Incidental Mutation 'IGL00335:Slc10a6'
ID6405
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc10a6
Ensembl Gene ENSMUSG00000029321
Gene Namesolute carrier family 10 (sodium/bile acid cotransporter family), member 6
Synonyms8430417G17Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL00335
Quality Score
Status
Chromosome5
Chromosomal Location103605711-103629403 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 103609125 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 258 (S258P)
Ref Sequence ENSEMBL: ENSMUSP00000031263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031263]
Predicted Effect probably benign
Transcript: ENSMUST00000031263
AA Change: S258P

PolyPhen 2 Score 0.158 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000031263
Gene: ENSMUSG00000029321
AA Change: S258P

DomainStartEndE-ValueType
Pfam:SBF 39 220 7.3e-43 PFAM
transmembrane domain 224 246 N/A INTRINSIC
transmembrane domain 266 283 N/A INTRINSIC
transmembrane domain 288 310 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700048O20Rik C A 9: 121,940,767 noncoding transcript Het
4930579F01Rik C A 3: 138,186,198 probably benign Het
Aurkc T A 7: 6,996,548 I18N probably damaging Het
Bace1 T C 9: 45,839,290 probably null Het
Chrne C T 11: 70,615,762 V311I probably benign Het
Cyp2c70 C T 19: 40,167,576 V177M probably damaging Het
Dusp10 A G 1: 184,069,131 E365G probably benign Het
Fam166b G A 4: 43,428,158 R100W possibly damaging Het
Fcgbp C A 7: 28,086,135 N332K possibly damaging Het
Irx4 T C 13: 73,268,691 V402A probably benign Het
Kcnq4 G A 4: 120,698,016 Q657* probably null Het
Kif14 G A 1: 136,469,018 S354N probably benign Het
Lama3 A G 18: 12,449,588 probably benign Het
Lrrc8b T C 5: 105,480,499 I237T probably damaging Het
Mepe G T 5: 104,337,977 G328C probably damaging Het
Numb A G 12: 83,808,132 I129T probably damaging Het
Olfr193 T C 16: 59,110,598 D4G probably benign Het
Olfr799 T C 10: 129,647,437 I103T probably benign Het
Osmr T C 15: 6,837,023 D390G probably benign Het
Pglyrp3 G A 3: 92,022,679 V51I probably damaging Het
Phactr2 T C 10: 13,245,535 T470A probably damaging Het
Psmg1 G A 16: 95,980,068 T259I possibly damaging Het
Rtl3 T C X: 106,838,937 T240A probably benign Het
Ryr1 C T 7: 29,124,960 probably null Het
Slc1a6 T C 10: 78,801,813 L391P probably damaging Het
Slc6a7 C T 18: 61,001,609 V465M possibly damaging Het
Sost T C 11: 101,966,879 D32G probably damaging Het
Sox4 C A 13: 28,952,973 G17W probably damaging Het
Tifab A G 13: 56,176,469 S54P probably damaging Het
Tmem211 A G 5: 113,236,003 R96G probably benign Het
Tnrc6a T A 7: 123,170,780 S598T probably benign Het
Vmn2r1 T A 3: 64,105,388 I890N probably damaging Het
Wapl A G 14: 34,692,636 D485G probably benign Het
Wee2 A T 6: 40,462,061 I373F probably damaging Het
Xkr6 A G 14: 63,819,215 T192A probably damaging Het
Zfp638 A G 6: 83,979,718 D1769G probably damaging Het
Other mutations in Slc10a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Slc10a6 APN 5 103612496 missense probably benign 0.01
IGL02893:Slc10a6 APN 5 103628873 missense probably benign 0.39
R0681:Slc10a6 UTSW 5 103612449 missense possibly damaging 0.65
R1300:Slc10a6 UTSW 5 103606684 missense probably benign 0.28
R1636:Slc10a6 UTSW 5 103629146 missense probably benign 0.00
R2127:Slc10a6 UTSW 5 103609056 missense probably benign 0.00
R2129:Slc10a6 UTSW 5 103609056 missense probably benign 0.00
R4789:Slc10a6 UTSW 5 103628982 missense probably benign 0.03
R4908:Slc10a6 UTSW 5 103606627 missense probably benign 0.00
R4976:Slc10a6 UTSW 5 103606604 missense probably benign 0.04
R5309:Slc10a6 UTSW 5 103609092 missense probably damaging 0.96
R6784:Slc10a6 UTSW 5 103629030 missense probably damaging 1.00
R7362:Slc10a6 UTSW 5 103629126 missense probably damaging 0.99
R7658:Slc10a6 UTSW 5 103629190 missense probably damaging 0.99
R7708:Slc10a6 UTSW 5 103629262 start gained probably benign
RF009:Slc10a6 UTSW 5 103608992 missense probably damaging 1.00
X0022:Slc10a6 UTSW 5 103612425 missense probably benign 0.00
Posted On2012-04-20