Incidental Mutation 'R8305:Or10al3'
ID 641030
Institutional Source Beutler Lab
Gene Symbol Or10al3
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor family 10 subfamily AL member 3
Synonyms GA_x6K02T2PSCP-2159633-2160598, MOR263-7, Olfr119
MMRRC Submission 067716-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8305 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38007576-38012611 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38012389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 276 (M276K)
Ref Sequence ENSEMBL: ENSMUSP00000092919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483]
AlphaFold Q7TRJ5
Predicted Effect probably benign
Transcript: ENSMUST00000080483
AA Change: M276K

PolyPhen 2 Score 0.098 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: M276K

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik C T 14: 64,208,844 (GRCm39) E243K possibly damaging Het
Accsl A T 2: 93,696,423 (GRCm39) H58Q probably benign Het
Actl7a T A 4: 56,743,744 (GRCm39) F90L probably benign Het
Adam5 G A 8: 25,300,719 (GRCm39) A270V possibly damaging Het
Angptl3 A G 4: 98,919,548 (GRCm39) T103A probably damaging Het
Ankhd1 T C 18: 36,780,219 (GRCm39) L1757P possibly damaging Het
Apoa4 T A 9: 46,152,453 (GRCm39) M1K probably null Het
Arih1 T A 9: 59,303,770 (GRCm39) Q445L probably benign Het
Asb14 A T 14: 26,634,054 (GRCm39) I420L probably benign Het
Bbs2 A C 8: 94,800,953 (GRCm39) V626G probably damaging Het
Cep290 C A 10: 100,380,796 (GRCm39) A1678D probably benign Het
Cilp G A 9: 65,186,286 (GRCm39) G794S probably damaging Het
Clca3a1 C T 3: 144,464,927 (GRCm39) probably benign Het
Clca3b T A 3: 144,531,698 (GRCm39) N702I probably damaging Het
Col24a1 T C 3: 145,179,937 (GRCm39) V1143A probably benign Het
Cux1 T C 5: 136,388,863 (GRCm39) T223A probably benign Het
Defa30 A T 8: 21,625,475 (GRCm39) T80S probably benign Het
Dennd1a G A 2: 37,748,093 (GRCm39) L375F probably damaging Het
Dnajc6 C T 4: 101,480,984 (GRCm39) T675I probably damaging Het
Emc9 A G 14: 55,822,556 (GRCm39) V4A probably damaging Het
Enpp3 C G 10: 24,700,827 (GRCm39) probably null Het
Fam117b A G 1: 59,952,782 (GRCm39) T154A probably benign Het
Filip1 G T 9: 79,727,757 (GRCm39) Y287* probably null Het
Flt3 T C 5: 147,284,864 (GRCm39) D751G probably damaging Het
Frem1 T A 4: 82,918,226 (GRCm39) Q572L probably benign Het
Gja10 G A 4: 32,602,441 (GRCm39) probably benign Het
Gm39115 A G 7: 141,689,360 (GRCm39) C138R unknown Het
Gm7356 T A 17: 14,221,699 (GRCm39) Y110F probably benign Het
Igf2r T C 17: 12,952,747 (GRCm39) K233R probably benign Het
Igkv9-129 A T 6: 67,817,206 (GRCm39) E103D probably benign Het
Igsf11 C A 16: 38,827,586 (GRCm39) T48N probably damaging Het
Itpkc A T 7: 26,913,944 (GRCm39) Y506N probably damaging Het
Kat2a A C 11: 100,600,304 (GRCm39) M357R possibly damaging Het
Kbtbd12 T C 6: 88,595,132 (GRCm39) R233G possibly damaging Het
Kcnd2 T A 6: 21,726,197 (GRCm39) C563* probably null Het
Kcnu1 T C 8: 26,382,018 (GRCm39) V456A probably benign Het
Kif24 A G 4: 41,428,825 (GRCm39) V45A probably damaging Het
Macf1 A T 4: 123,289,414 (GRCm39) probably benign Het
Map3k19 T A 1: 127,745,007 (GRCm39) E1177D Het
Mdn1 G T 4: 32,725,107 (GRCm39) L2575F probably benign Het
Mga T A 2: 119,776,800 (GRCm39) M1569K possibly damaging Het
Mvk T C 5: 114,588,840 (GRCm39) Y161H probably damaging Het
Or14c44 G T 7: 86,061,987 (GRCm39) C139F probably damaging Het
Or2n1 C A 17: 38,486,464 (GRCm39) T163K probably damaging Het
Pcdhb14 T A 18: 37,583,075 (GRCm39) V727E possibly damaging Het
Pcsk7 T G 9: 45,821,707 (GRCm39) V167G probably damaging Het
Plin5 T C 17: 56,422,221 (GRCm39) D146G probably benign Het
Plxna4 C T 6: 32,188,000 (GRCm39) G879R possibly damaging Het
Prss58 C T 6: 40,872,594 (GRCm39) A171T probably benign Het
Pum1 A G 4: 130,499,231 (GRCm39) I1016V probably benign Het
Rbm43 A G 2: 51,816,712 (GRCm39) V85A probably damaging Het
Rdh16f2 T A 10: 127,712,864 (GRCm39) D287E probably damaging Het
Rptor T A 11: 119,702,812 (GRCm39) L393Q probably damaging Het
Sbf2 T G 7: 109,970,825 (GRCm39) H857P possibly damaging Het
Scn8a A C 15: 100,938,387 (GRCm39) T1919P probably benign Het
Sema6b C T 17: 56,434,084 (GRCm39) G377E probably damaging Het
Senp7 T A 16: 55,975,603 (GRCm39) D436E probably damaging Het
Slc6a17 T A 3: 107,380,901 (GRCm39) I535F probably benign Het
Sptbn2 T A 19: 4,779,158 (GRCm39) S281T possibly damaging Het
Stt3b T C 9: 115,083,999 (GRCm39) I392M probably damaging Het
Tfap2b T C 1: 19,296,660 (GRCm39) V201A possibly damaging Het
Timm10b T C 7: 105,289,876 (GRCm39) probably benign Het
Ttc23 A C 7: 67,312,135 (GRCm39) D14A probably damaging Het
Usp32 A T 11: 84,923,011 (GRCm39) L636I possibly damaging Het
Vgll4 G T 6: 114,867,613 (GRCm39) H79Q probably damaging Het
Vps13d A G 4: 144,818,858 (GRCm39) I3047T Het
Zan T C 5: 137,448,813 (GRCm39) E1680G unknown Het
Other mutations in Or10al3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02209:Or10al3 APN 17 38,011,883 (GRCm39) missense probably damaging 1.00
IGL03339:Or10al3 APN 17 38,011,682 (GRCm39) missense probably damaging 0.99
R0092:Or10al3 UTSW 17 38,011,696 (GRCm39) missense probably damaging 0.98
R0207:Or10al3 UTSW 17 38,011,949 (GRCm39) nonsense probably null
R0378:Or10al3 UTSW 17 38,011,932 (GRCm39) missense probably damaging 1.00
R0408:Or10al3 UTSW 17 38,012,190 (GRCm39) missense probably benign
R0483:Or10al3 UTSW 17 38,012,188 (GRCm39) missense probably benign 0.01
R1595:Or10al3 UTSW 17 38,012,004 (GRCm39) missense probably benign 0.03
R1901:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R1902:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R2845:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R2846:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R4356:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R4381:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R6744:Or10al3 UTSW 17 38,012,336 (GRCm39) nonsense probably null
R7674:Or10al3 UTSW 17 38,011,573 (GRCm39) missense probably benign 0.03
R7677:Or10al3 UTSW 17 38,011,957 (GRCm39) missense probably damaging 1.00
R7994:Or10al3 UTSW 17 38,012,326 (GRCm39) missense probably damaging 0.99
R8512:Or10al3 UTSW 17 38,012,071 (GRCm39) missense probably damaging 1.00
R9300:Or10al3 UTSW 17 38,011,815 (GRCm39) missense probably damaging 1.00
R9760:Or10al3 UTSW 17 38,012,434 (GRCm39) missense probably damaging 1.00
Z1177:Or10al3 UTSW 17 38,011,944 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- AGATACATCCCAAAATGAGGCTGC -3'
(R):5'- CTCATTACCCAGCAGCTCTG -3'

Sequencing Primer
(F):5'- CCAAAATGAGGCTGCAATTTTTGTGG -3'
(R):5'- AGCTCTGCAAGGTTCTGTTAC -3'
Posted On 2020-07-28