Incidental Mutation 'R0697:Cyp2g1'
| ID |
63894 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cyp2g1
|
| Ensembl Gene |
ENSMUSG00000049685 |
| Gene Name |
cytochrome P450, family 2, subfamily g, polypeptide 1 |
| Synonyms |
|
| MMRRC Submission |
038881-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0697 (G1)
|
| Quality Score |
118 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
26508352-26520622 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 26514152 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 253
(K253*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047150
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040944]
|
| AlphaFold |
Q9WV19 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000040944
AA Change: K253*
|
| SMART Domains |
Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685
AA Change: K253*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
12 |
23 |
N/A |
INTRINSIC |
|
Pfam:p450
|
34 |
491 |
4e-150 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205273
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
C |
A |
19: 31,888,567 (GRCm39) |
A99E |
probably damaging |
Het |
| Aig1 |
T |
C |
10: 13,705,069 (GRCm39) |
N72S |
probably benign |
Het |
| Atad2 |
T |
C |
15: 57,968,939 (GRCm39) |
I857M |
possibly damaging |
Het |
| Ceacam15 |
A |
C |
7: 16,407,445 (GRCm39) |
L24* |
probably null |
Het |
| Cpsf2 |
A |
G |
12: 101,949,443 (GRCm39) |
H53R |
probably benign |
Het |
| Crh |
C |
A |
3: 19,748,241 (GRCm39) |
G134C |
probably damaging |
Het |
| Dna2 |
T |
C |
10: 62,785,120 (GRCm39) |
V79A |
probably benign |
Het |
| Dsc2 |
A |
G |
18: 20,174,509 (GRCm39) |
V549A |
probably damaging |
Het |
| Etl4 |
G |
T |
2: 20,748,672 (GRCm39) |
V135F |
probably damaging |
Het |
| Frk |
A |
G |
10: 34,483,833 (GRCm39) |
H398R |
probably benign |
Het |
| Gfra1 |
A |
C |
19: 58,258,555 (GRCm39) |
S271A |
probably benign |
Het |
| Htr1b |
T |
C |
9: 81,513,516 (GRCm39) |
I364V |
possibly damaging |
Het |
| Kcnh5 |
A |
T |
12: 75,023,305 (GRCm39) |
C588S |
possibly damaging |
Het |
| Kif13a |
G |
A |
13: 47,001,813 (GRCm39) |
T70I |
probably benign |
Het |
| Klra6 |
T |
C |
6: 129,993,687 (GRCm39) |
I195V |
probably benign |
Het |
| Nras |
T |
C |
3: 102,967,616 (GRCm39) |
Y71H |
possibly damaging |
Het |
| Sirt5 |
T |
C |
13: 43,539,052 (GRCm39) |
F274L |
probably damaging |
Het |
| Synj1 |
T |
C |
16: 90,757,503 (GRCm39) |
T882A |
probably benign |
Het |
| Vmn1r84 |
A |
T |
7: 12,096,690 (GRCm39) |
M1K |
probably null |
Het |
| Zfhx4 |
A |
T |
3: 5,466,793 (GRCm39) |
E2317V |
probably damaging |
Het |
| Zfp345 |
A |
T |
2: 150,314,829 (GRCm39) |
I236K |
probably benign |
Het |
|
| Other mutations in Cyp2g1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01134:Cyp2g1
|
APN |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01137:Cyp2g1
|
APN |
7 |
26,513,684 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02052:Cyp2g1
|
APN |
7 |
26,513,719 (GRCm39) |
splice site |
probably benign |
|
|
IGL02338:Cyp2g1
|
APN |
7 |
26,514,229 (GRCm39) |
splice site |
probably benign |
|
|
IGL02452:Cyp2g1
|
APN |
7 |
26,510,871 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02523:Cyp2g1
|
APN |
7 |
26,518,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03165:Cyp2g1
|
APN |
7 |
26,509,201 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03230:Cyp2g1
|
APN |
7 |
26,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Cyp2g1
|
UTSW |
7 |
26,513,619 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Cyp2g1
|
UTSW |
7 |
26,513,720 (GRCm39) |
splice site |
probably benign |
|
|
R0830:Cyp2g1
|
UTSW |
7 |
26,514,216 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1660:Cyp2g1
|
UTSW |
7 |
26,509,107 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2093:Cyp2g1
|
UTSW |
7 |
26,518,858 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2131:Cyp2g1
|
UTSW |
7 |
26,520,135 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4606:Cyp2g1
|
UTSW |
7 |
26,513,579 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5030:Cyp2g1
|
UTSW |
7 |
26,520,226 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5574:Cyp2g1
|
UTSW |
7 |
26,520,165 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5877:Cyp2g1
|
UTSW |
7 |
26,516,065 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6745:Cyp2g1
|
UTSW |
7 |
26,513,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Cyp2g1
|
UTSW |
7 |
26,520,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Cyp2g1
|
UTSW |
7 |
26,514,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7934:Cyp2g1
|
UTSW |
7 |
26,518,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8112:Cyp2g1
|
UTSW |
7 |
26,518,886 (GRCm39) |
missense |
probably benign |
|
|
R8177:Cyp2g1
|
UTSW |
7 |
26,518,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8194:Cyp2g1
|
UTSW |
7 |
26,514,159 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9043:Cyp2g1
|
UTSW |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9406:Cyp2g1
|
UTSW |
7 |
26,518,910 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9441:Cyp2g1
|
UTSW |
7 |
26,514,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
X0067:Cyp2g1
|
UTSW |
7 |
26,520,187 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAACGCTTCGACTATCAGGACCAG -3'
(R):5'- ATGAAACAGTACTTTCCCTTGTCACCC -3'
Sequencing Primer
(F):5'- gccttgaactgctgatccc -3'
(R):5'- CCCACCCCCATAGTTGTAGATG -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation