Incidental Mutation 'R8294:Or10q1b'
ID 638875
Institutional Source Beutler Lab
Gene Symbol Or10q1b
Ensembl Gene ENSMUSG00000051156
Gene Name olfactory receptor family 10 subfamily Q member 1B
Synonyms MOR266-8, Olfr1491, GA_x6K02T2RE5P-4037809-4038768
MMRRC Submission 067784-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8294 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13682193-13683152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13683010 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 273 (D273G)
Ref Sequence ENSEMBL: ENSMUSP00000057902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052737]
AlphaFold Q8VEZ5
Predicted Effect probably benign
Transcript: ENSMUST00000052737
AA Change: D273G

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000057902
Gene: ENSMUSG00000051156
AA Change: D273G

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 3.3e-52 PFAM
Pfam:7tm_1 45 295 5.9e-24 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,897,217 (GRCm39) V632A possibly damaging Het
Abcf2 CAT CATAAT 5: 24,781,589 (GRCm39) probably benign Het
Acat2 T C 17: 13,175,243 (GRCm39) I79V probably benign Het
Arid3a A T 10: 79,786,535 (GRCm39) silent Het
Cecr2 C T 6: 120,710,747 (GRCm39) A154V probably damaging Het
Cog3 A C 14: 75,954,619 (GRCm39) L650R probably damaging Het
Col12a1 A T 9: 79,606,594 (GRCm39) F610I possibly damaging Het
Col24a1 A G 3: 145,186,844 (GRCm39) D1215G probably null Het
Ctsh C G 9: 89,950,489 (GRCm39) A219G possibly damaging Het
Dnah10 C T 5: 124,859,410 (GRCm39) L2126F probably damaging Het
Dock10 A G 1: 80,488,079 (GRCm39) V2028A possibly damaging Het
Ece1 T C 4: 137,675,931 (GRCm39) V435A possibly damaging Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
H4c1 A G 13: 23,944,957 (GRCm39) F62L probably damaging Het
Hk1 T G 10: 62,131,624 (GRCm39) I245L probably benign Het
Hyal6 A C 6: 24,734,378 (GRCm39) K104Q possibly damaging Het
Kalrn T C 16: 33,853,954 (GRCm39) I2017V probably benign Het
Khdc4 C T 3: 88,603,915 (GRCm39) A244V probably damaging Het
Krt72 A T 15: 101,694,472 (GRCm39) L141Q probably damaging Het
Map3k4 C A 17: 12,537,500 (GRCm39) A6S unknown Het
Muc6 T C 7: 141,217,263 (GRCm39) Y2470C possibly damaging Het
Nrip1 A G 16: 76,089,418 (GRCm39) V713A probably damaging Het
Or11g26 A G 14: 50,753,083 (GRCm39) T141A possibly damaging Het
Or2ah1 T A 2: 85,653,531 (GRCm39) I72N probably damaging Het
Or6aa1 T C 7: 86,044,487 (GRCm39) Y73C probably damaging Het
Paip1 C T 13: 119,587,300 (GRCm39) T304I possibly damaging Het
Pde4dip A G 3: 97,674,694 (GRCm39) L74P probably damaging Het
Prkch T A 12: 73,806,484 (GRCm39) L577H probably damaging Het
Rp1 A G 1: 4,416,220 (GRCm39) S1631P probably benign Het
Rph3a A G 5: 121,099,429 (GRCm39) F154S probably damaging Het
S1pr5 A G 9: 21,156,300 (GRCm39) V42A possibly damaging Het
Scaper G A 9: 55,517,280 (GRCm39) L1052F possibly damaging Het
Slc44a2 G T 9: 21,259,643 (GRCm39) V597F probably damaging Het
Srsf1 T A 11: 87,939,467 (GRCm39) S116T probably benign Het
Ssh2 A G 11: 77,345,027 (GRCm39) D1004G probably benign Het
St3gal5 T A 6: 72,074,816 (GRCm39) D25E Het
Syt17 A T 7: 118,009,228 (GRCm39) Y327N probably damaging Het
T T A 17: 8,653,364 (GRCm39) M1K probably null Het
Tmem201 A T 4: 149,815,554 (GRCm39) I132N possibly damaging Het
Tmprss15 A T 16: 78,868,176 (GRCm39) C211S probably benign Het
Trim36 T C 18: 46,331,588 (GRCm39) D7G probably benign Het
Trip11 T A 12: 101,811,160 (GRCm39) K1863N possibly damaging Het
Vmn2r13 A T 5: 109,322,978 (GRCm39) S104T probably benign Het
Zfp977 T C 7: 42,229,689 (GRCm39) T279A probably benign Het
Other mutations in Or10q1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or10q1b APN 19 13,683,096 (GRCm39) missense probably benign 0.05
IGL02713:Or10q1b APN 19 13,682,553 (GRCm39) missense possibly damaging 0.78
IGL02822:Or10q1b APN 19 13,683,019 (GRCm39) missense probably benign 0.13
R0083:Or10q1b UTSW 19 13,683,042 (GRCm39) missense probably damaging 0.99
R0108:Or10q1b UTSW 19 13,683,042 (GRCm39) missense probably damaging 0.99
R0271:Or10q1b UTSW 19 13,682,499 (GRCm39) missense probably benign 0.03
R1364:Or10q1b UTSW 19 13,682,809 (GRCm39) missense probably benign 0.11
R1538:Or10q1b UTSW 19 13,682,860 (GRCm39) missense probably damaging 1.00
R1575:Or10q1b UTSW 19 13,682,889 (GRCm39) missense probably benign 0.00
R1579:Or10q1b UTSW 19 13,682,566 (GRCm39) missense probably damaging 1.00
R2179:Or10q1b UTSW 19 13,682,758 (GRCm39) missense probably damaging 0.98
R4393:Or10q1b UTSW 19 13,682,554 (GRCm39) missense possibly damaging 0.50
R5837:Or10q1b UTSW 19 13,682,324 (GRCm39) nonsense probably null
R6001:Or10q1b UTSW 19 13,682,424 (GRCm39) missense probably damaging 0.98
R8064:Or10q1b UTSW 19 13,682,386 (GRCm39) missense probably damaging 1.00
R8132:Or10q1b UTSW 19 13,682,584 (GRCm39) missense probably damaging 1.00
R8380:Or10q1b UTSW 19 13,682,608 (GRCm39) missense probably benign 0.11
R9608:Or10q1b UTSW 19 13,682,868 (GRCm39) missense probably damaging 1.00
Z1176:Or10q1b UTSW 19 13,682,567 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACATTCATGTGCACCAGGC -3'
(R):5'- ACACATGTTTCTTGCTATGACCTG -3'

Sequencing Primer
(F):5'- AGTCCTCTACGTAGTGGGCATC -3'
(R):5'- GACCTGAAGCCTTTAACTACAGTGAG -3'
Posted On 2020-07-28