Incidental Mutation 'R8308:Gm10188'
ID 641172
Institutional Source Beutler Lab
Gene Symbol Gm10188
Ensembl Gene ENSMUSG00000066936
Gene Name predicted gene 10188
Synonyms
MMRRC Submission 067793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R8308 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 132156786-132157505 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 132157310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 19 (V19I)
Ref Sequence ENSEMBL: ENSMUSP00000083731 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086544] [ENSMUST00000112357] [ENSMUST00000185436] [ENSMUST00000187339] [ENSMUST00000188169] [ENSMUST00000191418]
AlphaFold Q3V432
Predicted Effect unknown
Transcript: ENSMUST00000086544
AA Change: V19I
SMART Domains Protein: ENSMUSP00000083731
Gene: ENSMUSG00000066936
AA Change: V19I

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112357
SMART Domains Protein: ENSMUSP00000107976
Gene: ENSMUSG00000079330

DomainStartEndE-ValueType
Pfam:LEM 3 42 9.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185436
SMART Domains Protein: ENSMUSP00000140418
Gene: ENSMUSG00000079330

DomainStartEndE-ValueType
LEM 2 45 1.1e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187339
SMART Domains Protein: ENSMUSP00000139708
Gene: ENSMUSG00000079330

DomainStartEndE-ValueType
LEM 2 45 1.1e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188169
SMART Domains Protein: ENSMUSP00000140524
Gene: ENSMUSG00000079330

DomainStartEndE-ValueType
LEM 2 45 1.1e-9 SMART
low complexity region 81 100 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191418
SMART Domains Protein: ENSMUSP00000140193
Gene: ENSMUSG00000079330

DomainStartEndE-ValueType
LEM 2 45 1.1e-9 SMART
low complexity region 81 92 N/A INTRINSIC
transmembrane domain 174 196 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 A G 3: 59,659,570 (GRCm39) D341G probably damaging Het
Abca17 T C 17: 24,486,657 (GRCm39) T1457A probably damaging Het
Acot8 A T 2: 164,646,663 (GRCm39) S25R probably benign Het
Ap2a2 T C 7: 141,210,212 (GRCm39) V850A probably benign Het
Baiap2l1 T A 5: 144,214,487 (GRCm39) E402D probably benign Het
Bptf T C 11: 106,943,815 (GRCm39) K2689E probably damaging Het
Cdh22 C A 2: 164,954,098 (GRCm39) D808Y probably damaging Het
Cilp G A 9: 65,186,286 (GRCm39) G794S probably damaging Het
Cipc A G 12: 87,008,809 (GRCm39) T223A probably benign Het
Crem G T 18: 3,295,397 (GRCm39) T57K possibly damaging Het
Cyp17a1 T A 19: 46,656,516 (GRCm39) I393F probably benign Het
Dgcr2 C T 16: 17,676,242 (GRCm39) G176D probably benign Het
Dock3 C A 9: 106,790,371 (GRCm39) V1451L probably benign Het
Dsg2 C T 18: 20,708,121 (GRCm39) P74L probably benign Het
Ece1 T C 4: 137,664,075 (GRCm39) V224A probably damaging Het
Flg A T 3: 93,190,586 (GRCm39) S152C unknown Het
Gcsam A T 16: 45,430,902 (GRCm39) N3I probably damaging Het
Gpr27 T C 6: 99,670,217 (GRCm39) L193P probably damaging Het
Grin2b A T 6: 135,900,074 (GRCm39) V269E probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Kif14 A G 1: 136,443,651 (GRCm39) I1275V possibly damaging Het
Krt27 T C 11: 99,239,862 (GRCm39) E234G probably benign Het
Lmo7 T C 14: 102,139,807 (GRCm39) probably null Het
Matk T G 10: 81,094,121 (GRCm39) S18A probably benign Het
Mbd3l1 A G 9: 18,395,886 (GRCm39) T4A probably benign Het
Mettl23 G A 11: 116,739,185 (GRCm39) probably null Het
Ncam1 A T 9: 49,479,817 (GRCm39) W54R probably damaging Het
Olfm5 A G 7: 103,803,606 (GRCm39) Y286H probably damaging Het
Or10d5j T A 9: 39,868,265 (GRCm39) M1L probably benign Het
Or4c11c G A 2: 88,661,633 (GRCm39) M57I possibly damaging Het
Or4q3 T C 14: 50,582,922 (GRCm39) I326V probably benign Het
Or5ac15 C T 16: 58,939,899 (GRCm39) C178Y probably damaging Het
Pmch A G 10: 87,927,614 (GRCm39) Y105C probably damaging Het
Prg3 A G 2: 84,819,676 (GRCm39) T57A probably benign Het
Ptpn13 A G 5: 103,688,838 (GRCm39) E877G probably damaging Het
Ptprt A G 2: 161,769,566 (GRCm39) V433A probably benign Het
Rufy1 A T 11: 50,297,233 (GRCm39) D406E probably benign Het
Scara5 C T 14: 65,927,234 (GRCm39) R44W probably damaging Het
Scg2 T G 1: 79,414,576 (GRCm39) K49T probably benign Het
Slc40a1 A G 1: 45,950,180 (GRCm39) I424T probably benign Het
Slc4a8 T A 15: 100,693,735 (GRCm39) S479T probably damaging Het
Sorl1 T C 9: 41,929,456 (GRCm39) D1139G probably damaging Het
Srcap A G 7: 127,152,353 (GRCm39) I2206V possibly damaging Het
Tpk1 T C 6: 43,642,711 (GRCm39) E9G probably benign Het
Ttn C T 2: 76,642,645 (GRCm39) V13297I possibly damaging Het
Uchl3 T C 14: 101,932,655 (GRCm39) probably null Het
Usp12 T C 5: 146,688,751 (GRCm39) D201G probably damaging Het
Vmn1r193 C T 13: 22,403,146 (GRCm39) R282H probably benign Het
Vmn2r104 T C 17: 20,261,040 (GRCm39) D461G possibly damaging Het
Zfp131 A G 13: 120,244,440 (GRCm39) M80T possibly damaging Het
Zfp457 A G 13: 67,441,663 (GRCm39) L304P probably benign Het
Zswim3 A G 2: 164,663,566 (GRCm39) E682G probably damaging Het
Other mutations in Gm10188
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02493:Gm10188 APN 1 132,157,143 (GRCm39) nonsense probably null
IGL02894:Gm10188 APN 1 132,157,037 (GRCm39) intron probably benign
R5878:Gm10188 UTSW 1 132,156,940 (GRCm39) intron probably benign
R9598:Gm10188 UTSW 1 132,157,033 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GAGCTCTGCTTTGCCTCAAAC -3'
(R):5'- GGCTTGGTTCACATTCTGTCCAG -3'

Sequencing Primer
(F):5'- TGCCTCAAACTGATACATTTCAC -3'
(R):5'- ACACGGGTGGCCCTCATTAG -3'
Posted On 2020-07-28