Incidental Mutation 'R8254:Vmn2r72'
ID 640652
Institutional Source Beutler Lab
Gene Symbol Vmn2r72
Ensembl Gene ENSMUSG00000051877
Gene Name vomeronasal 2, receptor 72
Synonyms Vmn2r72-ps, EG244114
MMRRC Submission 067680-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R8254 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85737784-85754981 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85751019 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 274 (D274G)
Ref Sequence ENSEMBL: ENSMUSP00000133014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063425]
AlphaFold D3Z4N8
Predicted Effect probably damaging
Transcript: ENSMUST00000063425
AA Change: D274G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: D274G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 82 469 2.3e-28 PFAM
Pfam:NCD3G 512 564 1.2e-18 PFAM
Pfam:7tm_3 594 832 4e-53 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik T C 7: 28,147,349 (GRCm38) V1119A possibly damaging Het
Aadacl3 T C 4: 144,456,190 (GRCm38) Y236C probably benign Het
Arhgef2 T C 3: 88,642,603 (GRCm38) L655P probably damaging Het
Brsk2 T C 7: 141,984,416 (GRCm38) S100P probably damaging Het
Calb1 A G 4: 15,898,926 (GRCm38) T141A probably benign Het
Cog6 T C 3: 52,993,517 (GRCm38) T447A probably benign Het
Cyp4f13 A T 17: 32,929,933 (GRCm38) N279K probably benign Het
Dnah11 T C 12: 117,878,524 (GRCm38) D4440G possibly damaging Het
Dspp A T 5: 104,175,328 (GRCm38) E112D possibly damaging Het
Fam3c T A 6: 22,328,676 (GRCm38) T71S possibly damaging Het
Fdxr C A 11: 115,271,318 (GRCm38) G188W probably damaging Het
Fndc5 T C 4: 129,138,721 (GRCm38) V39A possibly damaging Het
Gm14226 T C 2: 155,024,726 (GRCm38) I201T possibly damaging Het
Gm853 C A 4: 130,220,343 (GRCm38) A94S probably benign Het
Grip1 C T 10: 120,054,905 (GRCm38) Q950* probably null Het
Haspin A T 11: 73,136,746 (GRCm38) Y506N probably benign Het
Itga2b C A 11: 102,467,386 (GRCm38) R171L probably benign Het
Kctd2 C T 11: 115,420,348 (GRCm38) P61S unknown Het
Kirrel2 A G 7: 30,450,376 (GRCm38) probably null Het
Lmx1b A G 2: 33,565,114 (GRCm38) F310S Het
Map4k4 A T 1: 40,006,675 (GRCm38) I574F probably damaging Het
Nrip1 T C 16: 76,291,399 (GRCm38) K1090R probably benign Het
Ntrk3 T C 7: 78,192,578 (GRCm38) Y820C probably damaging Het
Olfr1446 T C 19: 12,890,485 (GRCm38) T31A probably benign Het
Olfr209 T A 16: 59,362,171 (GRCm38) I16L probably benign Het
Pcdhb11 T C 18: 37,422,189 (GRCm38) Y191H probably benign Het
Pgm5 T C 19: 24,727,725 (GRCm38) K475E probably benign Het
Pi16 C A 17: 29,319,234 (GRCm38) P7Q possibly damaging Het
Psd4 A T 2: 24,403,211 (GRCm38) D696V probably damaging Het
Rere T C 4: 150,612,672 (GRCm38) F556L unknown Het
Sema4f A T 6: 82,917,401 (GRCm38) C528S probably damaging Het
Sorcs2 A G 5: 36,038,206 (GRCm38) S680P probably benign Het
Sv2c T C 13: 96,088,565 (GRCm38) T79A probably damaging Het
Tarsl2 A G 7: 65,676,061 (GRCm38) N461S probably benign Het
Thada T C 17: 84,226,040 (GRCm38) N1661S probably benign Het
Tubd1 A T 11: 86,549,438 (GRCm38) Q96L probably damaging Het
Vps13d A T 4: 144,983,312 (GRCm38) probably benign Het
Vwce C A 19: 10,650,574 (GRCm38) S466Y probably damaging Het
Wdr11 T C 7: 129,634,836 (GRCm38) I1178T probably benign Het
Zfp568 A T 7: 30,015,133 (GRCm38) H145L probably benign Het
Zfp606 T C 7: 12,492,861 (GRCm38) I303T possibly damaging Het
Zfp846 A G 9: 20,593,291 (GRCm38) D149G probably benign Het
Other mutations in Vmn2r72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00931:Vmn2r72 APN 7 85,749,646 (GRCm38) missense probably benign 0.01
IGL01019:Vmn2r72 APN 7 85,738,334 (GRCm38) missense probably benign 0.26
IGL01445:Vmn2r72 APN 7 85,749,646 (GRCm38) missense probably benign 0.06
IGL02076:Vmn2r72 APN 7 85,738,367 (GRCm38) missense probably damaging 1.00
IGL02082:Vmn2r72 APN 7 85,738,166 (GRCm38) missense probably benign 0.00
IGL02086:Vmn2r72 APN 7 85,738,166 (GRCm38) missense probably benign 0.00
IGL02089:Vmn2r72 APN 7 85,738,166 (GRCm38) missense probably benign 0.00
IGL02125:Vmn2r72 APN 7 85,750,711 (GRCm38) missense probably benign 0.00
IGL02146:Vmn2r72 APN 7 85,737,962 (GRCm38) missense probably damaging 1.00
IGL02272:Vmn2r72 APN 7 85,750,693 (GRCm38) missense probably benign
IGL02514:Vmn2r72 APN 7 85,738,699 (GRCm38) missense possibly damaging 0.90
IGL02662:Vmn2r72 APN 7 85,738,183 (GRCm38) missense probably benign 0.26
IGL02697:Vmn2r72 APN 7 85,738,671 (GRCm38) missense probably benign 0.36
IGL02733:Vmn2r72 APN 7 85,751,813 (GRCm38) missense probably benign 0.05
IGL03070:Vmn2r72 APN 7 85,752,041 (GRCm38) splice site probably benign
IGL03150:Vmn2r72 APN 7 85,751,176 (GRCm38) missense probably damaging 1.00
IGL03159:Vmn2r72 APN 7 85,754,954 (GRCm38) missense probably benign 0.05
IGL03333:Vmn2r72 APN 7 85,750,867 (GRCm38) missense probably benign 0.10
R0081:Vmn2r72 UTSW 7 85,751,836 (GRCm38) missense probably benign 0.01
R0090:Vmn2r72 UTSW 7 85,754,876 (GRCm38) missense probably benign
R0655:Vmn2r72 UTSW 7 85,738,111 (GRCm38) nonsense probably null
R0778:Vmn2r72 UTSW 7 85,749,739 (GRCm38) missense probably benign 0.00
R1169:Vmn2r72 UTSW 7 85,751,309 (GRCm38) missense probably benign 0.01
R1172:Vmn2r72 UTSW 7 85,751,944 (GRCm38) missense probably damaging 1.00
R1173:Vmn2r72 UTSW 7 85,751,944 (GRCm38) missense probably damaging 1.00
R1175:Vmn2r72 UTSW 7 85,751,944 (GRCm38) missense probably damaging 1.00
R1248:Vmn2r72 UTSW 7 85,749,188 (GRCm38) missense probably benign 0.02
R1302:Vmn2r72 UTSW 7 85,738,257 (GRCm38) missense probably damaging 1.00
R1506:Vmn2r72 UTSW 7 85,749,211 (GRCm38) missense probably benign
R1632:Vmn2r72 UTSW 7 85,751,792 (GRCm38) missense probably benign 0.13
R1775:Vmn2r72 UTSW 7 85,738,170 (GRCm38) missense probably benign 0.01
R1962:Vmn2r72 UTSW 7 85,749,161 (GRCm38) missense probably benign 0.00
R2201:Vmn2r72 UTSW 7 85,738,236 (GRCm38) missense probably benign 0.12
R2290:Vmn2r72 UTSW 7 85,738,341 (GRCm38) missense probably damaging 1.00
R2327:Vmn2r72 UTSW 7 85,738,256 (GRCm38) missense probably damaging 1.00
R2424:Vmn2r72 UTSW 7 85,750,953 (GRCm38) missense probably damaging 1.00
R2655:Vmn2r72 UTSW 7 85,751,269 (GRCm38) missense possibly damaging 0.95
R2860:Vmn2r72 UTSW 7 85,750,836 (GRCm38) missense probably damaging 0.99
R2861:Vmn2r72 UTSW 7 85,750,836 (GRCm38) missense probably damaging 0.99
R2862:Vmn2r72 UTSW 7 85,750,836 (GRCm38) missense probably damaging 0.99
R3009:Vmn2r72 UTSW 7 85,749,642 (GRCm38) missense probably benign 0.00
R3797:Vmn2r72 UTSW 7 85,738,077 (GRCm38) missense probably benign 0.44
R3798:Vmn2r72 UTSW 7 85,738,077 (GRCm38) missense probably benign 0.44
R3902:Vmn2r72 UTSW 7 85,749,735 (GRCm38) missense possibly damaging 0.52
R3959:Vmn2r72 UTSW 7 85,751,131 (GRCm38) missense probably benign 0.36
R3974:Vmn2r72 UTSW 7 85,749,809 (GRCm38) missense probably damaging 1.00
R4399:Vmn2r72 UTSW 7 85,738,500 (GRCm38) missense probably damaging 1.00
R4421:Vmn2r72 UTSW 7 85,738,500 (GRCm38) missense probably damaging 1.00
R4426:Vmn2r72 UTSW 7 85,737,828 (GRCm38) nonsense probably null
R4522:Vmn2r72 UTSW 7 85,751,926 (GRCm38) missense probably benign 0.44
R4523:Vmn2r72 UTSW 7 85,751,926 (GRCm38) missense probably benign 0.44
R4533:Vmn2r72 UTSW 7 85,751,926 (GRCm38) missense probably benign 0.44
R4691:Vmn2r72 UTSW 7 85,737,911 (GRCm38) nonsense probably null
R4781:Vmn2r72 UTSW 7 85,737,861 (GRCm38) missense probably benign 0.14
R4863:Vmn2r72 UTSW 7 85,750,598 (GRCm38) missense possibly damaging 0.91
R4952:Vmn2r72 UTSW 7 85,751,109 (GRCm38) missense probably benign
R4991:Vmn2r72 UTSW 7 85,751,130 (GRCm38) missense probably damaging 0.99
R4995:Vmn2r72 UTSW 7 85,738,485 (GRCm38) missense probably damaging 1.00
R5095:Vmn2r72 UTSW 7 85,737,853 (GRCm38) missense probably damaging 0.98
R5174:Vmn2r72 UTSW 7 85,737,840 (GRCm38) missense probably benign 0.00
R5276:Vmn2r72 UTSW 7 85,738,254 (GRCm38) missense possibly damaging 0.90
R5395:Vmn2r72 UTSW 7 85,750,897 (GRCm38) missense possibly damaging 0.71
R5560:Vmn2r72 UTSW 7 85,751,942 (GRCm38) missense probably damaging 0.96
R5933:Vmn2r72 UTSW 7 85,737,850 (GRCm38) missense probably benign 0.05
R6033:Vmn2r72 UTSW 7 85,737,929 (GRCm38) missense probably damaging 1.00
R6033:Vmn2r72 UTSW 7 85,737,929 (GRCm38) missense probably damaging 1.00
R6354:Vmn2r72 UTSW 7 85,750,539 (GRCm38) critical splice donor site probably null
R6362:Vmn2r72 UTSW 7 85,751,174 (GRCm38) missense probably damaging 1.00
R6594:Vmn2r72 UTSW 7 85,749,684 (GRCm38) missense probably benign 0.32
R6794:Vmn2r72 UTSW 7 85,737,996 (GRCm38) missense probably damaging 1.00
R7113:Vmn2r72 UTSW 7 85,749,803 (GRCm38) splice site probably null
R7189:Vmn2r72 UTSW 7 85,754,917 (GRCm38) missense probably benign 0.36
R7266:Vmn2r72 UTSW 7 85,738,274 (GRCm38) nonsense probably null
R7323:Vmn2r72 UTSW 7 85,750,563 (GRCm38) missense probably benign
R7426:Vmn2r72 UTSW 7 85,751,140 (GRCm38) missense probably benign
R7606:Vmn2r72 UTSW 7 85,751,154 (GRCm38) missense possibly damaging 0.91
R7651:Vmn2r72 UTSW 7 85,751,938 (GRCm38) missense probably damaging 1.00
R7688:Vmn2r72 UTSW 7 85,754,890 (GRCm38) missense probably benign 0.32
R7753:Vmn2r72 UTSW 7 85,750,626 (GRCm38) missense probably damaging 1.00
R7843:Vmn2r72 UTSW 7 85,749,630 (GRCm38) missense probably benign 0.01
R8157:Vmn2r72 UTSW 7 85,751,233 (GRCm38) missense probably benign 0.09
R8389:Vmn2r72 UTSW 7 85,751,960 (GRCm38) missense probably damaging 0.99
R8444:Vmn2r72 UTSW 7 85,738,175 (GRCm38) missense probably benign
R8989:Vmn2r72 UTSW 7 85,754,926 (GRCm38) missense probably benign 0.10
R9015:Vmn2r72 UTSW 7 85,749,180 (GRCm38) missense probably benign 0.01
R9080:Vmn2r72 UTSW 7 85,738,256 (GRCm38) missense probably damaging 1.00
R9269:Vmn2r72 UTSW 7 85,751,203 (GRCm38) missense probably benign 0.03
R9317:Vmn2r72 UTSW 7 85,754,814 (GRCm38) missense probably benign 0.04
R9509:Vmn2r72 UTSW 7 85,754,867 (GRCm38) missense probably benign
Z1176:Vmn2r72 UTSW 7 85,749,191 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACCAGATATTTCGGGTTTCTGG -3'
(R):5'- CATGGTGTCCCTAATGGTTCATTTC -3'

Sequencing Primer
(F):5'- GTGACACACTAACCCAGAT -3'
(R):5'- GCGATGATTACAAATGATGACCATG -3'
Posted On 2020-07-28