680,269 (GRCm39) E89D probably benign Het
Or8g26 A G 9: 39,095,689 (GRCm39) I72V possibly damaging Het
Pla2g5 A G 4: 138,531,917 (GRCm39) I29T probably damaging Het
Prpf31 C T 7: 3,643,917 (GRCm39) T499I probably damaging Het
Rnf130 T A 11: 49,986,623 (GRCm39) D322E probably benign Het
Ros1 T C 10: 51,964,014 (GRCm39) N1770D probably damaging Het
Sacs T A 14: 61,428,548 (GRCm39) D202E probably damaging Het
Simc1 A G 13: 54,674,359 (GRCm39) I902M probably damaging Het
Slc12a8 A T 16: 33,361,348 (GRCm39) M77L probably benign Het
Slc35f2 G A 9: 53,724,224 (GRCm39) G366D probably benign Het
Slc44a2 A G 9: 21,264,984 (GRCm39) D674G probably damaging Het
Smok2a A C 17: 13,445,791 (GRCm39) E456A probably benign Het
Stip1 T C 19: 7,011,618 (GRCm39) N139S probably benign Het
Taar8c C T 10: 23,977,015 (GRCm39) V266M probably benign Het
Tank T A 2: 61,474,758 (GRCm39) I204N possibly damaging Het
Tcerg1 A G 18: 42,694,020 (GRCm39) T714A probably benign Het
Tenm3 A T 8: 48,820,457 (GRCm39) F334I possibly damaging Het
Ubr1 T C 2: 120,693,202 (GRCm39) I1735V probably benign Het
Vps13a A T 19: 16,645,969 (GRCm39) S2023T possibly damaging Het
Wdfy4 T C 14: 32,696,218 (GRCm39) H2741R Het
Wnt10a G T 1: 74,842,376 (GRCm39) R284L probably damaging Het
Other mutations in Cxcl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Cxcl2 APN 5 91,052,211 (GRCm39) splice site probably benign
R1559:Cxcl2 UTSW 5 91,051,871 (GRCm39) missense probably benign 0.00
R1739:Cxcl2 UTSW 5 91,052,017 (GRCm39) missense probably damaging 1.00
R4035:Cxcl2 UTSW 5 91,052,272 (GRCm39) missense possibly damaging 0.69
R4161:Cxcl2 UTSW 5 91,051,881 (GRCm39) splice site probably null
R6558:Cxcl2 UTSW 5 91,052,224 (GRCm39) missense probably damaging 1.00
R7172:Cxcl2 UTSW 5 91,051,879 (GRCm39) missense probably benign 0.00
R8885:Cxcl2 UTSW 5 91,052,085 (GRCm39) nonsense probably null
R9480:Cxcl2 UTSW 5 91,052,029 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- CTGATGTTTCTGGGGAAGCC -3'
(R):5'- CGCGACTCACTTGTTCAGTATC -3'

Sequencing Primer
(F):5'- TGGGGAAGCCTCAGGTG -3'
(R):5'- ATGATTTTCTGAACCAGGGGG -3'
Posted On 2020-07-28