|Institutional Source||Beutler Lab|
|Gene Name||phosphodiesterase 4A, cAMP specific|
|Synonyms||Dpde2, dunce, D9Ertd60e|
|Is this an essential gene?||Probably non essential (E-score: 0.201)|
|Stock #||R8297 (G1)|
|Chromosomal Location||21165714-21213248 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 21166108 bp|
|Amino Acid Change||Proline to Serine at position 61 (P61S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000037025 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000039413]|
|Predicted Effect||possibly damaging
AA Change: P61S
PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
AA Change: P61S
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
PHENOTYPE: Homozygous null mice have a normal phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pde4a||
(F):5'- ACAGGCCAGGGGACGTTTT -3'
(R):5'- AAAGGGCTTCTGGTGCAG -3'
(F):5'- ACGTTTTTGCCCCCGGG -3'
(R):5'- TTTGGCCAGCATTGCGC -3'