Incidental Mutation 'R8260:Ints1'
| ID |
639988 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ints1
|
| Ensembl Gene |
ENSMUSG00000029547 |
| Gene Name |
integrator complex subunit 1 |
| Synonyms |
1110015K06Rik |
| MMRRC Submission |
067685-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8260 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
139737037-139761429 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 139750968 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 810
(T810A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072406
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072607]
[ENSMUST00000200393]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000072406
Gene: ENSMUSG00000029547
AA Change: T810A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
102 |
N/A |
INTRINSIC |
|
Pfam:DUF3677
|
379 |
459 |
6.4e-37 |
PFAM |
|
low complexity region
|
854 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
876 |
N/A |
INTRINSIC |
|
low complexity region
|
946 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
965 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1034 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1058 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1361 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1615 |
1624 |
N/A |
INTRINSIC |
|
low complexity region
|
1763 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1840 |
1855 |
N/A |
INTRINSIC |
|
low complexity region
|
2062 |
2076 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184414
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196319
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196379
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197156
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197727
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200339
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200393
AA Change: T812A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000143789
Gene: ENSMUSG00000029547
AA Change: T812A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
102 |
N/A |
INTRINSIC |
|
Pfam:DUF3677
|
379 |
459 |
6.4e-37 |
PFAM |
|
low complexity region
|
854 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
876 |
N/A |
INTRINSIC |
|
low complexity region
|
946 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
965 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1034 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1058 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1361 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1615 |
1624 |
N/A |
INTRINSIC |
|
low complexity region
|
1763 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1840 |
1855 |
N/A |
INTRINSIC |
|
low complexity region
|
2062 |
2076 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0694 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(10) : Targeted, knock-out(1) Gene trapped(9) |
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578I06Rik |
G |
C |
14: 64,223,633 (GRCm39) |
L48V |
probably benign |
Het |
| Acbd3 |
T |
C |
1: 180,566,095 (GRCm39) |
Y263H |
probably damaging |
Het |
| Acot4 |
C |
A |
12: 84,088,809 (GRCm39) |
P219Q |
possibly damaging |
Het |
| Adcy6 |
A |
G |
15: 98,498,919 (GRCm39) |
F294S |
probably damaging |
Het |
| Ahcyl |
T |
C |
16: 45,974,786 (GRCm39) |
E197G |
probably damaging |
Het |
| Aplf |
T |
C |
6: 87,606,987 (GRCm39) |
R476G |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,382,788 (GRCm39) |
T1292A |
probably benign |
Het |
| Atp2c1 |
T |
A |
9: 105,295,778 (GRCm39) |
I649F |
probably damaging |
Het |
| Bbs10 |
C |
T |
10: 111,136,104 (GRCm39) |
Q406* |
probably null |
Het |
| Bcas3 |
T |
A |
11: 85,400,372 (GRCm39) |
M447K |
possibly damaging |
Het |
| Bmal1 |
A |
T |
7: 112,884,258 (GRCm39) |
I92F |
probably damaging |
Het |
| Cars1 |
T |
C |
7: 143,139,446 (GRCm39) |
D214G |
probably benign |
Het |
| Ccdc88a |
A |
T |
11: 29,443,934 (GRCm39) |
I1410F |
probably benign |
Het |
| Cd55b |
A |
T |
1: 130,316,415 (GRCm39) |
L378H |
probably damaging |
Het |
| Cdh1 |
G |
A |
8: 107,330,979 (GRCm39) |
E37K |
probably benign |
Het |
| Cep72 |
T |
C |
13: 74,206,465 (GRCm39) |
Y119C |
probably damaging |
Het |
| Ctnnd2 |
A |
G |
15: 30,634,879 (GRCm39) |
T176A |
possibly damaging |
Het |
| D630045J12Rik |
T |
A |
6: 38,119,846 (GRCm39) |
|
probably null |
Het |
| Ddi1 |
A |
T |
9: 6,265,524 (GRCm39) |
C282S |
probably damaging |
Het |
| Ddit4 |
T |
C |
10: 59,787,277 (GRCm39) |
T20A |
probably benign |
Het |
| Dpp10 |
T |
A |
1: 123,614,024 (GRCm39) |
T102S |
probably benign |
Het |
| Ep400 |
T |
A |
5: 110,903,478 (GRCm39) |
K374* |
probably null |
Het |
| Epha3 |
A |
G |
16: 63,403,917 (GRCm39) |
L728P |
probably damaging |
Het |
| Fbxw21 |
C |
A |
9: 108,975,614 (GRCm39) |
|
probably null |
Het |
| Frmpd1 |
A |
G |
4: 45,244,638 (GRCm39) |
E109G |
probably damaging |
Het |
| Ggt1 |
C |
T |
10: 75,417,245 (GRCm39) |
P332L |
probably damaging |
Het |
| Gm4779 |
G |
C |
X: 100,837,390 (GRCm39) |
T171S |
possibly damaging |
Het |
| Gm5431 |
A |
T |
11: 48,785,556 (GRCm39) |
I273K |
probably benign |
Het |
| Gon4l |
A |
G |
3: 88,799,937 (GRCm39) |
N861D |
probably damaging |
Het |
| Grm5 |
T |
C |
7: 87,724,340 (GRCm39) |
|
probably null |
Het |
| Helt |
T |
C |
8: 46,745,745 (GRCm39) |
N84S |
possibly damaging |
Het |
| Hnrnpa0 |
G |
T |
13: 58,275,228 (GRCm39) |
Y300* |
probably null |
Het |
| Irf2bp1 |
C |
T |
7: 18,740,079 (GRCm39) |
A573V |
possibly damaging |
Het |
| Itgbl1 |
C |
A |
14: 124,065,246 (GRCm39) |
D133E |
probably benign |
Het |
| Kctd15 |
A |
G |
7: 34,344,267 (GRCm39) |
F128S |
possibly damaging |
Het |
| Klra17 |
T |
A |
6: 129,808,421 (GRCm39) |
N271Y |
probably damaging |
Het |
| Kmt2c |
T |
A |
5: 25,610,514 (GRCm39) |
E197D |
possibly damaging |
Het |
| Larp1 |
C |
A |
11: 57,949,515 (GRCm39) |
T1048K |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,365,863 (GRCm39) |
V2966A |
probably benign |
Het |
| Magi3 |
A |
G |
3: 103,922,625 (GRCm39) |
L1364P |
probably benign |
Het |
| Malrd1 |
T |
C |
2: 15,619,017 (GRCm39) |
S294P |
|
Het |
| Med13l |
C |
T |
5: 118,886,794 (GRCm39) |
T1565I |
possibly damaging |
Het |
| Mov10l1 |
A |
G |
15: 88,896,313 (GRCm39) |
D719G |
probably benign |
Het |
| Mtcl3 |
T |
A |
10: 29,024,270 (GRCm39) |
H395Q |
possibly damaging |
Het |
| Muc4 |
CAC |
CACTAC |
16: 32,575,367 (GRCm39) |
|
probably benign |
Het |
| Myh14 |
T |
C |
7: 44,264,800 (GRCm39) |
E1654G |
probably damaging |
Het |
| Myo1c |
C |
T |
11: 75,546,942 (GRCm39) |
|
probably benign |
Het |
| Myo9a |
A |
G |
9: 59,817,961 (GRCm39) |
T2343A |
probably benign |
Het |
| Or1j12 |
A |
G |
2: 36,342,897 (GRCm39) |
Q100R |
probably damaging |
Het |
| Or2ag18 |
A |
T |
7: 106,405,234 (GRCm39) |
V145E |
possibly damaging |
Het |
| Or2d2b |
A |
T |
7: 106,706,062 (GRCm39) |
M2K |
probably benign |
Het |
| Or4m1 |
T |
C |
14: 50,557,615 (GRCm39) |
K226E |
probably benign |
Het |
| Or52m2 |
T |
A |
7: 102,263,432 (GRCm39) |
I255F |
possibly damaging |
Het |
| Or52n5 |
T |
A |
7: 104,587,879 (GRCm39) |
Y49N |
probably damaging |
Het |
| Or6c2 |
T |
A |
10: 129,362,957 (GRCm39) |
I287N |
possibly damaging |
Het |
| Or8k53 |
T |
A |
2: 86,177,276 (GRCm39) |
Y278F |
possibly damaging |
Het |
| Or9g3 |
A |
T |
2: 85,589,820 (GRCm39) |
L300Q |
probably damaging |
Het |
| Osmr |
A |
T |
15: 6,844,897 (GRCm39) |
D957E |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,234,419 (GRCm39) |
V1408E |
probably damaging |
Het |
| Pcnx3 |
C |
T |
19: 5,715,412 (GRCm39) |
G1946E |
probably damaging |
Het |
| Pdcd6ip |
A |
T |
9: 113,501,865 (GRCm39) |
D464E |
probably benign |
Het |
| Pde1c |
T |
C |
6: 56,114,404 (GRCm39) |
Y503C |
probably benign |
Het |
| Potefam3d |
A |
T |
8: 69,972,400 (GRCm39) |
D116E |
possibly damaging |
Het |
| Prob1 |
T |
A |
18: 35,787,210 (GRCm39) |
E348V |
possibly damaging |
Het |
| Rnls |
A |
G |
19: 33,180,048 (GRCm39) |
L134S |
probably damaging |
Het |
| Scrn3 |
T |
C |
2: 73,166,202 (GRCm39) |
Y412H |
probably damaging |
Het |
| Serpina3g |
T |
C |
12: 104,205,362 (GRCm39) |
S34P |
probably benign |
Het |
| Sertad3 |
G |
A |
7: 27,175,784 (GRCm39) |
A73T |
probably benign |
Het |
| Sez6l |
C |
T |
5: 112,609,122 (GRCm39) |
A576T |
probably benign |
Het |
| Sh3tc2 |
G |
A |
18: 62,146,137 (GRCm39) |
R1172H |
probably damaging |
Het |
| Sirt3 |
A |
G |
7: 140,456,319 (GRCm39) |
V110A |
|
Het |
| Smpd3 |
A |
T |
8: 106,984,047 (GRCm39) |
D557E |
probably benign |
Het |
| Sptssb |
A |
T |
3: 69,728,305 (GRCm39) |
M44K |
probably damaging |
Het |
| Tars2 |
A |
G |
3: 95,662,132 (GRCm39) |
W7R |
probably damaging |
Het |
| Tbc1d9b |
A |
G |
11: 50,055,013 (GRCm39) |
D964G |
probably benign |
Het |
| Tiam2 |
A |
T |
17: 3,568,594 (GRCm39) |
D1580V |
possibly damaging |
Het |
| Tmeff2 |
T |
A |
1: 50,977,478 (GRCm39) |
V130D |
probably damaging |
Het |
| Top2a |
T |
A |
11: 98,891,595 (GRCm39) |
E1176V |
probably null |
Het |
| Trappc9 |
C |
A |
15: 72,813,758 (GRCm39) |
E680* |
probably null |
Het |
| Trip10 |
A |
G |
17: 57,564,314 (GRCm39) |
N355S |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,596,337 (GRCm39) |
E20192G |
probably damaging |
Het |
| Vmn2r96 |
A |
G |
17: 18,804,243 (GRCm39) |
M306V |
probably benign |
Het |
| Wdr90 |
A |
T |
17: 26,064,141 (GRCm39) |
H1860Q |
probably damaging |
Het |
| Wrnip1 |
A |
G |
13: 32,989,339 (GRCm39) |
I276V |
possibly damaging |
Het |
| Zfp608 |
T |
C |
18: 55,030,821 (GRCm39) |
K1040E |
possibly damaging |
Het |
| Zfp808 |
T |
A |
13: 62,320,552 (GRCm39) |
C594S |
probably benign |
Het |
|
| Other mutations in Ints1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Ints1
|
APN |
5 |
139,757,437 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01329:Ints1
|
APN |
5 |
139,753,258 (GRCm39) |
splice site |
probably benign |
|
|
IGL01414:Ints1
|
APN |
5 |
139,744,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01612:Ints1
|
APN |
5 |
139,742,047 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01726:Ints1
|
APN |
5 |
139,754,166 (GRCm39) |
splice site |
probably benign |
|
|
IGL01958:Ints1
|
APN |
5 |
139,745,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02122:Ints1
|
APN |
5 |
139,750,905 (GRCm39) |
nonsense |
probably null |
|
|
IGL02149:Ints1
|
APN |
5 |
139,737,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Ints1
|
APN |
5 |
139,754,223 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02557:Ints1
|
APN |
5 |
139,757,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Ints1
|
APN |
5 |
139,758,146 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02815:Ints1
|
APN |
5 |
139,741,037 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02825:Ints1
|
APN |
5 |
139,750,494 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03000:Ints1
|
APN |
5 |
139,752,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03164:Ints1
|
APN |
5 |
139,738,490 (GRCm39) |
missense |
probably damaging |
0.99 |
|
forgiving
|
UTSW |
5 |
139,753,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
restrained
|
UTSW |
5 |
139,753,481 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
A9681:Ints1
|
UTSW |
5 |
139,755,894 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0113:Ints1
|
UTSW |
5 |
139,750,968 (GRCm39) |
missense |
|
|
|
R0193:Ints1
|
UTSW |
5 |
139,737,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0372:Ints1
|
UTSW |
5 |
139,758,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1129:Ints1
|
UTSW |
5 |
139,744,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1290:Ints1
|
UTSW |
5 |
139,757,165 (GRCm39) |
nonsense |
probably null |
|
|
R1313:Ints1
|
UTSW |
5 |
139,748,661 (GRCm39) |
missense |
probably benign |
|
|
R1313:Ints1
|
UTSW |
5 |
139,748,661 (GRCm39) |
missense |
probably benign |
|
|
R1691:Ints1
|
UTSW |
5 |
139,754,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1708:Ints1
|
UTSW |
5 |
139,748,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1791:Ints1
|
UTSW |
5 |
139,760,277 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2066:Ints1
|
UTSW |
5 |
139,753,251 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2102:Ints1
|
UTSW |
5 |
139,741,754 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2108:Ints1
|
UTSW |
5 |
139,753,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2238:Ints1
|
UTSW |
5 |
139,750,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2426:Ints1
|
UTSW |
5 |
139,757,569 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2913:Ints1
|
UTSW |
5 |
139,743,668 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3896:Ints1
|
UTSW |
5 |
139,743,399 (GRCm39) |
nonsense |
probably null |
|
|
R4608:Ints1
|
UTSW |
5 |
139,745,599 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4658:Ints1
|
UTSW |
5 |
139,760,054 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4797:Ints1
|
UTSW |
5 |
139,757,631 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4887:Ints1
|
UTSW |
5 |
139,756,911 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4944:Ints1
|
UTSW |
5 |
139,743,847 (GRCm39) |
splice site |
probably null |
|
|
R4956:Ints1
|
UTSW |
5 |
139,742,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Ints1
|
UTSW |
5 |
139,738,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5283:Ints1
|
UTSW |
5 |
139,750,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5354:Ints1
|
UTSW |
5 |
139,752,183 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5496:Ints1
|
UTSW |
5 |
139,740,953 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5517:Ints1
|
UTSW |
5 |
139,738,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5696:Ints1
|
UTSW |
5 |
139,740,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5766:Ints1
|
UTSW |
5 |
139,757,900 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6359:Ints1
|
UTSW |
5 |
139,741,972 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6753:Ints1
|
UTSW |
5 |
139,750,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6892:Ints1
|
UTSW |
5 |
139,753,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7009:Ints1
|
UTSW |
5 |
139,754,217 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7047:Ints1
|
UTSW |
5 |
139,744,226 (GRCm39) |
nonsense |
probably null |
|
|
R7216:Ints1
|
UTSW |
5 |
139,754,739 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7220:Ints1
|
UTSW |
5 |
139,747,828 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7263:Ints1
|
UTSW |
5 |
139,749,834 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7291:Ints1
|
UTSW |
5 |
139,750,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7319:Ints1
|
UTSW |
5 |
139,746,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7411:Ints1
|
UTSW |
5 |
139,750,015 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7497:Ints1
|
UTSW |
5 |
139,754,731 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7529:Ints1
|
UTSW |
5 |
139,753,481 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7710:Ints1
|
UTSW |
5 |
139,756,840 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7816:Ints1
|
UTSW |
5 |
139,757,134 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7819:Ints1
|
UTSW |
5 |
139,746,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7992:Ints1
|
UTSW |
5 |
139,742,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8265:Ints1
|
UTSW |
5 |
139,757,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8782:Ints1
|
UTSW |
5 |
139,744,952 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9016:Ints1
|
UTSW |
5 |
139,744,326 (GRCm39) |
missense |
probably benign |
|
|
R9053:Ints1
|
UTSW |
5 |
139,747,822 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9056:Ints1
|
UTSW |
5 |
139,760,041 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9080:Ints1
|
UTSW |
5 |
139,739,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9086:Ints1
|
UTSW |
5 |
139,743,947 (GRCm39) |
missense |
probably benign |
|
|
R9122:Ints1
|
UTSW |
5 |
139,745,930 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9134:Ints1
|
UTSW |
5 |
139,743,351 (GRCm39) |
missense |
probably benign |
|
|
R9135:Ints1
|
UTSW |
5 |
139,737,701 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9169:Ints1
|
UTSW |
5 |
139,748,586 (GRCm39) |
missense |
probably benign |
|
|
R9280:Ints1
|
UTSW |
5 |
139,750,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9458:Ints1
|
UTSW |
5 |
139,743,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Ints1
|
UTSW |
5 |
139,748,217 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ints1
|
UTSW |
5 |
139,757,393 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGGTTAGCTCTGCCTGTTC -3'
(R):5'- AGACACTGGGGCTTAACTGG -3'
Sequencing Primer
(F):5'- CCTTCCACCCACACCTGG -3'
(R):5'- CACTGGGGCTTAACTGGGTAGC -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation