Incidental Mutation 'R8309:Rnase13'
ID 641288
Institutional Source Beutler Lab
Gene Symbol Rnase13
Ensembl Gene ENSMUSG00000068392
Gene Name ribonuclease, RNase A family, 13 (non-active)
Synonyms
MMRRC Submission 067794-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R8309 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 52158819-52160230 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 52159893 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 82 (I82N)
Ref Sequence ENSEMBL: ENSMUSP00000087203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008957] [ENSMUST00000089771] [ENSMUST00000177625]
AlphaFold Q5GAM7
Predicted Effect probably benign
Transcript: ENSMUST00000008957
SMART Domains Protein: ENSMUSP00000008957
Gene: ENSMUSG00000008813

DomainStartEndE-ValueType
Pfam:p25-alpha 6 167 1.6e-73 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000089771
AA Change: I82N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000087203
Gene: ENSMUSG00000068392
AA Change: I82N

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:RnaseA 27 149 1.9e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177625
SMART Domains Protein: ENSMUSP00000136454
Gene: ENSMUSG00000008813

DomainStartEndE-ValueType
Pfam:p25-alpha 5 169 5.9e-57 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (82/82)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik T A 2: 35,279,599 (GRCm39) Y34F possibly damaging Het
Abcb6 A T 1: 75,149,588 (GRCm39) S664T probably benign Het
Abcc4 C T 14: 118,853,804 (GRCm39) V443M probably damaging Het
Abhd2 G A 7: 78,998,095 (GRCm39) G209D probably damaging Het
Acte1 A G 7: 143,437,680 (GRCm39) N126S possibly damaging Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Apbb2 T A 5: 66,520,179 (GRCm39) M449L probably benign Het
Ccdc81 T A 7: 89,526,786 (GRCm39) probably null Het
Cd209b A T 8: 3,976,559 (GRCm39) C42* probably null Het
Cdhr18 G A 14: 13,814,954 (GRCm38) Q860* probably null Het
Clec18a A T 8: 111,808,689 (GRCm39) M11K probably benign Het
Clock A T 5: 76,402,269 (GRCm39) S130R probably benign Het
Col12a1 G A 9: 79,512,465 (GRCm39) A2910V possibly damaging Het
Col6a4 C T 9: 105,952,414 (GRCm39) A495T probably benign Het
Cyp4f37 A T 17: 32,853,952 (GRCm39) N467I probably damaging Het
Ddo G A 10: 40,513,375 (GRCm39) V106M possibly damaging Het
Dennd5a A G 7: 109,500,332 (GRCm39) L931P probably damaging Het
Dgcr6 A G 16: 17,884,598 (GRCm39) D82G probably damaging Het
Dnah7b T C 1: 46,179,032 (GRCm39) S902P probably damaging Het
Dnal4 T G 15: 79,646,711 (GRCm39) I57L probably benign Het
Dst T A 1: 34,156,592 (GRCm39) I174N probably damaging Het
Dync2i1 T C 12: 116,219,705 (GRCm39) E79G probably damaging Het
Dync2i2 A G 2: 29,922,201 (GRCm39) L420P probably damaging Het
Eeig2 G A 3: 108,934,658 (GRCm39) probably benign Het
Efhb T C 17: 53,756,563 (GRCm39) T363A probably damaging Het
Ehbp1l1 A G 19: 5,767,103 (GRCm39) F1245S probably damaging Het
Eif4g1 A G 16: 20,507,578 (GRCm39) D1453G probably benign Het
Fbp1 T C 13: 63,016,831 (GRCm39) I224V probably benign Het
Gm10782 T G 13: 56,510,948 (GRCm39) F79V noncoding transcript Het
Gpaa1 C G 15: 76,216,160 (GRCm39) R47G possibly damaging Het
Hs2st1 G A 3: 144,143,365 (GRCm39) S226L possibly damaging Het
Hydin A G 8: 111,334,534 (GRCm39) Y4992C probably benign Het
Ikbke A T 1: 131,191,065 (GRCm39) C549* probably null Het
Insrr G A 3: 87,717,749 (GRCm39) G817S probably benign Het
Itgb5 G A 16: 33,685,923 (GRCm39) V88I probably benign Het
Krt78 A G 15: 101,854,922 (GRCm39) V963A probably benign Het
Lars1 T C 18: 42,376,093 (GRCm39) Y239C possibly damaging Het
Map2k5 A G 9: 63,246,361 (GRCm39) probably null Het
Mfn2 A T 4: 147,974,693 (GRCm39) W118R probably benign Het
Mga T A 2: 119,791,411 (GRCm39) I2550N probably damaging Het
Mgam A G 6: 40,722,111 (GRCm39) I401V possibly damaging Het
Mrps18c A G 5: 100,952,264 (GRCm39) Y141C probably damaging Het
Myo1e A T 9: 70,254,045 (GRCm39) I565L possibly damaging Het
Nfatc4 G A 14: 56,063,848 (GRCm39) E112K probably damaging Het
Nubp1 A G 16: 10,239,486 (GRCm39) M255V probably benign Het
Or13n4 A C 7: 106,423,620 (GRCm39) S38A probably benign Het
Or52a33 A G 7: 103,288,658 (GRCm39) S230P probably damaging Het
Or8g33 C T 9: 39,337,966 (GRCm39) V134I probably benign Het
Pask A T 1: 93,240,573 (GRCm39) C1264* probably null Het
Pcgf2 T C 11: 97,582,569 (GRCm39) T173A probably benign Het
Plcg1 T C 2: 160,595,853 (GRCm39) I574T probably benign Het
Plin4 T C 17: 56,411,437 (GRCm39) T865A probably damaging Het
Pnpt1 T C 11: 29,103,277 (GRCm39) V514A probably benign Het
Ppp1r3a T A 6: 14,719,700 (GRCm39) I405F probably benign Het
Qpctl A G 7: 18,882,398 (GRCm39) V86A probably benign Het
Rab3gap1 G T 1: 127,837,655 (GRCm39) W239L possibly damaging Het
Ralgapa2 T A 2: 146,246,786 (GRCm39) T939S possibly damaging Het
Rapgef2 G T 3: 78,990,509 (GRCm39) T923N possibly damaging Het
Rit2 T A 18: 31,286,898 (GRCm39) I96F probably damaging Het
Rp1 C A 1: 4,417,312 (GRCm39) V1267L probably benign Het
Serpinb9b G A 13: 33,223,554 (GRCm39) E249K probably damaging Het
Serpinb9c G T 13: 33,334,094 (GRCm39) T344K possibly damaging Het
Serpinh1 T C 7: 98,998,151 (GRCm39) I160V possibly damaging Het
Sipa1 A G 19: 5,704,964 (GRCm39) S544P probably damaging Het
Slc17a5 A T 9: 78,478,311 (GRCm39) Y231* probably null Het
Srcap T C 7: 127,148,529 (GRCm39) V1959A probably damaging Het
Srrm4 G A 5: 116,729,626 (GRCm39) probably benign Het
Stat1 T C 1: 52,190,404 (GRCm39) I553T possibly damaging Het
Stpg1 A G 4: 135,256,903 (GRCm39) I231M probably benign Het
Szt2 G GC 4: 118,232,679 (GRCm39) probably null Het
Trpv3 C T 11: 73,170,747 (GRCm39) T209M probably damaging Het
Tsc22d2 G T 3: 58,324,544 (GRCm39) G479C unknown Het
Ttc3 A G 16: 94,267,838 (GRCm39) H1950R probably damaging Het
Tusc3 A G 8: 39,617,882 (GRCm39) *348W probably null Het
Utp4 A T 8: 107,642,853 (GRCm39) T504S probably benign Het
Vmn1r15 A G 6: 57,235,635 (GRCm39) M168V probably benign Het
Wdsub1 C T 2: 59,704,578 (GRCm39) probably benign Het
Xrcc5 T A 1: 72,358,286 (GRCm39) M207K possibly damaging Het
Zc3h7a A T 16: 10,964,417 (GRCm39) probably benign Het
Zdbf2 T A 1: 63,345,750 (GRCm39) N1376K possibly damaging Het
Zfp558 A C 9: 18,368,213 (GRCm39) S192A probably benign Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Zfp964 A G 8: 70,115,924 (GRCm39) T175A possibly damaging Het
Zfp988 A G 4: 147,416,765 (GRCm39) R400G probably damaging Het
Other mutations in Rnase13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01859:Rnase13 APN 14 52,159,760 (GRCm39) missense probably damaging 1.00
PIT1430001:Rnase13 UTSW 14 52,159,987 (GRCm39) missense probably damaging 1.00
R4902:Rnase13 UTSW 14 52,160,052 (GRCm39) missense probably benign 0.03
R6019:Rnase13 UTSW 14 52,159,860 (GRCm39) missense probably damaging 1.00
R8142:Rnase13 UTSW 14 52,159,893 (GRCm39) missense probably damaging 1.00
R8264:Rnase13 UTSW 14 52,159,914 (GRCm39) missense probably damaging 0.99
R8885:Rnase13 UTSW 14 52,159,940 (GRCm39) nonsense probably null
R9502:Rnase13 UTSW 14 52,159,825 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TCCCTAGTAGAGACCAATGATACC -3'
(R):5'- CAGGCATCACAATTCAGACGG -3'

Sequencing Primer
(F):5'- TGATACCTATAGGCTCAGCATCATGC -3'
(R):5'- TTCAGACGGCCATCAAGAACTTC -3'
Posted On 2020-07-28