Mutagenetix > Incidental Mutation

Incidental Mutation 'R0697:Vmn1r84'

63891

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r84

Ensembl Gene

ENSMUSG00000066803

Gene Name

vomeronasal 1 receptor 84

Synonyms

V1rg11

MMRRC Submission

038881-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R0697 (G1)

Quality Score

100

Status

Not validated

Chromosome

Chromosomal Location

12360313-12369273 bp(-) (GRCm38)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 12362763 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000083405 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086228] [ENSMUST00000226408] [ENSMUST00000227427] [ENSMUST00000228653]

AlphaFold

Q8R284

Predicted Effect

probably null
Transcript: ENSMUST00000086228
AA Change: M1K

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000083405
Gene: ENSMUSG00000066803
AA Change: M1K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	16	312	3.7e-11	PFAM
Pfam:V1R	45	308	1.9e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177845

Predicted Effect

probably benign
Transcript: ENSMUST00000226408

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226811

Predicted Effect

probably benign
Transcript: ENSMUST00000227427

Predicted Effect

probably benign
Transcript: ENSMUST00000228653

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228741

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	C	A	19: 31,911,167	A99E	probably damaging	Het
Aig1	T	C	10: 13,829,325	N72S	probably benign	Het
Atad2	T	C	15: 58,105,543	I857M	possibly damaging	Het
Ceacam15	A	C	7: 16,673,520	L24*	probably null	Het
Cpsf2	A	G	12: 101,983,184	H53R	probably benign	Het
Crh	C	A	3: 19,694,077	G134C	probably damaging	Het
Cyp2g1	A	T	7: 26,814,727	K253*	probably null	Het
Dna2	T	C	10: 62,949,341	V79A	probably benign	Het
Dsc2	A	G	18: 20,041,452	V549A	probably damaging	Het
Etl4	G	T	2: 20,743,861	V135F	probably damaging	Het
Frk	A	G	10: 34,607,837	H398R	probably benign	Het
Gfra1	A	C	19: 58,270,123	S271A	probably benign	Het
Htr1b	T	C	9: 81,631,463	I364V	possibly damaging	Het
Kcnh5	A	T	12: 74,976,531	C588S	possibly damaging	Het
Kif13a	G	A	13: 46,848,337	T70I	probably benign	Het
Klra6	T	C	6: 130,016,724	I195V	probably benign	Het
Nras	T	C	3: 103,060,300	Y71H	possibly damaging	Het
Sirt5	T	C	13: 43,385,576	F274L	probably damaging	Het
Synj1	T	C	16: 90,960,615	T882A	probably benign	Het
Zfhx4	A	T	3: 5,401,733	E2317V	probably damaging	Het
Zfp345	A	T	2: 150,472,909	I236K	probably benign	Het

Other mutations in Vmn1r84

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02505:Vmn1r84	APN	7	12362419	missense	probably damaging	1.00
K3955:Vmn1r84	UTSW	7	12361957	missense	probably damaging	0.98
R0360:Vmn1r84	UTSW	7	12361872	missense	probably damaging	1.00
R0399:Vmn1r84	UTSW	7	12361867	missense	probably benign	0.26
R1613:Vmn1r84	UTSW	7	12362533	missense	possibly damaging	0.80
R1636:Vmn1r84	UTSW	7	12362595	missense	probably benign	0.12
R1872:Vmn1r84	UTSW	7	12362628	missense	probably benign	0.17
R4022:Vmn1r84	UTSW	7	12361930	missense	probably benign
R4923:Vmn1r84	UTSW	7	12361816	missense	probably benign
R5189:Vmn1r84	UTSW	7	12362458	missense	probably benign	0.10
R5275:Vmn1r84	UTSW	7	12361814	missense	probably benign
R5721:Vmn1r84	UTSW	7	12362226	missense	probably damaging	1.00
R6151:Vmn1r84	UTSW	7	12361914	missense	possibly damaging	0.72
R7261:Vmn1r84	UTSW	7	12362142	missense	probably damaging	1.00
R7513:Vmn1r84	UTSW	7	12362067	missense	probably benign	0.00
R7573:Vmn1r84	UTSW	7	12361860	missense	probably benign	0.17
R8039:Vmn1r84	UTSW	7	12362008	missense	possibly damaging	0.67
R8814:Vmn1r84	UTSW	7	12362458	missense	probably damaging	0.99
Z1177:Vmn1r84	UTSW	7	12362659	missense	possibly damaging	0.92
Z1177:Vmn1r84	UTSW	7	12362512	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCAACCCCAGTTGTACCATTATGTGAG -3'
(R):5'- GCTGGATTACAGGAGTGAATCAGGTC -3'

Sequencing Primer
(F):5'- CTTGAGATAATAACCAAGGAATTGGC -3'
(R):5'- TTACAGGAGTGAATCAGGTCTACTG -3'

Posted On

2013-07-30