Incidental Mutation 'R8298:Dyrk3'
ID 639052
Institutional Source Beutler Lab
Gene Symbol Dyrk3
Ensembl Gene ENSMUSG00000016526
Gene Name dual-specificity tyrosine phosphorylation regulated kinase 3
Synonyms
MMRRC Submission 067786-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.283) question?
Stock # R8298 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 131056178-131065991 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 131057112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 354 (D354N)
Ref Sequence ENSEMBL: ENSMUSP00000016670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016670] [ENSMUST00000189756]
AlphaFold Q922Y0
Predicted Effect probably damaging
Transcript: ENSMUST00000016670
AA Change: D354N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000016670
Gene: ENSMUSG00000016526
AA Change: D354N

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
S_TKc 208 521 2.45e-91 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000189756
SMART Domains Protein: ENSMUSP00000140050
Gene: ENSMUSG00000016526

DomainStartEndE-ValueType
PDB:4AZF|A 101 152 3e-18 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (62/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit increased erythropoiesis in response to chemically-induced anemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik A G 16: 64,586,695 (GRCm39) L343P probably benign Het
Aak1 T A 6: 86,902,061 (GRCm39) F77I possibly damaging Het
Abca3 T C 17: 24,604,375 (GRCm39) L582P probably damaging Het
Acat1 A T 9: 53,505,724 (GRCm39) S136R probably damaging Het
Adamts2 T C 11: 50,667,958 (GRCm39) F507L possibly damaging Het
Adcy3 G A 12: 4,256,482 (GRCm39) A763T probably damaging Het
Adgrv1 A T 13: 81,534,033 (GRCm39) C5849* probably null Het
Adrb2 A T 18: 62,311,753 (GRCm39) N357K probably benign Het
Ak9 A G 10: 41,265,054 (GRCm39) E404G Het
Akap13 T C 7: 75,397,552 (GRCm39) L2576P probably damaging Het
Armcx5 AGACAAAGCTAAAGAGGTCTGTGTCAAATCCAGGGCTGGGGACAAAGCTAAAGAGGTCTGTGTCAAATCCAGGGCTGGGGACAAAGCTA AGACAAAGCTAAAGAGGTCTGTGTCAAATCCAGGGCTGGGGACAAAGCTA X: 134,646,453 (GRCm39) probably benign Het
Arv1 A G 8: 125,455,111 (GRCm39) Y108C probably damaging Het
Casp8ap2 T A 4: 32,640,429 (GRCm39) H494Q probably benign Het
Ccdc88b A G 19: 6,827,649 (GRCm39) L951P probably damaging Het
D830039M14Rik A T 10: 61,311,362 (GRCm39) M160K noncoding transcript Het
Dbf4 A G 5: 8,462,115 (GRCm39) probably benign Het
Dennd4a A G 9: 64,814,157 (GRCm39) D1458G probably benign Het
Dock10 T C 1: 80,514,654 (GRCm39) K1422R probably benign Het
Epha3 T A 16: 63,386,961 (GRCm39) I892F probably benign Het
Evi5 G A 5: 107,964,731 (GRCm39) S317L possibly damaging Het
Evl C T 12: 108,619,232 (GRCm39) P76S probably benign Het
Fyb2 A C 4: 104,806,028 (GRCm39) E369D probably damaging Het
Gm10000 T C 12: 104,442,436 (GRCm39) probably benign Het
Gm1979 T C 5: 26,206,148 (GRCm39) N190S probably damaging Het
Gm3633 T C 14: 42,462,675 (GRCm39) E72G Het
Gm5414 T C 15: 101,532,605 (GRCm39) Y506C unknown Het
Gm572 T A 4: 148,742,550 (GRCm39) H96Q possibly damaging Het
Gml T C 15: 74,685,541 (GRCm39) E148G probably damaging Het
Got1l1 T C 8: 27,688,586 (GRCm39) D255G probably benign Het
Hydin A G 8: 111,327,015 (GRCm39) N4785D probably damaging Het
Kcnk12 A T 17: 88,104,713 (GRCm39) F57Y probably damaging Het
Klhdc9 C A 1: 171,186,429 (GRCm39) G336C probably damaging Het
Kprp T C 3: 92,732,607 (GRCm39) T148A probably damaging Het
Lama3 G A 18: 12,658,910 (GRCm39) R2022Q probably benign Het
Lelp1 A T 3: 92,042,927 (GRCm39) S41T unknown Het
Lnx2 A T 5: 146,961,327 (GRCm39) M535K probably benign Het
Mmp9 T A 2: 164,792,279 (GRCm39) F294L probably null Het
Myo7a T C 7: 97,747,541 (GRCm39) Y97C probably damaging Het
Nav2 T C 7: 49,204,009 (GRCm39) probably null Het
Ndufaf3 T C 9: 108,444,120 (GRCm39) T3A probably benign Het
Nrxn1 A G 17: 91,011,597 (GRCm39) I344T probably damaging Het
Or1j1 T C 2: 36,703,038 (GRCm39) E22G probably benign Het
Or5ap2 T C 2: 85,680,533 (GRCm39) S246P probably damaging Het
Or5w14 A T 2: 87,541,376 (GRCm39) S291R probably damaging Het
Pccb T C 9: 100,867,885 (GRCm39) D384G probably damaging Het
Plekhg3 C T 12: 76,623,852 (GRCm39) H1032Y probably damaging Het
Ppfia3 A G 7: 45,009,618 (GRCm39) S125P probably damaging Het
Prl7a2 T C 13: 27,844,994 (GRCm39) M131V probably benign Het
Prmt3 A G 7: 49,507,186 (GRCm39) T517A probably benign Het
Prpf4b A G 13: 35,072,166 (GRCm39) H491R unknown Het
Rhot1 T A 11: 80,137,502 (GRCm39) C335S probably benign Het
Robo1 C T 16: 72,769,020 (GRCm39) probably benign Het
Samd3 A T 10: 26,121,468 (GRCm39) D195V probably damaging Het
Sh3gl2 T A 4: 85,297,647 (GRCm39) D208E possibly damaging Het
Spta1 A T 1: 174,074,953 (GRCm39) D2393V probably damaging Het
Tgs1 T C 4: 3,605,840 (GRCm39) L785P probably damaging Het
Tmem25 C T 9: 44,710,116 (GRCm39) probably benign Het
Trappc10 A G 10: 78,038,753 (GRCm39) Y780H probably damaging Het
Ttn C A 2: 76,557,511 (GRCm39) W29861L probably damaging Het
Usp1 T A 4: 98,819,136 (GRCm39) D199E probably damaging Het
Vmn2r40 A G 7: 8,911,148 (GRCm39) I715T Het
Zfp169 G A 13: 48,651,853 (GRCm39) Q68* probably null Het
Zfp418 T A 7: 7,185,814 (GRCm39) Y592* probably null Het
Zfp712 A G 13: 67,188,976 (GRCm39) V517A probably benign Het
Zfp934 A T 13: 62,666,295 (GRCm39) H146Q Het
Zgrf1 T C 3: 127,408,878 (GRCm39) S1662P probably damaging Het
Other mutations in Dyrk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Dyrk3 APN 1 131,064,074 (GRCm39) missense possibly damaging 0.71
IGL00910:Dyrk3 APN 1 131,064,073 (GRCm39) missense possibly damaging 0.92
IGL02436:Dyrk3 APN 1 131,056,602 (GRCm39) missense probably benign 0.00
IGL03057:Dyrk3 APN 1 131,056,815 (GRCm39) missense probably benign 0.01
PIT4576001:Dyrk3 UTSW 1 131,057,918 (GRCm39) missense probably damaging 0.98
R0116:Dyrk3 UTSW 1 131,057,576 (GRCm39) missense probably damaging 1.00
R0361:Dyrk3 UTSW 1 131,057,769 (GRCm39) missense probably benign 0.00
R0457:Dyrk3 UTSW 1 131,064,094 (GRCm39) missense possibly damaging 0.94
R0529:Dyrk3 UTSW 1 131,057,858 (GRCm39) missense probably benign 0.00
R0724:Dyrk3 UTSW 1 131,057,877 (GRCm39) missense probably benign 0.00
R1116:Dyrk3 UTSW 1 131,056,919 (GRCm39) missense probably damaging 1.00
R2999:Dyrk3 UTSW 1 131,057,183 (GRCm39) missense probably damaging 1.00
R3423:Dyrk3 UTSW 1 131,057,219 (GRCm39) missense probably damaging 1.00
R4591:Dyrk3 UTSW 1 131,057,895 (GRCm39) missense probably damaging 1.00
R5358:Dyrk3 UTSW 1 131,057,432 (GRCm39) missense probably damaging 1.00
R5608:Dyrk3 UTSW 1 131,056,452 (GRCm39) missense probably benign
R6767:Dyrk3 UTSW 1 131,057,327 (GRCm39) missense probably damaging 0.99
R7072:Dyrk3 UTSW 1 131,057,465 (GRCm39) missense probably damaging 1.00
R7744:Dyrk3 UTSW 1 131,057,543 (GRCm39) missense probably damaging 1.00
R7775:Dyrk3 UTSW 1 131,057,364 (GRCm39) missense possibly damaging 0.84
R7909:Dyrk3 UTSW 1 131,057,324 (GRCm39) missense probably damaging 1.00
R7961:Dyrk3 UTSW 1 131,063,995 (GRCm39) critical splice donor site probably null
R8009:Dyrk3 UTSW 1 131,063,995 (GRCm39) critical splice donor site probably null
R8930:Dyrk3 UTSW 1 131,057,293 (GRCm39) missense probably damaging 1.00
R8932:Dyrk3 UTSW 1 131,057,293 (GRCm39) missense probably damaging 1.00
Z1088:Dyrk3 UTSW 1 131,056,970 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAACTCTATCATGCAGGCC -3'
(R):5'- CTGCTAAGCATAGACCTGTATGAGC -3'

Sequencing Primer
(F):5'- GGCCAACTGGTCTCCTTCG -3'
(R):5'- GGACGCTCTGCACAAAAA -3'
Posted On 2020-07-28