Incidental Mutation 'R8265:Cped1'
ID 639672
Institutional Source Beutler Lab
Gene Symbol Cped1
Ensembl Gene ENSMUSG00000062980
Gene Name cadherin-like and PC-esterase domain containing 1
Synonyms A430107O13Rik
MMRRC Submission 067690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R8265 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 21985915-22256403 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 22222426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 729 (T729A)
Ref Sequence ENSEMBL: ENSMUSP00000111041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115383]
AlphaFold B2RX70
Predicted Effect probably benign
Transcript: ENSMUST00000115383
AA Change: T729A

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000111041
Gene: ENSMUSG00000062980
AA Change: T729A

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 110 122 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
Pfam:Cadherin-like 574 663 1e-9 PFAM
Pfam:PC-Esterase 753 1018 2e-26 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000119808
Gene: ENSMUSG00000062980
AA Change: T591A

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 110 122 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
Pfam:Cadherin-like 570 663 6.2e-12 PFAM
Pfam:PC-Esterase 753 963 1.6e-33 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik A G 19: 3,766,568 (GRCm39) T52A probably benign Het
Adam9 T C 8: 25,457,202 (GRCm39) Y642C probably damaging Het
Atp2c1 T C 9: 105,347,315 (GRCm39) E47G probably benign Het
Btbd9 T A 17: 30,553,278 (GRCm39) T395S possibly damaging Het
Cacna1s G A 1: 136,020,364 (GRCm39) W800* probably null Het
Cdr1 AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC X: 60,228,130 (GRCm39) probably benign Het
Ceacam20 G A 7: 19,708,159 (GRCm39) V255M probably damaging Het
Cit C A 5: 116,126,236 (GRCm39) L1610M probably damaging Het
Ddx19b A T 8: 111,735,824 (GRCm39) V407E probably damaging Het
Dst A G 1: 34,217,603 (GRCm39) K1348E probably benign Het
E2f4 T A 8: 106,027,977 (GRCm39) S302T probably damaging Het
Eif1 A G 11: 100,211,299 (GRCm39) E31G probably benign Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Herc1 C T 9: 66,293,986 (GRCm39) Q443* probably null Het
Hmgxb3 A G 18: 61,300,410 (GRCm39) V222A possibly damaging Het
Hnrnpu A T 1: 178,159,725 (GRCm39) I452N unknown Het
Ints1 C G 5: 139,757,919 (GRCm39) D260H probably damaging Het
Kdm5a T A 6: 120,383,557 (GRCm39) M766K possibly damaging Het
Lama4 G A 10: 38,981,200 (GRCm39) C1720Y probably damaging Het
Mei1 C A 15: 81,987,508 (GRCm39) Y433* probably null Het
Milr1 A G 11: 106,654,711 (GRCm39) K188E probably benign Het
Myo7a A G 7: 97,734,604 (GRCm39) F630S probably benign Het
Myoz2 A G 3: 122,800,172 (GRCm39) F219L probably benign Het
Nt5c1a T C 4: 123,107,953 (GRCm39) V212A possibly damaging Het
Or51f1e A G 7: 102,747,304 (GRCm39) T119A probably benign Het
Or51v14 A T 7: 103,261,048 (GRCm39) C171S possibly damaging Het
Or8b42 T C 9: 38,342,469 (GRCm39) V297A probably damaging Het
Pi16 A G 17: 29,545,947 (GRCm39) T242A probably benign Het
Pigw C A 11: 84,770,847 (GRCm39) probably benign Het
Pipox T A 11: 77,774,793 (GRCm39) T97S probably benign Het
Plagl1 C A 10: 13,004,625 (GRCm39) A631E unknown Het
Poteg T A 8: 27,984,923 (GRCm39) H427Q possibly damaging Het
Prdm14 A G 1: 13,184,618 (GRCm39) S518P probably damaging Het
Rabep2 A G 7: 126,043,423 (GRCm39) E441G probably benign Het
Rasal3 A G 17: 32,614,794 (GRCm39) probably null Het
Rbm33 T C 5: 28,599,322 (GRCm39) V90A Het
Sidt1 C A 16: 44,088,250 (GRCm39) R381M possibly damaging Het
Sppl2b TGTCACAGGT TGT 10: 80,701,903 (GRCm39) probably null Het
Srsf5 A G 12: 80,994,110 (GRCm39) D51G possibly damaging Het
Taar8a T A 10: 23,952,839 (GRCm39) S148T probably damaging Het
Tmem59l A G 8: 70,938,426 (GRCm39) S149P probably damaging Het
Trafd1 T A 5: 121,511,340 (GRCm39) I493F possibly damaging Het
Trrap C T 5: 144,722,344 (GRCm39) S289L possibly damaging Het
Zfp267 T C 3: 36,213,677 (GRCm39) probably benign Het
Zfp955a C T 17: 33,463,087 (GRCm39) V15M probably damaging Het
Other mutations in Cped1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Cped1 APN 6 22,215,522 (GRCm39) missense probably damaging 1.00
IGL00909:Cped1 APN 6 22,122,426 (GRCm39) splice site probably benign
IGL01434:Cped1 APN 6 22,017,004 (GRCm39) missense probably damaging 0.99
IGL01572:Cped1 APN 6 22,051,300 (GRCm39) missense probably benign 0.00
IGL02063:Cped1 APN 6 22,138,701 (GRCm39) missense probably damaging 0.98
IGL02216:Cped1 APN 6 22,059,944 (GRCm39) missense probably damaging 1.00
IGL02257:Cped1 APN 6 22,145,606 (GRCm39) missense possibly damaging 0.86
IGL02541:Cped1 APN 6 22,120,988 (GRCm39) missense probably benign 0.00
IGL03008:Cped1 APN 6 22,233,601 (GRCm39) missense probably benign 0.01
IGL03237:Cped1 APN 6 22,233,595 (GRCm39) missense probably damaging 1.00
PIT4382001:Cped1 UTSW 6 22,222,449 (GRCm39) nonsense probably null
PIT4812001:Cped1 UTSW 6 22,122,293 (GRCm39) missense probably benign 0.02
R0048:Cped1 UTSW 6 22,119,601 (GRCm39) missense probably benign 0.08
R0128:Cped1 UTSW 6 22,121,038 (GRCm39) missense probably benign 0.00
R0130:Cped1 UTSW 6 22,121,038 (GRCm39) missense probably benign 0.00
R0267:Cped1 UTSW 6 22,119,475 (GRCm39) missense probably damaging 0.99
R0374:Cped1 UTSW 6 22,222,545 (GRCm39) splice site probably benign
R0482:Cped1 UTSW 6 22,016,957 (GRCm39) missense probably benign 0.32
R0734:Cped1 UTSW 6 22,085,040 (GRCm39) missense probably damaging 1.00
R1033:Cped1 UTSW 6 22,016,950 (GRCm39) missense probably damaging 0.99
R1118:Cped1 UTSW 6 22,237,698 (GRCm39) missense probably benign 0.19
R1181:Cped1 UTSW 6 22,215,561 (GRCm39) missense probably damaging 0.99
R1300:Cped1 UTSW 6 22,119,552 (GRCm39) missense probably benign 0.00
R1485:Cped1 UTSW 6 22,132,387 (GRCm39) critical splice donor site probably null
R1507:Cped1 UTSW 6 22,122,260 (GRCm39) missense probably damaging 1.00
R1830:Cped1 UTSW 6 22,237,727 (GRCm39) missense probably damaging 1.00
R1879:Cped1 UTSW 6 22,085,014 (GRCm39) splice site probably null
R1902:Cped1 UTSW 6 22,120,980 (GRCm39) splice site probably null
R1991:Cped1 UTSW 6 22,233,926 (GRCm39) missense probably damaging 1.00
R2020:Cped1 UTSW 6 22,143,963 (GRCm39) missense probably benign 0.38
R2883:Cped1 UTSW 6 22,143,978 (GRCm39) missense probably damaging 1.00
R3011:Cped1 UTSW 6 22,088,695 (GRCm39) missense probably damaging 1.00
R4466:Cped1 UTSW 6 22,123,651 (GRCm39) missense probably benign 0.29
R4668:Cped1 UTSW 6 22,237,652 (GRCm39) missense probably benign 0.06
R4808:Cped1 UTSW 6 22,088,756 (GRCm39) missense probably damaging 1.00
R5402:Cped1 UTSW 6 22,143,951 (GRCm39) missense probably benign 0.05
R5417:Cped1 UTSW 6 22,233,579 (GRCm39) missense probably null 0.01
R5741:Cped1 UTSW 6 22,123,620 (GRCm39) missense probably benign 0.02
R5821:Cped1 UTSW 6 22,138,681 (GRCm39) missense probably benign 0.00
R5977:Cped1 UTSW 6 22,254,607 (GRCm39) missense probably damaging 1.00
R6255:Cped1 UTSW 6 22,138,714 (GRCm39) splice site probably null
R6304:Cped1 UTSW 6 22,016,922 (GRCm39) missense probably benign 0.14
R6416:Cped1 UTSW 6 22,123,648 (GRCm39) missense probably damaging 1.00
R6444:Cped1 UTSW 6 21,986,930 (GRCm39) missense probably benign 0.00
R6617:Cped1 UTSW 6 22,215,546 (GRCm39) nonsense probably null
R6650:Cped1 UTSW 6 22,233,975 (GRCm39) missense probably damaging 1.00
R7048:Cped1 UTSW 6 22,119,469 (GRCm39) missense probably benign 0.36
R7083:Cped1 UTSW 6 22,123,579 (GRCm39) missense probably benign 0.01
R7234:Cped1 UTSW 6 22,254,625 (GRCm39) missense probably damaging 0.99
R7387:Cped1 UTSW 6 22,059,933 (GRCm39) missense probably benign 0.01
R7493:Cped1 UTSW 6 22,215,512 (GRCm39) missense probably damaging 1.00
R7720:Cped1 UTSW 6 22,222,430 (GRCm39) missense probably damaging 1.00
R7747:Cped1 UTSW 6 22,143,973 (GRCm39) missense probably damaging 1.00
R7966:Cped1 UTSW 6 22,059,953 (GRCm39) critical splice donor site probably null
R8113:Cped1 UTSW 6 22,233,480 (GRCm39) missense possibly damaging 0.89
R8186:Cped1 UTSW 6 22,123,587 (GRCm39) missense probably benign 0.01
R8215:Cped1 UTSW 6 22,132,277 (GRCm39) missense probably damaging 1.00
R8280:Cped1 UTSW 6 21,986,820 (GRCm39) missense unknown
R8286:Cped1 UTSW 6 22,254,601 (GRCm39) missense probably benign 0.03
R8393:Cped1 UTSW 6 22,222,465 (GRCm39) missense possibly damaging 0.80
R8503:Cped1 UTSW 6 22,145,564 (GRCm39) missense probably benign 0.02
R8725:Cped1 UTSW 6 22,059,941 (GRCm39) missense possibly damaging 0.71
R8727:Cped1 UTSW 6 22,059,941 (GRCm39) missense possibly damaging 0.71
R8852:Cped1 UTSW 6 22,215,620 (GRCm39) missense probably damaging 1.00
R8881:Cped1 UTSW 6 22,119,578 (GRCm39) missense possibly damaging 0.58
R8888:Cped1 UTSW 6 22,016,962 (GRCm39) missense possibly damaging 0.51
R8983:Cped1 UTSW 6 22,138,686 (GRCm39) missense probably benign 0.00
R9135:Cped1 UTSW 6 21,987,012 (GRCm39) missense probably damaging 0.98
X0022:Cped1 UTSW 6 21,987,045 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TCTGCTTGACTCACAGGAGG -3'
(R):5'- GAGTTAGTTTTCCTCACTGCAAGAG -3'

Sequencing Primer
(F):5'- GGCCCTGCCTTTTCCCAC -3'
(R):5'- TAGCACATGCAATGGTCTGGC -3'
Posted On 2020-07-28