Incidental Mutation 'R8263:Casp8ap2'
| ID |
639765 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Casp8ap2
|
| Ensembl Gene |
ENSMUSG00000028282 |
| Gene Name |
caspase 8 associated protein 2 |
| Synonyms |
FLASH, D4Ertd659e |
| MMRRC Submission |
067688-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8263 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
32615462-32653271 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 32644072 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 1048
(H1048Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000029950
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029950]
[ENSMUST00000108178]
[ENSMUST00000178925]
|
| AlphaFold |
Q9WUF3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000029950
AA Change: H1048Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000029950
Gene: ENSMUSG00000028282
AA Change: H1048Q
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
|
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
|
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
|
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108178
|
| SMART Domains |
Protein: ENSMUSP00000103813
Gene: ENSMUSG00000028282
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2LR8|A
|
126 |
190 |
4e-26 |
PDB |
|
Blast:SANT
|
139 |
183 |
4e-19 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000178925
AA Change: H1048Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000136016
Gene: ENSMUSG00000028282
AA Change: H1048Q
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
|
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
|
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
|
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
PHENOTYPE: Mice homozygous for disruption of this gene die before implantation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630095N17Rik |
T |
A |
1: 75,208,683 (GRCm39) |
R12S |
unknown |
Het |
| Ankrd10 |
C |
T |
8: 11,665,707 (GRCm39) |
V298I |
probably benign |
Het |
| Atg4d |
T |
A |
9: 21,178,335 (GRCm39) |
M151K |
probably damaging |
Het |
| Calhm5 |
C |
A |
10: 33,972,192 (GRCm39) |
C81F |
probably damaging |
Het |
| Cd300ld2 |
A |
G |
11: 114,903,192 (GRCm39) |
S218P |
unknown |
Het |
| Clec3a |
T |
C |
8: 115,152,369 (GRCm39) |
V125A |
probably benign |
Het |
| Cnot6 |
A |
T |
11: 49,573,002 (GRCm39) |
Y241N |
probably damaging |
Het |
| Dnah1 |
A |
T |
14: 31,015,134 (GRCm39) |
F1686Y |
probably damaging |
Het |
| Dnah12 |
A |
G |
14: 26,613,421 (GRCm39) |
K1285E |
noncoding transcript |
Het |
| Dop1b |
T |
C |
16: 93,559,083 (GRCm39) |
S610P |
possibly damaging |
Het |
| Ehhadh |
A |
T |
16: 21,592,295 (GRCm39) |
L136H |
probably damaging |
Het |
| Epha7 |
A |
G |
4: 28,821,149 (GRCm39) |
T105A |
probably damaging |
Het |
| Etl4 |
A |
T |
2: 20,748,965 (GRCm39) |
E434D |
probably benign |
Het |
| Fastkd2 |
T |
C |
1: 63,770,968 (GRCm39) |
V108A |
probably benign |
Het |
| Fat2 |
G |
A |
11: 55,174,962 (GRCm39) |
T1917I |
probably benign |
Het |
| Fbxo45 |
A |
G |
16: 32,065,533 (GRCm39) |
S33P |
unknown |
Het |
| Fig4 |
A |
T |
10: 41,143,711 (GRCm39) |
Y249* |
probably null |
Het |
| Fryl |
T |
C |
5: 73,238,348 (GRCm39) |
Y1466C |
probably damaging |
Het |
| G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
| Glod4 |
T |
C |
11: 76,125,318 (GRCm39) |
D147G |
possibly damaging |
Het |
| Gm12695 |
T |
G |
4: 96,651,046 (GRCm39) |
M136L |
probably benign |
Het |
| Gm5422 |
A |
G |
10: 31,125,099 (GRCm39) |
T313A |
noncoding transcript |
Het |
| Hydin |
C |
A |
8: 111,178,705 (GRCm39) |
A1100D |
probably benign |
Het |
| Ift172 |
G |
A |
5: 31,422,681 (GRCm39) |
A923V |
possibly damaging |
Het |
| Irgc |
G |
A |
7: 24,132,107 (GRCm39) |
H237Y |
probably damaging |
Het |
| Itga11 |
T |
C |
9: 62,604,262 (GRCm39) |
I50T |
possibly damaging |
Het |
| Itpr3 |
C |
T |
17: 27,334,887 (GRCm39) |
Q2134* |
probably null |
Het |
| Kat8 |
A |
T |
7: 127,523,653 (GRCm39) |
D292V |
possibly damaging |
Het |
| Kdm2a |
A |
G |
19: 4,374,392 (GRCm39) |
M913T |
possibly damaging |
Het |
| Larp4 |
T |
C |
15: 99,883,961 (GRCm39) |
V66A |
probably benign |
Het |
| Loxhd1 |
A |
G |
18: 77,462,858 (GRCm39) |
D899G |
probably damaging |
Het |
| Lrrc47 |
G |
T |
4: 154,100,486 (GRCm39) |
R354L |
probably damaging |
Het |
| Lss |
C |
T |
10: 76,367,739 (GRCm39) |
R24C |
probably damaging |
Het |
| Mmp14 |
C |
T |
14: 54,673,244 (GRCm39) |
R51C |
probably damaging |
Het |
| Mon1a |
C |
T |
9: 107,775,993 (GRCm39) |
T37I |
probably benign |
Het |
| Mtcl2 |
A |
G |
2: 156,869,510 (GRCm39) |
W1042R |
possibly damaging |
Het |
| Nacc2 |
A |
C |
2: 25,952,240 (GRCm39) |
V372G |
probably damaging |
Het |
| Ncapg |
T |
C |
5: 45,849,134 (GRCm39) |
V690A |
probably benign |
Het |
| Nhej1 |
A |
G |
1: 75,006,896 (GRCm39) |
L152P |
probably damaging |
Het |
| Nol4l |
A |
T |
2: 153,259,337 (GRCm39) |
S522R |
probably damaging |
Het |
| Nr0b2 |
A |
G |
4: 133,281,241 (GRCm39) |
Y169C |
probably damaging |
Het |
| Numa1 |
A |
G |
7: 101,648,491 (GRCm39) |
M741V |
probably benign |
Het |
| Or10d1b |
A |
G |
9: 39,613,453 (GRCm39) |
M204T |
possibly damaging |
Het |
| Or8g28 |
A |
G |
9: 39,169,899 (GRCm39) |
L26P |
probably damaging |
Het |
| Pebp1 |
C |
A |
5: 117,425,473 (GRCm39) |
|
probably null |
Het |
| Pik3ip1 |
A |
T |
11: 3,291,581 (GRCm39) |
I217F |
probably damaging |
Het |
| Plekhg1 |
T |
A |
10: 3,907,651 (GRCm39) |
I911N |
|
Het |
| Pnpla8 |
T |
C |
12: 44,342,846 (GRCm39) |
I534T |
probably damaging |
Het |
| Ppp2r2a |
A |
T |
14: 67,261,205 (GRCm39) |
F172I |
probably damaging |
Het |
| Rab7 |
C |
T |
6: 87,989,292 (GRCm39) |
M59I |
probably benign |
Het |
| Rbm34 |
T |
C |
8: 127,692,139 (GRCm39) |
N201S |
probably benign |
Het |
| Rfx1 |
G |
T |
8: 84,821,483 (GRCm39) |
R764L |
probably damaging |
Het |
| Rnase12 |
T |
A |
14: 51,294,580 (GRCm39) |
D33V |
probably damaging |
Het |
| Rnf121 |
A |
G |
7: 101,684,532 (GRCm39) |
L127P |
probably damaging |
Het |
| Rtl1 |
C |
A |
12: 109,560,180 (GRCm39) |
R553L |
probably damaging |
Het |
| Scn8a |
T |
C |
15: 100,881,736 (GRCm39) |
L601P |
probably damaging |
Het |
| Scyl2 |
G |
T |
10: 89,476,525 (GRCm39) |
Q867K |
possibly damaging |
Het |
| Sgtb |
T |
C |
13: 104,268,692 (GRCm39) |
F213L |
probably benign |
Het |
| Slc35f4 |
A |
G |
14: 49,551,084 (GRCm39) |
V260A |
probably damaging |
Het |
| Slfn14 |
A |
G |
11: 83,174,299 (GRCm39) |
Y231H |
possibly damaging |
Het |
| Sppl2b |
TGTCACAGGT |
TGT |
10: 80,701,903 (GRCm39) |
|
probably null |
Het |
| Stard13 |
G |
A |
5: 151,157,106 (GRCm39) |
A25V |
possibly damaging |
Het |
| Stk38 |
C |
T |
17: 29,203,161 (GRCm39) |
R135H |
probably damaging |
Het |
| Svil |
A |
G |
18: 5,108,679 (GRCm39) |
D1939G |
probably damaging |
Het |
| Tasor2 |
C |
T |
13: 3,625,286 (GRCm39) |
V1555I |
possibly damaging |
Het |
| Tasor2 |
G |
T |
13: 3,640,016 (GRCm39) |
P374T |
probably benign |
Het |
| Tbc1d7 |
A |
G |
13: 43,323,340 (GRCm39) |
V17A |
possibly damaging |
Het |
| Trpc4 |
T |
C |
3: 54,129,756 (GRCm39) |
V174A |
probably damaging |
Het |
| Ttn |
G |
T |
2: 76,619,028 (GRCm39) |
T16117K |
probably damaging |
Het |
| Tubb3 |
T |
A |
8: 124,147,868 (GRCm39) |
M267K |
possibly damaging |
Het |
| Upk1b |
T |
C |
16: 38,604,585 (GRCm39) |
T147A |
probably damaging |
Het |
| Vmn2r107 |
G |
T |
17: 20,580,614 (GRCm39) |
C517F |
probably damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,824,140 (GRCm39) |
D465G |
probably damaging |
Het |
| Vmn2r73 |
A |
T |
7: 85,507,619 (GRCm39) |
H564Q |
probably benign |
Het |
| Vmn2r79 |
A |
G |
7: 86,686,726 (GRCm39) |
I702M |
possibly damaging |
Het |
| Vmn2r84 |
A |
G |
10: 130,227,037 (GRCm39) |
V267A |
probably damaging |
Het |
| Zfp445 |
T |
C |
9: 122,681,878 (GRCm39) |
I688V |
probably benign |
Het |
| Zfp955a |
C |
T |
17: 33,463,087 (GRCm39) |
V15M |
probably damaging |
Het |
| Zfp960 |
T |
A |
17: 17,308,202 (GRCm39) |
C305* |
probably null |
Het |
| Zfp964 |
A |
G |
8: 70,116,345 (GRCm39) |
D315G |
possibly damaging |
Het |
| Zmynd10 |
T |
A |
9: 107,426,516 (GRCm39) |
I183K |
possibly damaging |
Het |
|
| Other mutations in Casp8ap2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00686:Casp8ap2
|
APN |
4 |
32,641,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00714:Casp8ap2
|
APN |
4 |
32,649,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Casp8ap2
|
APN |
4 |
32,641,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00954:Casp8ap2
|
APN |
4 |
32,645,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00970:Casp8ap2
|
APN |
4 |
32,646,182 (GRCm39) |
missense |
probably benign |
|
|
IGL01534:Casp8ap2
|
APN |
4 |
32,648,134 (GRCm39) |
splice site |
probably benign |
|
|
IGL01596:Casp8ap2
|
APN |
4 |
32,646,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01686:Casp8ap2
|
APN |
4 |
32,641,294 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02002:Casp8ap2
|
APN |
4 |
32,639,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02273:Casp8ap2
|
APN |
4 |
32,643,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02510:Casp8ap2
|
APN |
4 |
32,639,704 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02600:Casp8ap2
|
APN |
4 |
32,630,246 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL02929:Casp8ap2
|
APN |
4 |
32,624,105 (GRCm39) |
utr 5 prime |
probably benign |
|
|
F5770:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02988:Casp8ap2
|
UTSW |
4 |
32,644,590 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0023:Casp8ap2
|
UTSW |
4 |
32,640,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0027:Casp8ap2
|
UTSW |
4 |
32,643,810 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0090:Casp8ap2
|
UTSW |
4 |
32,640,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0117:Casp8ap2
|
UTSW |
4 |
32,640,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0144:Casp8ap2
|
UTSW |
4 |
32,643,797 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0268:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0344:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0555:Casp8ap2
|
UTSW |
4 |
32,640,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1051:Casp8ap2
|
UTSW |
4 |
32,640,790 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1165:Casp8ap2
|
UTSW |
4 |
32,640,563 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1243:Casp8ap2
|
UTSW |
4 |
32,645,687 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1311:Casp8ap2
|
UTSW |
4 |
32,648,111 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1337:Casp8ap2
|
UTSW |
4 |
32,645,721 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1471:Casp8ap2
|
UTSW |
4 |
32,639,386 (GRCm39) |
nonsense |
probably null |
|
|
R1497:Casp8ap2
|
UTSW |
4 |
32,639,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1521:Casp8ap2
|
UTSW |
4 |
32,631,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Casp8ap2
|
UTSW |
4 |
32,640,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1625:Casp8ap2
|
UTSW |
4 |
32,648,068 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1731:Casp8ap2
|
UTSW |
4 |
32,641,442 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1899:Casp8ap2
|
UTSW |
4 |
32,643,647 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2000:Casp8ap2
|
UTSW |
4 |
32,634,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2022:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2023:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2088:Casp8ap2
|
UTSW |
4 |
32,631,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2104:Casp8ap2
|
UTSW |
4 |
32,644,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2128:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2129:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2305:Casp8ap2
|
UTSW |
4 |
32,646,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2316:Casp8ap2
|
UTSW |
4 |
32,643,781 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2919:Casp8ap2
|
UTSW |
4 |
32,645,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Casp8ap2
|
UTSW |
4 |
32,643,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4357:Casp8ap2
|
UTSW |
4 |
32,646,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4807:Casp8ap2
|
UTSW |
4 |
32,644,505 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4828:Casp8ap2
|
UTSW |
4 |
32,639,807 (GRCm39) |
missense |
probably benign |
|
|
R4908:Casp8ap2
|
UTSW |
4 |
32,639,905 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4945:Casp8ap2
|
UTSW |
4 |
32,631,163 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4962:Casp8ap2
|
UTSW |
4 |
32,640,554 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6014:Casp8ap2
|
UTSW |
4 |
32,641,400 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6092:Casp8ap2
|
UTSW |
4 |
32,639,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6257:Casp8ap2
|
UTSW |
4 |
32,641,364 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6289:Casp8ap2
|
UTSW |
4 |
32,639,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6482:Casp8ap2
|
UTSW |
4 |
32,634,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6496:Casp8ap2
|
UTSW |
4 |
32,641,553 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6515:Casp8ap2
|
UTSW |
4 |
32,646,423 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7015:Casp8ap2
|
UTSW |
4 |
32,644,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Casp8ap2
|
UTSW |
4 |
32,639,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Casp8ap2
|
UTSW |
4 |
32,644,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Casp8ap2
|
UTSW |
4 |
32,643,974 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7944:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7945:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8170:Casp8ap2
|
UTSW |
4 |
32,615,490 (GRCm39) |
splice site |
probably benign |
|
|
R8179:Casp8ap2
|
UTSW |
4 |
32,643,939 (GRCm39) |
nonsense |
probably null |
|
|
R8207:Casp8ap2
|
UTSW |
4 |
32,646,446 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8298:Casp8ap2
|
UTSW |
4 |
32,640,429 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9441:Casp8ap2
|
UTSW |
4 |
32,645,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9455:Casp8ap2
|
UTSW |
4 |
32,643,924 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9729:Casp8ap2
|
UTSW |
4 |
32,643,807 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
V7580:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0018:Casp8ap2
|
UTSW |
4 |
32,643,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCTGTAAAACTCCCTCGG -3'
(R):5'- GTTGCTGTTCAAATAAACGGTCAAC -3'
Sequencing Primer
(F):5'- TGTAAAACTCCCTCGGGACAG -3'
(R):5'- AAACGGTCAACTATGCCATTCTTC -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation