Incidental Mutation 'R8257:Or2d3b'
ID 640514
Institutional Source Beutler Lab
Gene Symbol Or2d3b
Ensembl Gene ENSMUSG00000073899
Gene Name olfactory receptor family 2 subfamily D member 3B
Synonyms GA_x6K02T2PBJ9-9297671-9298594, Olfr708, MOR260-9P, MOR260-6P, MOR260-9P, Olfr1532, Olfr1532-ps1
MMRRC Submission 067683-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R8257 (G1)
Quality Score 124.008
Status Not validated
Chromosome 7
Chromosomal Location 106507332-106514330 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106513926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 174 (I174V)
Ref Sequence ENSEMBL: ENSMUSP00000095744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098140] [ENSMUST00000207492]
AlphaFold A0A0R4J8U2
Predicted Effect probably benign
Transcript: ENSMUST00000098140
AA Change: I174V

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000095744
Gene: ENSMUSG00000073899
AA Change: I174V

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.2e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 285 5.6e-9 PFAM
Pfam:7tm_1 41 290 2.8e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207492
AA Change: I174V

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,950,153 (GRCm39) K1350R probably benign Het
4933407L21Rik T A 1: 85,859,060 (GRCm39) C70* probably null Het
Akr1c6 G A 13: 4,488,525 (GRCm39) V97I probably benign Het
Alg9 A T 9: 50,690,387 (GRCm39) I130F possibly damaging Het
Ankle2 G T 5: 110,401,781 (GRCm39) probably null Het
Ankrd34a A T 3: 96,505,045 (GRCm39) H83L possibly damaging Het
Aoc1l2 A G 6: 48,909,431 (GRCm39) T559A probably benign Het
Ate1 T C 7: 130,069,037 (GRCm39) Y367C probably damaging Het
Atg9b C T 5: 24,591,303 (GRCm39) probably benign Het
Atp2c1 A G 9: 105,308,756 (GRCm39) S626P probably benign Het
Ccdc171 A G 4: 83,614,606 (GRCm39) N1069S probably damaging Het
Cdh20 A G 1: 104,921,962 (GRCm39) D753G probably benign Het
Cdk11b A G 4: 155,732,398 (GRCm39) E517G unknown Het
Chst5 A T 8: 112,617,092 (GRCm39) V176E probably damaging Het
Ddx50 T C 10: 62,452,299 (GRCm39) probably benign Het
Dspp A G 5: 104,324,867 (GRCm39) D410G probably benign Het
Dync1h1 T A 12: 110,602,908 (GRCm39) V2183E probably damaging Het
Emilin2 A G 17: 71,580,995 (GRCm39) V577A probably benign Het
Entpd2 T A 2: 25,288,133 (GRCm39) L119Q probably damaging Het
Foxa1 A T 12: 57,589,932 (GRCm39) M96K probably benign Het
Ggnbp2 C T 11: 84,728,815 (GRCm39) probably null Het
H2-Aa T C 17: 34,502,211 (GRCm39) T237A probably damaging Het
Itih4 G A 14: 30,609,825 (GRCm39) V52I possibly damaging Het
Kntc1 T C 5: 123,896,586 (GRCm39) probably null Het
Lgi4 A T 7: 30,766,766 (GRCm39) probably null Het
Map4k2 G A 19: 6,396,030 (GRCm39) R455H probably benign Het
Masp2 A G 4: 148,687,497 (GRCm39) T95A possibly damaging Het
Mtmr12 T C 15: 12,259,684 (GRCm39) I351T possibly damaging Het
Ncdn A G 4: 126,643,676 (GRCm39) probably null Het
Nckipsd A G 9: 108,692,127 (GRCm39) E516G probably benign Het
Nlrp12 A G 7: 3,297,962 (GRCm39) W70R probably damaging Het
Nmral1 T A 16: 4,534,267 (GRCm39) D58V probably damaging Het
Nr2c1 A G 10: 94,028,769 (GRCm39) Y522C probably damaging Het
Or14c45 A G 7: 86,176,678 (GRCm39) T238A possibly damaging Het
Or1e23 A G 11: 73,407,203 (GRCm39) M274T probably benign Het
Or2w1b A G 13: 21,300,543 (GRCm39) N227S probably benign Het
Pcdhga6 T A 18: 37,841,868 (GRCm39) N529K probably benign Het
Pkmyt1 C T 17: 23,953,148 (GRCm39) R235W probably benign Het
Prss43 T C 9: 110,659,880 (GRCm39) S315P possibly damaging Het
Psmd1 T A 1: 86,006,345 (GRCm39) V237E probably damaging Het
Ptprf A G 4: 118,083,476 (GRCm39) Y844H probably damaging Het
Ryr1 C T 7: 28,764,064 (GRCm39) V3089I possibly damaging Het
Slc1a7 A G 4: 107,865,394 (GRCm39) D294G possibly damaging Het
Slc5a10 T A 11: 61,605,873 (GRCm39) T148S probably damaging Het
Spata25 T C 2: 164,669,690 (GRCm39) D107G possibly damaging Het
Stambpl1 A G 19: 34,208,901 (GRCm39) E132G probably damaging Het
Tgfb1 A G 7: 25,396,373 (GRCm39) H222R probably damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Trmt1l T A 1: 151,304,629 (GRCm39) M1K probably null Het
Vmn2r86 A T 10: 130,288,279 (GRCm39) H407Q possibly damaging Het
Wdr36 T A 18: 32,974,339 (GRCm39) probably benign Het
Zfp35 T A 18: 24,137,288 (GRCm39) I544N possibly damaging Het
Other mutations in Or2d3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Or2d3b APN 7 106,514,235 (GRCm39) missense probably damaging 1.00
PIT4402001:Or2d3b UTSW 7 106,514,294 (GRCm39) missense possibly damaging 0.49
PIT4453001:Or2d3b UTSW 7 106,514,136 (GRCm39) missense probably damaging 1.00
R0008:Or2d3b UTSW 7 106,514,226 (GRCm39) missense probably benign 0.02
R0848:Or2d3b UTSW 7 106,514,200 (GRCm39) missense probably benign 0.01
R0894:Or2d3b UTSW 7 106,514,317 (GRCm39) missense probably benign 0.20
R1866:Or2d3b UTSW 7 106,514,273 (GRCm39) missense probably damaging 0.98
R1970:Or2d3b UTSW 7 106,513,453 (GRCm39) missense probably damaging 1.00
R2258:Or2d3b UTSW 7 106,514,113 (GRCm39) missense probably damaging 1.00
R7003:Or2d3b UTSW 7 106,514,319 (GRCm39) missense probably benign
R8981:Or2d3b UTSW 7 106,513,590 (GRCm39) missense probably benign 0.24
R9223:Or2d3b UTSW 7 106,513,980 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- GTCCTATGACCGCTATGTGG -3'
(R):5'- CCTGAGCCGTAGAAGAGAAC -3'

Sequencing Primer
(F):5'- CTATGTGGCTGTCTGCAAGCC -3'
(R):5'- TGGAGAAGACCTTGAGCCTTC -3'
Posted On 2020-07-28