Incidental Mutation 'R8308:Or5ac15'
ID 641217
Institutional Source Beutler Lab
Gene Symbol Or5ac15
Ensembl Gene ENSMUSG00000063020
Gene Name olfactory receptor family 5 subfamily AC member 15
Synonyms MOR182-13, MOR182-7P, GA_x54KRFPKG5P-55348161-55347241, Olfr194
MMRRC Submission 067793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R8308 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 58939511-58940431 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 58939899 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 178 (C178Y)
Ref Sequence ENSEMBL: ENSMUSP00000072407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072608]
AlphaFold L7N1Y8
Predicted Effect probably damaging
Transcript: ENSMUST00000072608
AA Change: C178Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072407
Gene: ENSMUSG00000063020
AA Change: C178Y

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 1.9e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 A G 3: 59,659,570 (GRCm39) D341G probably damaging Het
Abca17 T C 17: 24,486,657 (GRCm39) T1457A probably damaging Het
Acot8 A T 2: 164,646,663 (GRCm39) S25R probably benign Het
Ap2a2 T C 7: 141,210,212 (GRCm39) V850A probably benign Het
Baiap2l1 T A 5: 144,214,487 (GRCm39) E402D probably benign Het
Bptf T C 11: 106,943,815 (GRCm39) K2689E probably damaging Het
Cdh22 C A 2: 164,954,098 (GRCm39) D808Y probably damaging Het
Cilp G A 9: 65,186,286 (GRCm39) G794S probably damaging Het
Cipc A G 12: 87,008,809 (GRCm39) T223A probably benign Het
Crem G T 18: 3,295,397 (GRCm39) T57K possibly damaging Het
Cyp17a1 T A 19: 46,656,516 (GRCm39) I393F probably benign Het
Dgcr2 C T 16: 17,676,242 (GRCm39) G176D probably benign Het
Dock3 C A 9: 106,790,371 (GRCm39) V1451L probably benign Het
Dsg2 C T 18: 20,708,121 (GRCm39) P74L probably benign Het
Ece1 T C 4: 137,664,075 (GRCm39) V224A probably damaging Het
Flg A T 3: 93,190,586 (GRCm39) S152C unknown Het
Gcsam A T 16: 45,430,902 (GRCm39) N3I probably damaging Het
Gm10188 C T 1: 132,157,310 (GRCm39) V19I unknown Het
Gpr27 T C 6: 99,670,217 (GRCm39) L193P probably damaging Het
Grin2b A T 6: 135,900,074 (GRCm39) V269E probably damaging Het
Hmmr G A 11: 40,612,499 (GRCm39) S206F probably damaging Het
Kif14 A G 1: 136,443,651 (GRCm39) I1275V possibly damaging Het
Krt27 T C 11: 99,239,862 (GRCm39) E234G probably benign Het
Lmo7 T C 14: 102,139,807 (GRCm39) probably null Het
Matk T G 10: 81,094,121 (GRCm39) S18A probably benign Het
Mbd3l1 A G 9: 18,395,886 (GRCm39) T4A probably benign Het
Mettl23 G A 11: 116,739,185 (GRCm39) probably null Het
Ncam1 A T 9: 49,479,817 (GRCm39) W54R probably damaging Het
Olfm5 A G 7: 103,803,606 (GRCm39) Y286H probably damaging Het
Or10d5j T A 9: 39,868,265 (GRCm39) M1L probably benign Het
Or4c11c G A 2: 88,661,633 (GRCm39) M57I possibly damaging Het
Or4q3 T C 14: 50,582,922 (GRCm39) I326V probably benign Het
Pmch A G 10: 87,927,614 (GRCm39) Y105C probably damaging Het
Prg3 A G 2: 84,819,676 (GRCm39) T57A probably benign Het
Ptpn13 A G 5: 103,688,838 (GRCm39) E877G probably damaging Het
Ptprt A G 2: 161,769,566 (GRCm39) V433A probably benign Het
Rufy1 A T 11: 50,297,233 (GRCm39) D406E probably benign Het
Scara5 C T 14: 65,927,234 (GRCm39) R44W probably damaging Het
Scg2 T G 1: 79,414,576 (GRCm39) K49T probably benign Het
Slc40a1 A G 1: 45,950,180 (GRCm39) I424T probably benign Het
Slc4a8 T A 15: 100,693,735 (GRCm39) S479T probably damaging Het
Sorl1 T C 9: 41,929,456 (GRCm39) D1139G probably damaging Het
Srcap A G 7: 127,152,353 (GRCm39) I2206V possibly damaging Het
Tpk1 T C 6: 43,642,711 (GRCm39) E9G probably benign Het
Ttn C T 2: 76,642,645 (GRCm39) V13297I possibly damaging Het
Uchl3 T C 14: 101,932,655 (GRCm39) probably null Het
Usp12 T C 5: 146,688,751 (GRCm39) D201G probably damaging Het
Vmn1r193 C T 13: 22,403,146 (GRCm39) R282H probably benign Het
Vmn2r104 T C 17: 20,261,040 (GRCm39) D461G possibly damaging Het
Zfp131 A G 13: 120,244,440 (GRCm39) M80T possibly damaging Het
Zfp457 A G 13: 67,441,663 (GRCm39) L304P probably benign Het
Zswim3 A G 2: 164,663,566 (GRCm39) E682G probably damaging Het
Other mutations in Or5ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01807:Or5ac15 APN 16 58,939,936 (GRCm39) missense possibly damaging 0.94
IGL02098:Or5ac15 APN 16 58,940,433 (GRCm39) utr 5 prime probably benign
IGL02276:Or5ac15 APN 16 58,940,378 (GRCm39) missense probably benign 0.01
IGL03122:Or5ac15 APN 16 58,939,801 (GRCm39) missense probably benign 0.00
R0781:Or5ac15 UTSW 16 58,940,187 (GRCm39) missense probably damaging 0.97
R1162:Or5ac15 UTSW 16 58,939,735 (GRCm39) missense probably damaging 0.99
R1526:Or5ac15 UTSW 16 58,940,293 (GRCm39) missense probably damaging 1.00
R1654:Or5ac15 UTSW 16 58,940,052 (GRCm39) missense possibly damaging 0.50
R4379:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R4380:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R5768:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5771:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5942:Or5ac15 UTSW 16 58,940,039 (GRCm39) nonsense probably null
R6131:Or5ac15 UTSW 16 58,940,256 (GRCm39) missense probably damaging 1.00
R6539:Or5ac15 UTSW 16 58,940,114 (GRCm39) missense probably damaging 0.99
R6621:Or5ac15 UTSW 16 58,940,287 (GRCm39) missense probably benign 0.19
R7642:Or5ac15 UTSW 16 58,940,011 (GRCm39) missense possibly damaging 0.94
R8863:Or5ac15 UTSW 16 58,939,712 (GRCm39) nonsense probably null
RF009:Or5ac15 UTSW 16 58,940,274 (GRCm39) missense probably damaging 0.99
Z1177:Or5ac15 UTSW 16 58,939,735 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCAGGTGGAGAAGGCTTTTC -3'
(R):5'- TGCAACTACAGAATGTTTCCTTCTG -3'

Sequencing Primer
(F):5'- CTTCTGCCCCTCTCAGACTTTG -3'
(R):5'- ATGGCCTATGACCGCTATGTAGC -3'
Posted On 2020-07-28