Incidental Mutation 'R8303:Or4c11c'
ID 639304
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 067715-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8303 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88661633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 57 (M57I)
Ref Sequence ENSEMBL: ENSMUSP00000075769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000076438
AA Change: M57I

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: M57I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215929
AA Change: M57I

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T A 11: 58,770,966 (GRCm39) D149E probably benign Het
Aars2 T C 17: 45,818,523 (GRCm39) C103R probably damaging Het
Aass T C 6: 23,092,367 (GRCm39) D591G probably benign Het
Arhgap32 A G 9: 32,172,205 (GRCm39) T1662A probably benign Het
Arhgap42 A T 9: 9,009,327 (GRCm39) I520N probably damaging Het
Arhgef3 T C 14: 27,116,095 (GRCm39) I279T probably damaging Het
Arid4b A G 13: 14,294,808 (GRCm39) K30R probably damaging Het
Asxl3 C T 18: 22,657,473 (GRCm39) R1828W probably benign Het
Bid T C 6: 120,877,200 (GRCm39) Y47C probably benign Het
Card6 T C 15: 5,134,847 (GRCm39) T119A probably benign Het
Cbr1 T C 16: 93,406,905 (GRCm39) I207T probably damaging Het
Cep135 T C 5: 76,759,575 (GRCm39) L443P probably damaging Het
Cfap251 T A 5: 123,460,650 (GRCm39) V1204E probably damaging Het
Cfap43 T A 19: 47,754,274 (GRCm39) R1017* probably null Het
Cfap52 T A 11: 67,830,621 (GRCm39) S280C probably benign Het
Cntnap5b T C 1: 100,069,022 (GRCm39) F81L probably damaging Het
Cyp4a12a A G 4: 115,186,130 (GRCm39) D430G probably damaging Het
Cyp4f37 G A 17: 32,853,152 (GRCm39) probably null Het
Dclre1a A G 19: 56,531,121 (GRCm39) S742P probably damaging Het
Ddx54 T C 5: 120,759,855 (GRCm39) F414S probably damaging Het
Dsp A G 13: 38,381,319 (GRCm39) N2688S probably benign Het
Elovl4 A T 9: 83,670,320 (GRCm39) probably null Het
Erbin A C 13: 103,966,694 (GRCm39) probably null Het
Fsip2 A G 2: 82,818,724 (GRCm39) D4819G probably benign Het
Gapvd1 G A 2: 34,602,212 (GRCm39) P645L probably damaging Het
Gbp9 T C 5: 105,229,171 (GRCm39) E492G possibly damaging Het
Gpc5 T A 14: 115,665,667 (GRCm39) I497K probably benign Het
Hlx A G 1: 184,459,905 (GRCm39) L411P probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Ice1 A T 13: 70,754,526 (GRCm39) I520N probably benign Het
Ist1 T C 8: 110,410,412 (GRCm39) probably null Het
Itga3 T C 11: 94,953,466 (GRCm39) D292G probably benign Het
Kif21a T C 15: 90,855,399 (GRCm39) N655S probably damaging Het
Lrrtm1 A G 6: 77,221,662 (GRCm39) H373R probably benign Het
Ngdn A T 14: 55,260,602 (GRCm39) H270L probably benign Het
Nol4 G A 18: 23,173,231 (GRCm39) probably benign Het
Nup50l T C 6: 96,142,702 (GRCm39) E114G probably benign Het
Nxpe5 G A 5: 138,239,264 (GRCm39) probably benign Het
Or1j18 A G 2: 36,624,467 (GRCm39) I45V probably damaging Het
Or8d1 A C 9: 38,766,837 (GRCm39) T160P probably damaging Het
Or8g30 A C 9: 39,230,689 (GRCm39) S74A probably damaging Het
Pask C A 1: 93,248,286 (GRCm39) R1005L probably benign Het
Pcm1 A G 8: 41,736,758 (GRCm39) T875A probably damaging Het
Pdrg1 A T 2: 152,851,587 (GRCm39) I130N probably damaging Het
Plec A T 15: 76,073,466 (GRCm39) M448K unknown Het
R3hdml T G 2: 163,341,832 (GRCm39) V204G probably damaging Het
Rasa4 G A 5: 136,118,235 (GRCm39) V32M possibly damaging Het
Scaf8 T C 17: 3,198,827 (GRCm39) V44A unknown Het
Smad3 G T 9: 63,574,760 (GRCm39) P177T probably benign Het
Smpd4 T A 16: 17,457,195 (GRCm39) F384L probably damaging Het
Sycp2l G C 13: 41,283,275 (GRCm39) L170F probably damaging Het
Tas2r107 T C 6: 131,636,585 (GRCm39) S155G probably benign Het
Tmem143 T A 7: 45,565,994 (GRCm39) M439K probably benign Het
Ttc41 A T 10: 86,555,494 (GRCm39) T317S probably benign Het
Umps A G 16: 33,784,240 (GRCm39) V71A possibly damaging Het
Usp17lc G A 7: 103,067,389 (GRCm39) G228D possibly damaging Het
Usp17ld C T 7: 102,900,023 (GRCm39) C303Y probably damaging Het
Vmn2r65 C A 7: 84,589,391 (GRCm39) E842* probably null Het
Vmn2r94 A G 17: 18,464,433 (GRCm39) F619S probably damaging Het
Vps13a T C 19: 16,594,270 (GRCm39) T3154A probably benign Het
Vps13b C T 15: 35,640,063 (GRCm39) T1311I probably damaging Het
Xpot A T 10: 121,447,405 (GRCm39) Y353* probably null Het
Zfp319 A T 8: 96,055,765 (GRCm39) L146Q probably damaging Het
Zfp422 T A 6: 116,603,612 (GRCm39) H129L probably damaging Het
Zzef1 T C 11: 72,808,015 (GRCm39) F2709L probably damaging Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTCTTGGACTGACACAATGC -3'
(R):5'- AAGGGTTTACAGATGGCCAC -3'

Sequencing Primer
(F):5'- CTTGGACTGACACAATGCAGCAG -3'
(R):5'- GTTTACAGATGGCCACATAACGGTC -3'
Posted On 2020-07-28