Incidental Mutation 'R8265:Zfp267'
| ID |
639664 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp267
|
| Ensembl Gene |
ENSMUSG00000033883 |
| Gene Name |
zinc finger protein 267 |
| Synonyms |
D3Ertd254e |
| MMRRC Submission |
067690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.128)
|
| Stock # |
R8265 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
36205233-36224491 bp(+) (GRCm39) |
| Type of Mutation |
start gained |
| DNA Base Change (assembly) |
T to C
at 36213677 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145477
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165956]
[ENSMUST00000197653]
[ENSMUST00000205077]
|
| AlphaFold |
A0A0G2JEM5 |
| Predicted Effect |
silent
Transcript: ENSMUST00000165956
|
| SMART Domains |
Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
63 |
2.91e-34 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
535 |
557 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
647 |
669 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
675 |
697 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
703 |
725 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
731 |
753 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
759 |
779 |
3.85e1 |
SMART |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000197653
|
| SMART Domains |
Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
1.2e-36 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
4.4e-4 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
6.7e-5 |
SMART |
|
ZnF_C2H2
|
424 |
446 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
452 |
474 |
2.5e-5 |
SMART |
|
ZnF_C2H2
|
480 |
502 |
7.9e-6 |
SMART |
|
ZnF_C2H2
|
508 |
530 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
536 |
558 |
7.7e-7 |
SMART |
|
ZnF_C2H2
|
564 |
586 |
8e-6 |
SMART |
|
ZnF_C2H2
|
592 |
614 |
8.9e-5 |
SMART |
|
ZnF_C2H2
|
620 |
642 |
6.6e-7 |
SMART |
|
ZnF_C2H2
|
648 |
670 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
676 |
698 |
7.1e-6 |
SMART |
|
ZnF_C2H2
|
704 |
726 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
732 |
754 |
4.8e-6 |
SMART |
|
ZnF_C2H2
|
760 |
780 |
1.6e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205077
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 45 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810055G02Rik |
A |
G |
19: 3,766,568 (GRCm39) |
T52A |
probably benign |
Het |
| Adam9 |
T |
C |
8: 25,457,202 (GRCm39) |
Y642C |
probably damaging |
Het |
| Atp2c1 |
T |
C |
9: 105,347,315 (GRCm39) |
E47G |
probably benign |
Het |
| Btbd9 |
T |
A |
17: 30,553,278 (GRCm39) |
T395S |
possibly damaging |
Het |
| Cacna1s |
G |
A |
1: 136,020,364 (GRCm39) |
W800* |
probably null |
Het |
| Cdr1 |
AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC |
AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC |
X: 60,228,130 (GRCm39) |
|
probably benign |
Het |
| Ceacam20 |
G |
A |
7: 19,708,159 (GRCm39) |
V255M |
probably damaging |
Het |
| Cit |
C |
A |
5: 116,126,236 (GRCm39) |
L1610M |
probably damaging |
Het |
| Cped1 |
A |
G |
6: 22,222,426 (GRCm39) |
T729A |
probably benign |
Het |
| Ddx19b |
A |
T |
8: 111,735,824 (GRCm39) |
V407E |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,217,603 (GRCm39) |
K1348E |
probably benign |
Het |
| E2f4 |
T |
A |
8: 106,027,977 (GRCm39) |
S302T |
probably damaging |
Het |
| Eif1 |
A |
G |
11: 100,211,299 (GRCm39) |
E31G |
probably benign |
Het |
| G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
| Herc1 |
C |
T |
9: 66,293,986 (GRCm39) |
Q443* |
probably null |
Het |
| Hmgxb3 |
A |
G |
18: 61,300,410 (GRCm39) |
V222A |
possibly damaging |
Het |
| Hnrnpu |
A |
T |
1: 178,159,725 (GRCm39) |
I452N |
unknown |
Het |
| Ints1 |
C |
G |
5: 139,757,919 (GRCm39) |
D260H |
probably damaging |
Het |
| Kdm5a |
T |
A |
6: 120,383,557 (GRCm39) |
M766K |
possibly damaging |
Het |
| Lama4 |
G |
A |
10: 38,981,200 (GRCm39) |
C1720Y |
probably damaging |
Het |
| Mei1 |
C |
A |
15: 81,987,508 (GRCm39) |
Y433* |
probably null |
Het |
| Milr1 |
A |
G |
11: 106,654,711 (GRCm39) |
K188E |
probably benign |
Het |
| Myo7a |
A |
G |
7: 97,734,604 (GRCm39) |
F630S |
probably benign |
Het |
| Myoz2 |
A |
G |
3: 122,800,172 (GRCm39) |
F219L |
probably benign |
Het |
| Nt5c1a |
T |
C |
4: 123,107,953 (GRCm39) |
V212A |
possibly damaging |
Het |
| Or51f1e |
A |
G |
7: 102,747,304 (GRCm39) |
T119A |
probably benign |
Het |
| Or51v14 |
A |
T |
7: 103,261,048 (GRCm39) |
C171S |
possibly damaging |
Het |
| Or8b42 |
T |
C |
9: 38,342,469 (GRCm39) |
V297A |
probably damaging |
Het |
| Pi16 |
A |
G |
17: 29,545,947 (GRCm39) |
T242A |
probably benign |
Het |
| Pigw |
C |
A |
11: 84,770,847 (GRCm39) |
|
probably benign |
Het |
| Pipox |
T |
A |
11: 77,774,793 (GRCm39) |
T97S |
probably benign |
Het |
| Plagl1 |
C |
A |
10: 13,004,625 (GRCm39) |
A631E |
unknown |
Het |
| Poteg |
T |
A |
8: 27,984,923 (GRCm39) |
H427Q |
possibly damaging |
Het |
| Prdm14 |
A |
G |
1: 13,184,618 (GRCm39) |
S518P |
probably damaging |
Het |
| Rabep2 |
A |
G |
7: 126,043,423 (GRCm39) |
E441G |
probably benign |
Het |
| Rasal3 |
A |
G |
17: 32,614,794 (GRCm39) |
|
probably null |
Het |
| Rbm33 |
T |
C |
5: 28,599,322 (GRCm39) |
V90A |
|
Het |
| Sidt1 |
C |
A |
16: 44,088,250 (GRCm39) |
R381M |
possibly damaging |
Het |
| Sppl2b |
TGTCACAGGT |
TGT |
10: 80,701,903 (GRCm39) |
|
probably null |
Het |
| Srsf5 |
A |
G |
12: 80,994,110 (GRCm39) |
D51G |
possibly damaging |
Het |
| Taar8a |
T |
A |
10: 23,952,839 (GRCm39) |
S148T |
probably damaging |
Het |
| Tmem59l |
A |
G |
8: 70,938,426 (GRCm39) |
S149P |
probably damaging |
Het |
| Trafd1 |
T |
A |
5: 121,511,340 (GRCm39) |
I493F |
possibly damaging |
Het |
| Trrap |
C |
T |
5: 144,722,344 (GRCm39) |
S289L |
possibly damaging |
Het |
| Zfp955a |
C |
T |
17: 33,463,087 (GRCm39) |
V15M |
probably damaging |
Het |
|
| Other mutations in Zfp267 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01524:Zfp267
|
APN |
3 |
36,218,729 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02089:Zfp267
|
APN |
3 |
36,218,877 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02162:Zfp267
|
APN |
3 |
36,218,210 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0243:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0512:Zfp267
|
UTSW |
3 |
36,220,262 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0722:Zfp267
|
UTSW |
3 |
36,219,218 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0762:Zfp267
|
UTSW |
3 |
36,220,016 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0792:Zfp267
|
UTSW |
3 |
36,218,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0894:Zfp267
|
UTSW |
3 |
36,218,935 (GRCm39) |
nonsense |
probably null |
|
|
R1731:Zfp267
|
UTSW |
3 |
36,218,620 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2098:Zfp267
|
UTSW |
3 |
36,220,289 (GRCm39) |
missense |
probably benign |
|
|
R2099:Zfp267
|
UTSW |
3 |
36,218,361 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3709:Zfp267
|
UTSW |
3 |
36,213,725 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3808:Zfp267
|
UTSW |
3 |
36,219,792 (GRCm39) |
splice site |
probably null |
|
|
R4035:Zfp267
|
UTSW |
3 |
36,218,989 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4288:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4289:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4959:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4973:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5102:Zfp267
|
UTSW |
3 |
36,216,814 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5462:Zfp267
|
UTSW |
3 |
36,219,969 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5548:Zfp267
|
UTSW |
3 |
36,219,640 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5782:Zfp267
|
UTSW |
3 |
36,219,128 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6153:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6225:Zfp267
|
UTSW |
3 |
36,220,352 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6602:Zfp267
|
UTSW |
3 |
36,219,004 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6785:Zfp267
|
UTSW |
3 |
36,219,601 (GRCm39) |
nonsense |
probably null |
|
|
R7513:Zfp267
|
UTSW |
3 |
36,218,792 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7846:Zfp267
|
UTSW |
3 |
36,219,738 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8120:Zfp267
|
UTSW |
3 |
36,218,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8415:Zfp267
|
UTSW |
3 |
36,219,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8826:Zfp267
|
UTSW |
3 |
36,218,255 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9026:Zfp267
|
UTSW |
3 |
36,219,066 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9159:Zfp267
|
UTSW |
3 |
36,219,902 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9786:Zfp267
|
UTSW |
3 |
36,219,853 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Zfp267
|
UTSW |
3 |
36,218,340 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATCTTTACTCAGGGGCTAGGTAATAC -3'
(R):5'- TAATAGTGCCACTCCTGGGC -3'
Sequencing Primer
(F):5'- TACTCAGGGGCTAGGTAATACATTAG -3'
(R):5'- ACTCCTGGGCCGAGCATATAC -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation