Mutagenetix > Incidental Mutation

Incidental Mutation 'R8263:Vmn2r107'

639828

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R8263 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 20360352 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 517 (C517F)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: C517F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: C517F

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630095N17Rik	T	A	1: 75,232,039	R12S	unknown	Het
Ankrd10	C	T	8: 11,615,707	V298I	probably benign	Het
Atg4d	T	A	9: 21,267,039	M151K	probably damaging	Het
Casp8ap2	T	A	4: 32,644,072	H1048Q	probably damaging	Het
Cd300ld2	A	G	11: 115,012,366	S218P	unknown	Het
Clec3a	T	C	8: 114,425,629	V125A	probably benign	Het
Cnot6	A	T	11: 49,682,175	Y241N	probably damaging	Het
Dnah1	A	T	14: 31,293,177	F1686Y	probably damaging	Het
Dnah12	A	G	14: 26,891,464	K1285E	noncoding transcript	Het
Dopey2	T	C	16: 93,762,195	S610P	possibly damaging	Het
Ehhadh	A	T	16: 21,773,545	L136H	probably damaging	Het
Epha7	A	G	4: 28,821,149	T105A	probably damaging	Het
Etl4	A	T	2: 20,744,154	E434D	probably benign	Het
Fam208b	C	T	13: 3,575,286	V1555I	possibly damaging	Het
Fam208b	G	T	13: 3,590,016	P374T	probably benign	Het
Fam26e	C	A	10: 34,096,196	C81F	probably damaging	Het
Fastkd2	T	C	1: 63,731,809	V108A	probably benign	Het
Fat2	G	A	11: 55,284,136	T1917I	probably benign	Het
Fbxo45	A	G	16: 32,246,715	S33P	unknown	Het
Fig4	A	T	10: 41,267,715	Y249*	probably null	Het
Fryl	T	C	5: 73,081,005	Y1466C	probably damaging	Het
G530012D18Rik	C	G	1: 85,577,214	D113E	unknown	Het
Glod4	T	C	11: 76,234,492	D147G	possibly damaging	Het
Gm12695	T	G	4: 96,762,809	M136L	probably benign	Het
Gm5422	A	G	10: 31,249,103	T313A	noncoding transcript	Het
Hydin	C	A	8: 110,452,073	A1100D	probably benign	Het
Ift172	G	A	5: 31,265,337	A923V	possibly damaging	Het
Irgc1	G	A	7: 24,432,682	H237Y	probably damaging	Het
Itga11	T	C	9: 62,696,980	I50T	possibly damaging	Het
Itpr3	C	T	17: 27,115,913	Q2134*	probably null	Het
Kat8	A	T	7: 127,924,481	D292V	possibly damaging	Het
Kdm2a	A	G	19: 4,324,364	M913T	possibly damaging	Het
Larp4	T	C	15: 99,986,080	V66A	probably benign	Het
Loxhd1	A	G	18: 77,375,162	D899G	probably damaging	Het
Lrrc47	G	T	4: 154,016,029	R354L	probably damaging	Het
Lss	C	T	10: 76,531,905	R24C	probably damaging	Het
Mmp14	C	T	14: 54,435,787	R51C	probably damaging	Het
Mon1a	C	T	9: 107,898,794	T37I	probably benign	Het
Nacc2	A	C	2: 26,062,228	V372G	probably damaging	Het
Ncapg	T	C	5: 45,691,792	V690A	probably benign	Het
Nhej1	A	G	1: 74,967,737	L152P	probably damaging	Het
Nol4l	A	T	2: 153,417,417	S522R	probably damaging	Het
Nr0b2	A	G	4: 133,553,930	Y169C	probably damaging	Het
Numa1	A	G	7: 101,999,284	M741V	probably benign	Het
Olfr149	A	G	9: 39,702,157	M204T	possibly damaging	Het
Olfr945	A	G	9: 39,258,603	L26P	probably damaging	Het
Pebp1	C	A	5: 117,287,408		probably null	Het
Pik3ip1	A	T	11: 3,341,581	I217F	probably damaging	Het
Plekhg1	T	A	10: 3,957,651	I911N		Het
Pnpla8	T	C	12: 44,296,063	I534T	probably damaging	Het
Ppp2r2a	A	T	14: 67,023,756	F172I	probably damaging	Het
Rab7	C	T	6: 88,012,310	M59I	probably benign	Het
Rbm34	T	C	8: 126,965,389	N201S	probably benign	Het
Rfx1	G	T	8: 84,094,854	R764L	probably damaging	Het
Rnase12	T	A	14: 51,057,123	D33V	probably damaging	Het
Rnf121	A	G	7: 102,035,325	L127P	probably damaging	Het
Rtl1	C	A	12: 109,593,746	R553L	probably damaging	Het
Scn8a	T	C	15: 100,983,855	L601P	probably damaging	Het
Scyl2	G	T	10: 89,640,663	Q867K	possibly damaging	Het
Sgtb	T	C	13: 104,132,184	F213L	probably benign	Het
Slc35f4	A	G	14: 49,313,627	V260A	probably damaging	Het
Slfn14	A	G	11: 83,283,473	Y231H	possibly damaging	Het
Soga1	A	G	2: 157,027,590	W1042R	possibly damaging	Het
Sppl2b	TGTCACAGGT	TGT	10: 80,866,069		probably null	Het
Stard13	G	A	5: 151,233,641	A25V	possibly damaging	Het
Stk38	C	T	17: 28,984,187	R135H	probably damaging	Het
Svil	A	G	18: 5,108,679	D1939G	probably damaging	Het
Tbc1d7	A	G	13: 43,169,864	V17A	possibly damaging	Het
Trpc4	T	C	3: 54,222,335	V174A	probably damaging	Het
Ttn	G	T	2: 76,788,684	T16117K	probably damaging	Het
Tubb3	T	A	8: 123,421,129	M267K	possibly damaging	Het
Upk1b	T	C	16: 38,784,223	T147A	probably damaging	Het
Vmn2r112	A	G	17: 22,605,159	D465G	probably damaging	Het
Vmn2r73	A	T	7: 85,858,411	H564Q	probably benign	Het
Vmn2r79	A	G	7: 87,037,518	I702M	possibly damaging	Het
Vmn2r84	A	G	10: 130,391,168	V267A	probably damaging	Het
Zfp445	T	C	9: 122,852,813	I688V	probably benign	Het
Zfp955a	C	T	17: 33,244,113	V15M	probably damaging	Het
Zfp960	T	A	17: 17,087,940	C305*	probably null	Het
Zfp964	A	G	8: 69,663,695	D315G	possibly damaging	Het
Zmynd10	T	A	9: 107,549,317	I183K	possibly damaging	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- ACTGAATAGCATTTAAAACTCAGGAT -3'
(R):5'- CAAGGGGATTGTGATGAATAATGTTTA -3'

Sequencing Primer
(F):5'- ctgagacagggtttctctt -3'
(R):5'- TGTGAATTCCAGTGGAGA -3'

Posted On

2020-07-28