|Institutional Source||Beutler Lab|
|Gene Name||methyl-CpG binding domain protein 3-like 1|
|Synonyms||Mbd3l, 1700070G05Rik, 1700095H13Rik|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8308 (G1)|
|Chromosomal Location||18478359-18485298 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 18484590 bp|
|Amino Acid Change||Threonine to Alanine at position 4 (T4A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000063957 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000069218]|
|Predicted Effect||probably benign
AA Change: T4A
PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
AA Change: T4A
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mbd3l1||
(F):5'- CAAGTTGTGGGAGAGCTTTGAC -3'
(R):5'- TTGTTCTGGCTTCTCCAAGG -3'
(F):5'- CCTTGATGTTTCTGAATACAGGTC -3'
(R):5'- AAGGTCTCCTCCCACTGATAG -3'