Incidental Mutation 'R8240:Tmsb10b'
ID 640910
Institutional Source Beutler Lab
Gene Symbol Tmsb10b
Ensembl Gene ENSMUSG00000091955
Gene Name thymosin beta 10b
Synonyms Gm9844
MMRRC Submission 067671-MU
Accession Numbers
Essential gene? Not available question?
Stock # R8240 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 24561628-24562103 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 24561805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 35 (I35L)
Ref Sequence ENSEMBL: ENSMUSP00000137210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079306] [ENSMUST00000122995] [ENSMUST00000170837]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000079306
SMART Domains Protein: ENSMUSP00000078287
Gene: ENSMUSG00000062732

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 142 233 7.5e-23 PFAM
low complexity region 237 244 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122995
SMART Domains Protein: ENSMUSP00000122913
Gene: ENSMUSG00000062732

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170837
AA Change: I35L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610524H06Rik A T 5: 114,961,472 (GRCm39) V12E probably benign Het
Ahnak2 A G 12: 112,741,082 (GRCm39) F997L probably benign Het
Baiap3 A T 17: 25,464,288 (GRCm39) probably null Het
Cct6b A G 11: 82,614,650 (GRCm39) I446T probably damaging Het
Cfap206 A G 4: 34,728,902 (GRCm39) M1T probably null Het
Clca4a T C 3: 144,676,488 (GRCm39) Y64C probably damaging Het
Col24a1 A T 3: 145,213,457 (GRCm39) Q1354L probably benign Het
Coro7 A G 16: 4,486,660 (GRCm39) V171A probably damaging Het
Cyp3a44 G A 5: 145,725,257 (GRCm39) L315F probably damaging Het
Frem1 T A 4: 82,874,485 (GRCm39) D1379V probably benign Het
Gstm6 T A 3: 107,849,453 (GRCm39) D119V probably damaging Het
Hcn1 ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC 13: 118,112,269 (GRCm39) probably benign Het
Hibch T A 1: 52,940,494 (GRCm39) probably null Het
Il1rap G A 16: 26,520,001 (GRCm39) E356K probably benign Het
Itm2c G T 1: 85,822,457 (GRCm39) G25C probably benign Het
Klhl8 C T 5: 104,015,392 (GRCm39) V511I probably damaging Het
Mcee A G 7: 64,061,665 (GRCm39) H156R possibly damaging Het
Myh3 C A 11: 66,983,196 (GRCm39) Q908K probably benign Het
Ncoa7 A G 10: 30,567,725 (GRCm39) S318P probably benign Het
Nhsl1 A G 10: 18,402,487 (GRCm39) N1208D probably benign Het
Or10p21 T A 10: 128,847,766 (GRCm39) I204K possibly damaging Het
Or4a15 C T 2: 89,192,896 (GRCm39) M292I probably benign Het
P2rx7 C T 5: 122,793,096 (GRCm39) P140S probably damaging Het
Plcd4 C G 1: 74,593,660 (GRCm39) H262D probably benign Het
Prps1l1 T C 12: 35,035,140 (GRCm39) V85A probably damaging Het
Prss27 G A 17: 24,263,919 (GRCm39) V202I probably benign Het
Rtn4r A T 16: 17,969,258 (GRCm39) M229L probably benign Het
Slc43a1 A G 2: 84,690,167 (GRCm39) H491R possibly damaging Het
Slc44a2 A G 9: 21,253,481 (GRCm39) D83G probably benign Het
Spag6l A G 16: 16,580,889 (GRCm39) V486A probably damaging Het
Sspo A T 6: 48,460,436 (GRCm39) Q3408L possibly damaging Het
Tasor2 T C 13: 3,624,388 (GRCm39) D1854G probably benign Het
Tjp3 G A 10: 81,109,641 (GRCm39) T854I probably benign Het
Trim30a C T 7: 104,070,663 (GRCm39) G250D probably benign Het
Ttll1 G T 15: 83,376,783 (GRCm39) D313E probably damaging Het
Zfp160 A T 17: 21,246,350 (GRCm39) N300I probably damaging Het
Zfp458 C T 13: 67,406,190 (GRCm39) C83Y probably damaging Het
Zmym4 A T 4: 126,798,188 (GRCm39) probably null Het
Other mutations in Tmsb10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1909:Tmsb10b UTSW 7 24,561,731 (GRCm39) missense possibly damaging 0.50
R7675:Tmsb10b UTSW 7 24,561,784 (GRCm39) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- AAGGGCATGATTAGGTCTCTTGC -3'
(R):5'- TGGCAGTCCGATTAGTGGAG -3'

Sequencing Primer
(F):5'- CATGATTAGGTCTCTTGCTGCAGC -3'
(R):5'- ATTAGTGGAGGGGTCCCC -3'
Posted On 2020-07-28