Incidental Mutation 'R8294:S1pr5'
ID 638853
Institutional Source Beutler Lab
Gene Symbol S1pr5
Ensembl Gene ENSMUSG00000045087
Gene Name sphingosine-1-phosphate receptor 5
Synonyms S1P5, Edg8, lpB4
MMRRC Submission 067784-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.360) question?
Stock # R8294 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 21154213-21159739 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21156300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 42 (V42A)
Ref Sequence ENSEMBL: ENSMUSP00000113843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122088]
AlphaFold Q91X56
Predicted Effect possibly damaging
Transcript: ENSMUST00000122088
AA Change: V42A

PolyPhen 2 Score 0.471 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000113843
Gene: ENSMUSG00000045087
AA Change: V42A

DomainStartEndE-ValueType
Pfam:7tm_1 53 307 9.6e-37 PFAM
low complexity region 318 327 N/A INTRINSIC
low complexity region 340 350 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
PHENOTYPE: Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,897,217 (GRCm39) V632A possibly damaging Het
Abcf2 CAT CATAAT 5: 24,781,589 (GRCm39) probably benign Het
Acat2 T C 17: 13,175,243 (GRCm39) I79V probably benign Het
Arid3a A T 10: 79,786,535 (GRCm39) silent Het
Cecr2 C T 6: 120,710,747 (GRCm39) A154V probably damaging Het
Cog3 A C 14: 75,954,619 (GRCm39) L650R probably damaging Het
Col12a1 A T 9: 79,606,594 (GRCm39) F610I possibly damaging Het
Col24a1 A G 3: 145,186,844 (GRCm39) D1215G probably null Het
Ctsh C G 9: 89,950,489 (GRCm39) A219G possibly damaging Het
Dnah10 C T 5: 124,859,410 (GRCm39) L2126F probably damaging Het
Dock10 A G 1: 80,488,079 (GRCm39) V2028A possibly damaging Het
Ece1 T C 4: 137,675,931 (GRCm39) V435A possibly damaging Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
H4c1 A G 13: 23,944,957 (GRCm39) F62L probably damaging Het
Hk1 T G 10: 62,131,624 (GRCm39) I245L probably benign Het
Hyal6 A C 6: 24,734,378 (GRCm39) K104Q possibly damaging Het
Kalrn T C 16: 33,853,954 (GRCm39) I2017V probably benign Het
Khdc4 C T 3: 88,603,915 (GRCm39) A244V probably damaging Het
Krt72 A T 15: 101,694,472 (GRCm39) L141Q probably damaging Het
Map3k4 C A 17: 12,537,500 (GRCm39) A6S unknown Het
Muc6 T C 7: 141,217,263 (GRCm39) Y2470C possibly damaging Het
Nrip1 A G 16: 76,089,418 (GRCm39) V713A probably damaging Het
Or10q1b A G 19: 13,683,010 (GRCm39) D273G probably benign Het
Or11g26 A G 14: 50,753,083 (GRCm39) T141A possibly damaging Het
Or2ah1 T A 2: 85,653,531 (GRCm39) I72N probably damaging Het
Or6aa1 T C 7: 86,044,487 (GRCm39) Y73C probably damaging Het
Paip1 C T 13: 119,587,300 (GRCm39) T304I possibly damaging Het
Pde4dip A G 3: 97,674,694 (GRCm39) L74P probably damaging Het
Prkch T A 12: 73,806,484 (GRCm39) L577H probably damaging Het
Rp1 A G 1: 4,416,220 (GRCm39) S1631P probably benign Het
Rph3a A G 5: 121,099,429 (GRCm39) F154S probably damaging Het
Scaper G A 9: 55,517,280 (GRCm39) L1052F possibly damaging Het
Slc44a2 G T 9: 21,259,643 (GRCm39) V597F probably damaging Het
Srsf1 T A 11: 87,939,467 (GRCm39) S116T probably benign Het
Ssh2 A G 11: 77,345,027 (GRCm39) D1004G probably benign Het
St3gal5 T A 6: 72,074,816 (GRCm39) D25E Het
Syt17 A T 7: 118,009,228 (GRCm39) Y327N probably damaging Het
T T A 17: 8,653,364 (GRCm39) M1K probably null Het
Tmem201 A T 4: 149,815,554 (GRCm39) I132N possibly damaging Het
Tmprss15 A T 16: 78,868,176 (GRCm39) C211S probably benign Het
Trim36 T C 18: 46,331,588 (GRCm39) D7G probably benign Het
Trip11 T A 12: 101,811,160 (GRCm39) K1863N possibly damaging Het
Vmn2r13 A T 5: 109,322,978 (GRCm39) S104T probably benign Het
Zfp977 T C 7: 42,229,689 (GRCm39) T279A probably benign Het
Other mutations in S1pr5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:S1pr5 APN 9 21,155,512 (GRCm39) missense possibly damaging 0.55
IGL01719:S1pr5 APN 9 21,155,250 (GRCm39) missense probably benign 0.03
sipho UTSW 9 21,155,425 (GRCm39) missense probably benign 0.01
R0392:S1pr5 UTSW 9 21,156,277 (GRCm39) missense probably damaging 1.00
R0448:S1pr5 UTSW 9 21,155,503 (GRCm39) missense probably damaging 1.00
R1599:S1pr5 UTSW 9 21,155,230 (GRCm39) missense probably benign 0.02
R1703:S1pr5 UTSW 9 21,155,346 (GRCm39) missense possibly damaging 0.52
R1850:S1pr5 UTSW 9 21,155,425 (GRCm39) missense probably benign 0.01
R2095:S1pr5 UTSW 9 21,156,154 (GRCm39) missense probably benign 0.04
R2178:S1pr5 UTSW 9 21,155,760 (GRCm39) missense probably benign 0.36
R3082:S1pr5 UTSW 9 21,156,286 (GRCm39) missense probably damaging 1.00
R3430:S1pr5 UTSW 9 21,156,378 (GRCm39) missense probably benign 0.00
R5578:S1pr5 UTSW 9 21,155,847 (GRCm39) missense probably damaging 1.00
R7444:S1pr5 UTSW 9 21,156,378 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CTCTAAAGCAATGGCCAAGAGG -3'
(R):5'- AGACTTTTGCACAGTGCTCCAG -3'

Sequencing Primer
(F):5'- AAGAGGCTCAGCACCGACG -3'
(R):5'- ACAGTGCTCCAGTGGACGAC -3'
Posted On 2020-07-28