Incidental Mutation 'R0005:Slc35f4'
ID 63940
Institutional Source Beutler Lab
Gene Symbol Slc35f4
Ensembl Gene ENSMUSG00000021852
Gene Name solute carrier family 35, member F4
Synonyms 4930550L21Rik
MMRRC Submission 038301-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # R0005 (G1)
Quality Score 124
Status Validated
Chromosome 14
Chromosomal Location 49535976-49763354 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 49559943 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074368] [ENSMUST00000123534] [ENSMUST00000138884] [ENSMUST00000146164]
AlphaFold Q8BZK4
Predicted Effect probably benign
Transcript: ENSMUST00000074368
SMART Domains Protein: ENSMUSP00000073972
Gene: ENSMUSG00000021852

DomainStartEndE-ValueType
low complexity region 22 30 N/A INTRINSIC
transmembrane domain 123 145 N/A INTRINSIC
transmembrane domain 160 182 N/A INTRINSIC
Pfam:SLC35F 216 435 7.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123534
SMART Domains Protein: ENSMUSP00000122405
Gene: ENSMUSG00000021852

DomainStartEndE-ValueType
low complexity region 22 30 N/A INTRINSIC
transmembrane domain 123 145 N/A INTRINSIC
transmembrane domain 160 182 N/A INTRINSIC
transmembrane domain 217 234 N/A INTRINSIC
transmembrane domain 239 261 N/A INTRINSIC
transmembrane domain 274 296 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138884
SMART Domains Protein: ENSMUSP00000119007
Gene: ENSMUSG00000021852

DomainStartEndE-ValueType
Pfam:EmrE 18 143 1e-12 PFAM
Pfam:EamA 57 135 8.4e-9 PFAM
Pfam:DUF914 68 314 4.8e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146164
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn2l A G 7: 126,097,446 (GRCm39) F201L probably damaging Het
Camsap3 T A 8: 3,654,288 (GRCm39) F653I probably damaging Het
Cemip2 A G 19: 21,789,584 (GRCm39) T595A probably damaging Het
Col11a2 C T 17: 34,281,853 (GRCm39) probably benign Het
Col27a1 A G 4: 63,143,637 (GRCm39) T442A probably benign Het
Cpsf1 A G 15: 76,484,880 (GRCm39) probably null Het
Enpp4 T C 17: 44,413,066 (GRCm39) N156S probably benign Het
Fat3 T A 9: 15,874,162 (GRCm39) N3485I probably damaging Het
Gabra2 C T 5: 71,130,779 (GRCm39) V350I probably benign Het
H2-T5 G T 17: 36,473,084 (GRCm39) probably benign Het
Hivep2 A G 10: 14,004,493 (GRCm39) T364A probably damaging Het
Kif1b A T 4: 149,266,384 (GRCm39) V402E probably damaging Het
Lamc3 A G 2: 31,812,440 (GRCm39) D959G probably benign Het
Mag T A 7: 30,607,779 (GRCm39) probably benign Het
Map3k1 A G 13: 111,892,238 (GRCm39) F1006L probably benign Het
Mapre2 G A 18: 23,986,750 (GRCm39) G54D probably damaging Het
Muc6 G T 7: 141,218,685 (GRCm39) T1996N possibly damaging Het
Myadm C T 7: 3,346,080 (GRCm39) Q281* probably null Het
Mylk3 A T 8: 86,053,832 (GRCm39) V625D possibly damaging Het
Nlrp9a T C 7: 26,273,213 (GRCm39) probably benign Het
Or8d6 A G 9: 39,854,252 (GRCm39) D232G probably benign Het
Plcz1 T A 6: 139,986,290 (GRCm39) probably benign Het
Plekhg5 TCCCCC TCC 4: 152,197,108 (GRCm39) probably benign Het
Plekhh2 A C 17: 84,893,861 (GRCm39) D892A probably benign Het
Ppih A G 4: 119,175,798 (GRCm39) probably benign Het
Pramel13 G T 4: 144,122,423 (GRCm39) F40L probably damaging Het
Rtn4ip1 A T 10: 43,808,474 (GRCm39) M84L probably benign Het
Spocd1 G T 4: 129,850,571 (GRCm39) D866Y possibly damaging Het
Stxbp4 C T 11: 90,439,743 (GRCm39) R365Q possibly damaging Het
Tmed4 C T 11: 6,221,781 (GRCm39) R185H probably damaging Het
Tnfsf9 T C 17: 57,414,236 (GRCm39) V221A possibly damaging Het
Trappc14 T C 5: 138,260,916 (GRCm39) probably null Het
Vsx2 C A 12: 84,617,015 (GRCm39) P100Q possibly damaging Het
Wdr48 T A 9: 119,738,500 (GRCm39) D53E probably benign Het
Zfp335 T A 2: 164,751,222 (GRCm39) S115C possibly damaging Het
Zfp608 G A 18: 55,028,592 (GRCm39) P1274S possibly damaging Het
Other mutations in Slc35f4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01511:Slc35f4 APN 14 49,536,334 (GRCm39) missense probably benign 0.15
IGL01640:Slc35f4 APN 14 49,556,225 (GRCm39) missense probably damaging 0.99
IGL01942:Slc35f4 APN 14 49,762,962 (GRCm39) splice site probably benign
IGL01990:Slc35f4 APN 14 49,541,626 (GRCm39) critical splice donor site probably null
IGL02097:Slc35f4 APN 14 49,543,703 (GRCm39) missense probably damaging 1.00
IGL02803:Slc35f4 APN 14 49,541,714 (GRCm39) missense probably benign 0.00
R0238:Slc35f4 UTSW 14 49,541,713 (GRCm39) missense possibly damaging 0.78
R0238:Slc35f4 UTSW 14 49,541,713 (GRCm39) missense possibly damaging 0.78
R0239:Slc35f4 UTSW 14 49,541,713 (GRCm39) missense possibly damaging 0.78
R0239:Slc35f4 UTSW 14 49,541,713 (GRCm39) missense possibly damaging 0.78
R0764:Slc35f4 UTSW 14 49,543,796 (GRCm39) splice site probably benign
R1884:Slc35f4 UTSW 14 49,551,091 (GRCm39) missense probably damaging 1.00
R1916:Slc35f4 UTSW 14 49,541,380 (GRCm39) intron probably benign
R2047:Slc35f4 UTSW 14 49,541,029 (GRCm39) intron probably benign
R2239:Slc35f4 UTSW 14 49,543,660 (GRCm39) critical splice donor site probably null
R2380:Slc35f4 UTSW 14 49,543,660 (GRCm39) critical splice donor site probably null
R4273:Slc35f4 UTSW 14 49,541,758 (GRCm39) missense possibly damaging 0.81
R4420:Slc35f4 UTSW 14 49,551,034 (GRCm39) unclassified probably benign
R4425:Slc35f4 UTSW 14 49,556,307 (GRCm39) missense possibly damaging 0.85
R5261:Slc35f4 UTSW 14 49,540,946 (GRCm39) intron probably benign
R5398:Slc35f4 UTSW 14 49,536,304 (GRCm39) missense probably damaging 1.00
R5402:Slc35f4 UTSW 14 49,556,331 (GRCm39) missense probably damaging 1.00
R6310:Slc35f4 UTSW 14 49,559,914 (GRCm39) missense probably damaging 1.00
R6596:Slc35f4 UTSW 14 49,763,057 (GRCm39) missense probably damaging 1.00
R6729:Slc35f4 UTSW 14 49,556,417 (GRCm39) missense probably benign 0.16
R6864:Slc35f4 UTSW 14 49,556,310 (GRCm39) missense possibly damaging 0.55
R7427:Slc35f4 UTSW 14 49,536,355 (GRCm39) missense probably damaging 0.99
R7428:Slc35f4 UTSW 14 49,536,355 (GRCm39) missense probably damaging 0.99
R7559:Slc35f4 UTSW 14 49,541,732 (GRCm39) missense probably benign 0.03
R7596:Slc35f4 UTSW 14 49,543,666 (GRCm39) missense probably damaging 1.00
R7722:Slc35f4 UTSW 14 49,543,731 (GRCm39) missense probably benign 0.22
R8263:Slc35f4 UTSW 14 49,551,084 (GRCm39) missense probably damaging 1.00
R8525:Slc35f4 UTSW 14 49,541,681 (GRCm39) missense possibly damaging 0.56
R9198:Slc35f4 UTSW 14 49,556,377 (GRCm39) missense unknown
R9615:Slc35f4 UTSW 14 49,556,306 (GRCm39) missense probably benign 0.00
R9751:Slc35f4 UTSW 14 49,536,291 (GRCm39) missense possibly damaging 0.49
R9772:Slc35f4 UTSW 14 49,551,175 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTACTGAAGAGAAGGTCACCCAC -3'
(R):5'- GAAATGCAAGTTCCCGCCCAAG -3'

Sequencing Primer
(F):5'- GGTCACCCACATACCTGATCTG -3'
(R):5'- TCTATCAAAAGAGGCTCTAAGAGAC -3'
Posted On 2013-07-30