Incidental Mutation 'R8263:Vmn2r73'
ID |
639776 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r73
|
Ensembl Gene |
ENSMUSG00000070458 |
Gene Name |
vomeronasal 2, receptor 73 |
Synonyms |
EG620928 |
MMRRC Submission |
067688-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.141)
|
Stock # |
R8263 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 85507619 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Glutamine
at position 564
(H564Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
AlphaFold |
D3Z7M3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000077478
AA Change: H564Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000076687 Gene: ENSMUSG00000070458 AA Change: H564Q
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 81 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A630095N17Rik |
T |
A |
1: 75,208,683 (GRCm39) |
R12S |
unknown |
Het |
Ankrd10 |
C |
T |
8: 11,665,707 (GRCm39) |
V298I |
probably benign |
Het |
Atg4d |
T |
A |
9: 21,178,335 (GRCm39) |
M151K |
probably damaging |
Het |
Calhm5 |
C |
A |
10: 33,972,192 (GRCm39) |
C81F |
probably damaging |
Het |
Casp8ap2 |
T |
A |
4: 32,644,072 (GRCm39) |
H1048Q |
probably damaging |
Het |
Cd300ld2 |
A |
G |
11: 114,903,192 (GRCm39) |
S218P |
unknown |
Het |
Clec3a |
T |
C |
8: 115,152,369 (GRCm39) |
V125A |
probably benign |
Het |
Cnot6 |
A |
T |
11: 49,573,002 (GRCm39) |
Y241N |
probably damaging |
Het |
Dnah1 |
A |
T |
14: 31,015,134 (GRCm39) |
F1686Y |
probably damaging |
Het |
Dnah12 |
A |
G |
14: 26,613,421 (GRCm39) |
K1285E |
noncoding transcript |
Het |
Dop1b |
T |
C |
16: 93,559,083 (GRCm39) |
S610P |
possibly damaging |
Het |
Ehhadh |
A |
T |
16: 21,592,295 (GRCm39) |
L136H |
probably damaging |
Het |
Epha7 |
A |
G |
4: 28,821,149 (GRCm39) |
T105A |
probably damaging |
Het |
Etl4 |
A |
T |
2: 20,748,965 (GRCm39) |
E434D |
probably benign |
Het |
Fastkd2 |
T |
C |
1: 63,770,968 (GRCm39) |
V108A |
probably benign |
Het |
Fat2 |
G |
A |
11: 55,174,962 (GRCm39) |
T1917I |
probably benign |
Het |
Fbxo45 |
A |
G |
16: 32,065,533 (GRCm39) |
S33P |
unknown |
Het |
Fig4 |
A |
T |
10: 41,143,711 (GRCm39) |
Y249* |
probably null |
Het |
Fryl |
T |
C |
5: 73,238,348 (GRCm39) |
Y1466C |
probably damaging |
Het |
G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
Glod4 |
T |
C |
11: 76,125,318 (GRCm39) |
D147G |
possibly damaging |
Het |
Gm12695 |
T |
G |
4: 96,651,046 (GRCm39) |
M136L |
probably benign |
Het |
Gm5422 |
A |
G |
10: 31,125,099 (GRCm39) |
T313A |
noncoding transcript |
Het |
Hydin |
C |
A |
8: 111,178,705 (GRCm39) |
A1100D |
probably benign |
Het |
Ift172 |
G |
A |
5: 31,422,681 (GRCm39) |
A923V |
possibly damaging |
Het |
Irgc |
G |
A |
7: 24,132,107 (GRCm39) |
H237Y |
probably damaging |
Het |
Itga11 |
T |
C |
9: 62,604,262 (GRCm39) |
I50T |
possibly damaging |
Het |
Itpr3 |
C |
T |
17: 27,334,887 (GRCm39) |
Q2134* |
probably null |
Het |
Kat8 |
A |
T |
7: 127,523,653 (GRCm39) |
D292V |
possibly damaging |
Het |
Kdm2a |
A |
G |
19: 4,374,392 (GRCm39) |
M913T |
possibly damaging |
Het |
Larp4 |
T |
C |
15: 99,883,961 (GRCm39) |
V66A |
probably benign |
Het |
Loxhd1 |
A |
G |
18: 77,462,858 (GRCm39) |
D899G |
probably damaging |
Het |
Lrrc47 |
G |
T |
4: 154,100,486 (GRCm39) |
R354L |
probably damaging |
Het |
Lss |
C |
T |
10: 76,367,739 (GRCm39) |
R24C |
probably damaging |
Het |
Mmp14 |
C |
T |
14: 54,673,244 (GRCm39) |
R51C |
probably damaging |
Het |
Mon1a |
C |
T |
9: 107,775,993 (GRCm39) |
T37I |
probably benign |
Het |
Mtcl2 |
A |
G |
2: 156,869,510 (GRCm39) |
W1042R |
possibly damaging |
Het |
Nacc2 |
A |
C |
2: 25,952,240 (GRCm39) |
V372G |
probably damaging |
Het |
Ncapg |
T |
C |
5: 45,849,134 (GRCm39) |
V690A |
probably benign |
Het |
Nhej1 |
A |
G |
1: 75,006,896 (GRCm39) |
L152P |
probably damaging |
Het |
Nol4l |
A |
T |
2: 153,259,337 (GRCm39) |
S522R |
probably damaging |
Het |
Nr0b2 |
A |
G |
4: 133,281,241 (GRCm39) |
Y169C |
probably damaging |
Het |
Numa1 |
A |
G |
7: 101,648,491 (GRCm39) |
M741V |
probably benign |
Het |
Or10d1b |
A |
G |
9: 39,613,453 (GRCm39) |
M204T |
possibly damaging |
Het |
Or8g28 |
A |
G |
9: 39,169,899 (GRCm39) |
L26P |
probably damaging |
Het |
Pebp1 |
C |
A |
5: 117,425,473 (GRCm39) |
|
probably null |
Het |
Pik3ip1 |
A |
T |
11: 3,291,581 (GRCm39) |
I217F |
probably damaging |
Het |
Plekhg1 |
T |
A |
10: 3,907,651 (GRCm39) |
I911N |
|
Het |
Pnpla8 |
T |
C |
12: 44,342,846 (GRCm39) |
I534T |
probably damaging |
Het |
Ppp2r2a |
A |
T |
14: 67,261,205 (GRCm39) |
F172I |
probably damaging |
Het |
Rab7 |
C |
T |
6: 87,989,292 (GRCm39) |
M59I |
probably benign |
Het |
Rbm34 |
T |
C |
8: 127,692,139 (GRCm39) |
N201S |
probably benign |
Het |
Rfx1 |
G |
T |
8: 84,821,483 (GRCm39) |
R764L |
probably damaging |
Het |
Rnase12 |
T |
A |
14: 51,294,580 (GRCm39) |
D33V |
probably damaging |
Het |
Rnf121 |
A |
G |
7: 101,684,532 (GRCm39) |
L127P |
probably damaging |
Het |
Rtl1 |
C |
A |
12: 109,560,180 (GRCm39) |
R553L |
probably damaging |
Het |
Scn8a |
T |
C |
15: 100,881,736 (GRCm39) |
L601P |
probably damaging |
Het |
Scyl2 |
G |
T |
10: 89,476,525 (GRCm39) |
Q867K |
possibly damaging |
Het |
Sgtb |
T |
C |
13: 104,268,692 (GRCm39) |
F213L |
probably benign |
Het |
Slc35f4 |
A |
G |
14: 49,551,084 (GRCm39) |
V260A |
probably damaging |
Het |
Slfn14 |
A |
G |
11: 83,174,299 (GRCm39) |
Y231H |
possibly damaging |
Het |
Sppl2b |
TGTCACAGGT |
TGT |
10: 80,701,903 (GRCm39) |
|
probably null |
Het |
Stard13 |
G |
A |
5: 151,157,106 (GRCm39) |
A25V |
possibly damaging |
Het |
Stk38 |
C |
T |
17: 29,203,161 (GRCm39) |
R135H |
probably damaging |
Het |
Svil |
A |
G |
18: 5,108,679 (GRCm39) |
D1939G |
probably damaging |
Het |
Tasor2 |
C |
T |
13: 3,625,286 (GRCm39) |
V1555I |
possibly damaging |
Het |
Tasor2 |
G |
T |
13: 3,640,016 (GRCm39) |
P374T |
probably benign |
Het |
Tbc1d7 |
A |
G |
13: 43,323,340 (GRCm39) |
V17A |
possibly damaging |
Het |
Trpc4 |
T |
C |
3: 54,129,756 (GRCm39) |
V174A |
probably damaging |
Het |
Ttn |
G |
T |
2: 76,619,028 (GRCm39) |
T16117K |
probably damaging |
Het |
Tubb3 |
T |
A |
8: 124,147,868 (GRCm39) |
M267K |
possibly damaging |
Het |
Upk1b |
T |
C |
16: 38,604,585 (GRCm39) |
T147A |
probably damaging |
Het |
Vmn2r107 |
G |
T |
17: 20,580,614 (GRCm39) |
C517F |
probably damaging |
Het |
Vmn2r112 |
A |
G |
17: 22,824,140 (GRCm39) |
D465G |
probably damaging |
Het |
Vmn2r79 |
A |
G |
7: 86,686,726 (GRCm39) |
I702M |
possibly damaging |
Het |
Vmn2r84 |
A |
G |
10: 130,227,037 (GRCm39) |
V267A |
probably damaging |
Het |
Zfp445 |
T |
C |
9: 122,681,878 (GRCm39) |
I688V |
probably benign |
Het |
Zfp955a |
C |
T |
17: 33,463,087 (GRCm39) |
V15M |
probably damaging |
Het |
Zfp960 |
T |
A |
17: 17,308,202 (GRCm39) |
C305* |
probably null |
Het |
Zfp964 |
A |
G |
8: 70,116,345 (GRCm39) |
D315G |
possibly damaging |
Het |
Zmynd10 |
T |
A |
9: 107,426,516 (GRCm39) |
I183K |
possibly damaging |
Het |
|
Other mutations in Vmn2r73 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCTGCAGGACACAGATGACTATAG -3'
(R):5'- GAATTTGTACCAAATGCTATGGAGC -3'
Sequencing Primer
(F):5'- CACAGATGACTATAGTGGGATGACC -3'
(R):5'- ATGGAGCTTGCACATTTAAATTTAC -3'
|
Posted On |
2020-07-28 |