Incidental Mutation 'R8307:Or4c11c'
ID 641115
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 067717-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8307 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88661633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 57 (M57I)
Ref Sequence ENSEMBL: ENSMUSP00000075769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000076438
AA Change: M57I

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: M57I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215929
AA Change: M57I

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik C A 4: 148,025,837 (GRCm39) T119K probably benign Het
Abca13 T A 11: 9,227,922 (GRCm39) L655* probably null Het
Aifm2 A G 10: 61,562,171 (GRCm39) Y69C probably damaging Het
Atp2c1 C T 9: 105,320,030 (GRCm39) V448I probably benign Het
Barx2 A G 9: 31,770,307 (GRCm39) S74P probably damaging Het
Bod1l T C 5: 41,978,498 (GRCm39) K939E probably damaging Het
Cdh12 C A 15: 21,358,949 (GRCm39) F124L probably benign Het
Cdh12 T A 15: 21,358,950 (GRCm39) Y125N probably damaging Het
Cdx2 A G 5: 147,243,477 (GRCm39) Y106H possibly damaging Het
Chmp1a C T 8: 123,932,980 (GRCm39) G158S probably damaging Het
Cilp G A 9: 65,186,286 (GRCm39) G794S probably damaging Het
Cntnap1 A T 11: 101,079,702 (GRCm39) Y1277F possibly damaging Het
Csde1 A G 3: 102,946,389 (GRCm39) probably benign Het
Dennd4c A C 4: 86,744,109 (GRCm39) D1317A probably benign Het
Dgcr2 C T 16: 17,676,242 (GRCm39) G176D probably benign Het
Dock2 A T 11: 34,260,362 (GRCm39) M993K possibly damaging Het
Dpy19l1 G A 9: 24,414,297 (GRCm39) P44S probably benign Het
Dsg2 C T 18: 20,708,121 (GRCm39) P74L probably benign Het
Epg5 T A 18: 78,065,894 (GRCm39) F2078Y probably damaging Het
Fancl A G 11: 26,349,642 (GRCm39) probably benign Het
Fbn1 C A 2: 125,347,402 (GRCm39) R41L possibly damaging Het
Gemin5 G A 11: 58,042,420 (GRCm39) T467M probably damaging Het
Hexb T C 13: 97,330,707 (GRCm39) Q102R probably benign Het
Hmcn2 A G 2: 31,286,127 (GRCm39) D2093G probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Igkv1-131 A G 6: 67,743,051 (GRCm39) Y111H probably damaging Het
Il6st G T 13: 112,624,281 (GRCm39) G177V probably benign Het
Kank4 G A 4: 98,666,915 (GRCm39) Q511* probably null Het
Krt90 A G 15: 101,467,634 (GRCm39) L248P probably damaging Het
Krtap5-2 A G 7: 141,728,586 (GRCm39) C187R unknown Het
Lonp1 C A 17: 56,933,573 (GRCm39) A101S probably benign Het
Nckap5l A G 15: 99,321,058 (GRCm39) C1241R probably damaging Het
Or1j11 A G 2: 36,312,333 (GRCm39) T308A probably benign Het
Or6c203 T C 10: 129,010,101 (GRCm39) D263G probably benign Het
Pcdh15 T A 10: 74,342,307 (GRCm39) C1131* probably null Het
Pcdhgc3 A G 18: 37,940,847 (GRCm39) D416G probably damaging Het
Pikfyve T C 1: 65,284,894 (GRCm39) M786T possibly damaging Het
Pink1 A T 4: 138,045,273 (GRCm39) M297K probably benign Het
Pln T C 10: 53,219,975 (GRCm39) Y6H unknown Het
Ppp2r2c A G 5: 37,104,430 (GRCm39) D270G probably damaging Het
Pramel58 T G 5: 94,831,416 (GRCm39) L141R probably damaging Het
Prcd A T 11: 116,550,199 (GRCm39) T76S possibly damaging Het
Pxylp1 A G 9: 96,721,137 (GRCm39) probably null Het
Rab11fip4 A T 11: 79,581,600 (GRCm39) N532Y possibly damaging Het
Ralgapa1 C A 12: 55,788,308 (GRCm39) V592L probably damaging Het
Robo2 T C 16: 73,753,498 (GRCm39) D793G probably damaging Het
Sec14l1 G A 11: 117,034,242 (GRCm39) probably null Het
Srcap T A 7: 127,124,541 (GRCm39) V237E probably damaging Het
Srl A G 16: 4,315,009 (GRCm39) I211T probably benign Het
Tasor G T 14: 27,193,622 (GRCm39) A941S probably damaging Het
Tet3 A G 6: 83,356,909 (GRCm39) V883A probably damaging Het
Trim46 A G 3: 89,151,223 (GRCm39) Y113H probably benign Het
Trim58 G A 11: 58,537,909 (GRCm39) A267T probably benign Het
Tsks G A 7: 44,607,086 (GRCm39) G140S Het
Vmn2r110 C A 17: 20,803,319 (GRCm39) V419L probably benign Het
Vmn2r66 A G 7: 84,656,270 (GRCm39) F249L probably benign Het
Vps8 A C 16: 21,314,652 (GRCm39) D584A probably benign Het
Zfp605 T A 5: 110,276,063 (GRCm39) C394S probably damaging Het
Zscan4e A G 7: 11,041,059 (GRCm39) I271T probably benign Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTTGGACTGACACAATGCAG -3'
(R):5'- TGCAAGGGTTTACAGATGGC -3'

Sequencing Primer
(F):5'- TGCAGCAGAACAGCACTGTC -3'
(R):5'- GTTTACAGATGGCCACATAACGGTC -3'
Posted On 2020-07-28