Incidental Mutation 'R0096:Vmn1r69'
ID 64060
Institutional Source Beutler Lab
Gene Symbol Vmn1r69
Ensembl Gene ENSMUSG00000091662
Gene Name vomeronasal 1 receptor 69
Synonyms V1re9
MMRRC Submission 038382-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0096 (G1)
Quality Score 109
Status Validated
Chromosome 7
Chromosomal Location 10313683-10315414 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10313985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 170 (I170F)
Ref Sequence ENSEMBL: ENSMUSP00000154473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163658] [ENSMUST00000176284] [ENSMUST00000176707] [ENSMUST00000226160] [ENSMUST00000226190] [ENSMUST00000226228] [ENSMUST00000227853] [ENSMUST00000228296] [ENSMUST00000228638] [ENSMUST00000228478]
AlphaFold Q8VIC1
Predicted Effect probably damaging
Transcript: ENSMUST00000163658
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129646
Gene: ENSMUSG00000091662
AA Change: I249F

DomainStartEndE-ValueType
Pfam:V1R 50 307 3.3e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176284
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000176707
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226160
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226190
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226228
AA Change: I249F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227853
AA Change: I170F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228296
AA Change: I170F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228638
AA Change: I170F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228478
AA Change: I170F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226990
Meta Mutation Damage Score 0.7170 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 93.5%
Validation Efficiency 100% (69/69)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A T 8: 106,435,563 (GRCm39) probably null Het
Adamts3 G A 5: 89,849,576 (GRCm39) Q615* probably null Het
Adamtsl3 T A 7: 82,114,907 (GRCm39) probably benign Het
Anks1b T C 10: 89,909,924 (GRCm39) S48P possibly damaging Het
Aoc1l2 A C 6: 48,908,122 (GRCm39) Q374P probably damaging Het
Arfip2 T A 7: 105,287,437 (GRCm39) K94N probably damaging Het
Arhgap42 G T 9: 9,009,314 (GRCm39) N524K probably damaging Het
Arhgef28 T G 13: 98,067,762 (GRCm39) T1388P probably damaging Het
Arid4b T C 13: 14,303,779 (GRCm39) V68A probably benign Het
BC005537 T C 13: 24,989,923 (GRCm39) F129L probably damaging Het
Capn3 A T 2: 120,333,010 (GRCm39) H592L possibly damaging Het
Dglucy A T 12: 100,804,910 (GRCm39) I134F possibly damaging Het
Dhh T A 15: 98,791,869 (GRCm39) M380L probably benign Het
Dnai2 A C 11: 114,645,158 (GRCm39) D531A probably benign Het
Dthd1 A T 5: 63,000,383 (GRCm39) R568S possibly damaging Het
Efr3a A G 15: 65,727,290 (GRCm39) N613S probably damaging Het
Epb41l5 T A 1: 119,551,641 (GRCm39) probably benign Het
Ermp1 A G 19: 29,608,788 (GRCm39) Y164H possibly damaging Het
Fam120c CCAGCAGCAGCAGCAGCA CCAGCAGCAGCAGCA X: 150,127,341 (GRCm39) probably benign Het
Fbrs C T 7: 127,088,659 (GRCm39) A145V probably damaging Het
Gm4736 T C 6: 132,092,569 (GRCm39) noncoding transcript Het
Gm9873 A T 2: 168,863,029 (GRCm39) noncoding transcript Het
Grik1 T C 16: 87,831,114 (GRCm39) M219V possibly damaging Het
Gtsf1l C T 2: 162,929,456 (GRCm39) C9Y probably damaging Het
Itih5 G A 2: 10,256,189 (GRCm39) R885Q probably benign Het
Kdm4c A G 4: 74,275,580 (GRCm39) E752G probably damaging Het
Ksr1 A G 11: 78,929,073 (GRCm39) probably benign Het
Lama1 T A 17: 68,112,408 (GRCm39) F2283I probably benign Het
Luc7l3 A G 11: 94,192,320 (GRCm39) probably benign Het
Lypd8 A T 11: 58,277,583 (GRCm39) M122L probably benign Het
Map1a A G 2: 121,131,986 (GRCm39) E696G probably damaging Het
Mrps34 A G 17: 25,114,643 (GRCm39) D110G probably damaging Het
Myh11 T A 16: 14,022,231 (GRCm39) K1710M possibly damaging Het
Myo1d A G 11: 80,375,158 (GRCm39) L972P probably damaging Het
Nos1ap T C 1: 170,156,816 (GRCm39) D214G probably damaging Het
Or4c119 A T 2: 88,986,640 (GRCm39) M293K probably benign Het
Or8b46 A T 9: 38,450,832 (GRCm39) I214F probably damaging Het
Pate4 T G 9: 35,523,130 (GRCm39) T5P probably damaging Het
Pygl A T 12: 70,237,940 (GRCm39) probably benign Het
Samd4 A T 14: 47,301,754 (GRCm39) M252L possibly damaging Het
Serpinb1c T A 13: 33,070,266 (GRCm39) probably benign Het
Sis A T 3: 72,835,600 (GRCm39) W921R probably damaging Het
Skint5 A T 4: 113,454,965 (GRCm39) probably benign Het
Slc27a6 T C 18: 58,731,829 (GRCm39) probably benign Het
Sycp2 G T 2: 178,045,528 (GRCm39) Q31K probably damaging Het
Taar7f A G 10: 23,926,152 (GRCm39) M249V probably benign Het
Tarm1 T C 7: 3,546,067 (GRCm39) T79A probably benign Het
Tektl1 T A 10: 78,584,539 (GRCm39) I328L probably benign Het
Trf A G 9: 103,099,358 (GRCm39) F300L probably damaging Het
Vmn2r105 A G 17: 20,447,741 (GRCm39) F361S possibly damaging Het
Vmn2r79 A G 7: 86,686,527 (GRCm39) Y636C probably damaging Het
Wdr59 T C 8: 112,231,005 (GRCm39) N68D probably damaging Het
Zfp345 T A 2: 150,314,220 (GRCm39) H439L probably damaging Het
Other mutations in Vmn1r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Vmn1r69 APN 7 10,313,879 (GRCm39) missense probably benign 0.00
IGL01972:Vmn1r69 APN 7 10,314,586 (GRCm39) nonsense probably null
IGL02339:Vmn1r69 APN 7 10,314,645 (GRCm39) nonsense probably null
IGL02424:Vmn1r69 APN 7 10,314,585 (GRCm39) missense probably benign 0.00
IGL02602:Vmn1r69 APN 7 10,313,901 (GRCm39) missense probably benign 0.14
IGL03271:Vmn1r69 APN 7 10,314,596 (GRCm39) missense probably benign 0.11
R0034:Vmn1r69 UTSW 7 10,314,738 (GRCm39) intron probably benign
R0052:Vmn1r69 UTSW 7 10,314,327 (GRCm39) missense probably benign 0.00
R0539:Vmn1r69 UTSW 7 10,314,874 (GRCm39) splice site probably benign
R0604:Vmn1r69 UTSW 7 10,314,581 (GRCm39) missense probably benign 0.00
R1681:Vmn1r69 UTSW 7 10,314,179 (GRCm39) missense probably benign 0.06
R1884:Vmn1r69 UTSW 7 10,314,678 (GRCm39) missense probably benign 0.00
R3741:Vmn1r69 UTSW 7 10,314,069 (GRCm39) missense possibly damaging 0.47
R4655:Vmn1r69 UTSW 7 10,314,026 (GRCm39) missense probably benign 0.03
R4735:Vmn1r69 UTSW 7 10,314,926 (GRCm39) utr 5 prime probably benign
R4758:Vmn1r69 UTSW 7 10,314,473 (GRCm39) missense probably benign 0.00
R5582:Vmn1r69 UTSW 7 10,314,435 (GRCm39) missense probably damaging 1.00
R5966:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R5977:Vmn1r69 UTSW 7 10,314,417 (GRCm39) missense probably damaging 1.00
R6458:Vmn1r69 UTSW 7 10,314,365 (GRCm39) missense probably benign
R6987:Vmn1r69 UTSW 7 10,314,491 (GRCm39) start codon destroyed probably null 0.99
R7133:Vmn1r69 UTSW 7 10,314,995 (GRCm39) intron probably benign
R7532:Vmn1r69 UTSW 7 10,314,281 (GRCm39) missense probably damaging 0.98
R7878:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R9100:Vmn1r69 UTSW 7 10,314,064 (GRCm39) missense probably damaging 0.98
R9558:Vmn1r69 UTSW 7 10,314,185 (GRCm39) missense probably benign
Z1176:Vmn1r69 UTSW 7 10,314,023 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- GTCATGTAGGCTGCTGACTCAACC -3'
(R):5'- ATCTGCAAAGTACGTTGGCTACTCC -3'

Sequencing Primer
(F):5'- TCCTTATCCAGGTCAAACTGAG -3'
(R):5'- AAAGTACGTTGGCTACTCCTTGTC -3'
Posted On 2013-08-06