Incidental Mutation 'R8267:Or10g1b'
ID 639597
Institutional Source Beutler Lab
Gene Symbol Or10g1b
Ensembl Gene ENSMUSG00000063867
Gene Name olfactory receptor family 10 subfamily G member 1B
Synonyms Olfr1511, GA_x6K02T2RJGY-608749-609705, MOR223-9
MMRRC Submission 067651-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R8267 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52627272-52628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 52627903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 109 (F109S)
Ref Sequence ENSEMBL: ENSMUSP00000077302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078171]
AlphaFold E9PWU0
Predicted Effect probably damaging
Transcript: ENSMUST00000078171
AA Change: F109S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000077302
Gene: ENSMUSG00000063867
AA Change: F109S

DomainStartEndE-ValueType
Pfam:7tm_4 35 310 1.3e-50 PFAM
Pfam:7tm_1 45 293 2.5e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf2 CAT CATAAT 5: 24,781,589 (GRCm39) probably benign Het
Acbd3 A G 1: 180,574,413 (GRCm39) D379G probably damaging Het
Akp3 A T 1: 87,055,461 (GRCm39) T503S unknown Het
Antxr2 T A 5: 98,113,621 (GRCm39) probably null Het
Col9a1 A T 1: 24,224,267 (GRCm39) T150S unknown Het
Coro1c T C 5: 113,985,636 (GRCm39) D287G probably damaging Het
Cox16 T C 12: 81,527,713 (GRCm39) T45A probably benign Het
Cux1 A G 5: 136,311,853 (GRCm39) L1161P probably damaging Het
Dock10 T C 1: 80,518,045 (GRCm39) T1311A probably benign Het
Dop1a C T 9: 86,396,054 (GRCm39) P839S possibly damaging Het
Ehbp1 T A 11: 22,096,562 (GRCm39) D334V probably benign Het
H2-T15 A G 17: 36,367,675 (GRCm39) V221A possibly damaging Het
Hip1 A T 5: 135,457,467 (GRCm39) Y720N probably benign Het
Hmcn1 A G 1: 150,735,005 (GRCm39) F169S probably damaging Het
Hmcn2 A G 2: 31,349,191 (GRCm39) T4977A probably benign Het
Kcnq5 A T 1: 21,575,609 (GRCm39) I279N probably damaging Het
Lnx2 A T 5: 146,965,901 (GRCm39) I406N probably damaging Het
Mdn1 T C 4: 32,742,485 (GRCm39) Y3908H possibly damaging Het
Nme7 A G 1: 164,168,344 (GRCm39) I128V probably benign Het
Optn T C 2: 5,059,462 (GRCm39) T19A probably benign Het
Or4k37 A G 2: 111,159,160 (GRCm39) Y132C probably benign Het
Pmch A T 10: 87,926,979 (GRCm39) probably benign Het
Rbms3 T C 9: 116,885,823 (GRCm39) N141D possibly damaging Het
Reln A G 5: 22,209,110 (GRCm39) L1156P probably damaging Het
Rgs6 A C 12: 82,698,669 (GRCm39) M23L probably benign Het
Sh3tc1 T C 5: 35,863,751 (GRCm39) Y812C probably benign Het
Smap1 T A 1: 23,905,365 (GRCm39) K143I probably damaging Het
Thbs1 A T 2: 117,952,994 (GRCm39) H868L probably damaging Het
Tnip3 T G 6: 65,582,826 (GRCm39) V140G possibly damaging Het
Vmn2r100 T A 17: 19,742,752 (GRCm39) C375* probably null Het
Vmn2r19 T C 6: 123,313,221 (GRCm39) S764P possibly damaging Het
Vmn2r22 T C 6: 123,615,000 (GRCm39) T197A possibly damaging Het
Vmn2r59 T G 7: 41,661,521 (GRCm39) T765P probably damaging Het
Vmn2r71 A G 7: 85,264,704 (GRCm39) K12R probably benign Het
Vps41 T C 13: 18,994,641 (GRCm39) S163P probably benign Het
Wdr97 C T 15: 76,240,794 (GRCm39) A494V Het
Zfp382 G C 7: 29,833,929 (GRCm39) G527R probably damaging Het
Other mutations in Or10g1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02614:Or10g1b APN 14 52,627,627 (GRCm39) missense probably damaging 0.99
IGL02645:Or10g1b APN 14 52,627,958 (GRCm39) missense possibly damaging 0.50
R0277:Or10g1b UTSW 14 52,627,846 (GRCm39) missense probably damaging 1.00
R0601:Or10g1b UTSW 14 52,627,283 (GRCm39) nonsense probably null
R1956:Or10g1b UTSW 14 52,628,037 (GRCm39) missense probably benign 0.06
R2342:Or10g1b UTSW 14 52,627,322 (GRCm39) missense possibly damaging 0.89
R5193:Or10g1b UTSW 14 52,628,069 (GRCm39) missense probably benign 0.00
R5439:Or10g1b UTSW 14 52,627,582 (GRCm39) missense probably damaging 1.00
R5506:Or10g1b UTSW 14 52,628,084 (GRCm39) missense probably damaging 1.00
R6948:Or10g1b UTSW 14 52,627,614 (GRCm39) missense probably benign 0.22
R8191:Or10g1b UTSW 14 52,627,987 (GRCm39) missense probably benign 0.00
R8503:Or10g1b UTSW 14 52,627,354 (GRCm39) missense probably damaging 0.97
X0035:Or10g1b UTSW 14 52,627,823 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- TCGGAAGGTCAGAGTAGCTTG -3'
(R):5'- CATTTACATCCTGACACAGCTGG -3'

Sequencing Primer
(F):5'- TCAGAGTAGCTTGAATAGACCCATG -3'
(R):5'- ATCCTGACACAGCTGGGGAAC -3'
Posted On 2020-07-28