Incidental Mutation 'R0100:Tex22'
ID 64137
Institutional Source Beutler Lab
Gene Symbol Tex22
Ensembl Gene ENSMUSG00000012211
Gene Name testis expressed gene 22
Synonyms Tep22, 1700028O09Rik
MMRRC Submission 038386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R0100 (G1)
Quality Score 158
Status Validated
Chromosome 12
Chromosomal Location 113038122-113052537 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 113052392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 150 (I150N)
Ref Sequence ENSEMBL: ENSMUSP00000116272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012355] [ENSMUST00000109729] [ENSMUST00000146107]
AlphaFold Q9D9U4
Predicted Effect probably benign
Transcript: ENSMUST00000012355
AA Change: I150N

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000012355
Gene: ENSMUSG00000012211
AA Change: I150N

DomainStartEndE-ValueType
low complexity region 14 24 N/A INTRINSIC
low complexity region 103 120 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109729
AA Change: I150N

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000105351
Gene: ENSMUSG00000012211
AA Change: I150N

DomainStartEndE-ValueType
low complexity region 14 24 N/A INTRINSIC
low complexity region 103 120 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000146107
AA Change: I150N

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000116272
Gene: ENSMUSG00000012211
AA Change: I150N

DomainStartEndE-ValueType
low complexity region 14 24 N/A INTRINSIC
low complexity region 103 120 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,259,415 (GRCm39) C814R probably damaging Het
Bbof1 T A 12: 84,457,829 (GRCm39) D31E probably benign Het
Ccdc51 C T 9: 108,921,066 (GRCm39) Q318* probably null Het
Cpxm2 T A 7: 131,656,600 (GRCm39) H554L possibly damaging Het
Dbr1 T A 9: 99,465,722 (GRCm39) D433E probably benign Het
Ddx55 C T 5: 124,694,845 (GRCm39) T91I probably damaging Het
Dhx57 T C 17: 80,582,585 (GRCm39) D340G possibly damaging Het
Dnah1 C T 14: 30,984,109 (GRCm39) probably null Het
Dpp9 C T 17: 56,512,854 (GRCm39) G118D possibly damaging Het
Fam81a C T 9: 70,010,091 (GRCm39) probably benign Het
Fat4 A C 3: 39,034,397 (GRCm39) N2683T probably damaging Het
Fbxo47 C T 11: 97,759,432 (GRCm39) G165S probably damaging Het
Garre1 A G 7: 33,953,436 (GRCm39) I442T possibly damaging Het
Gpatch2 C A 1: 186,958,014 (GRCm39) A123E probably damaging Het
Greb1 T A 12: 16,730,225 (GRCm39) Q1734L probably benign Het
Gtf2ird2 T C 5: 134,245,857 (GRCm39) L705P probably damaging Het
H13 T A 2: 152,531,783 (GRCm39) probably null Het
Hip1 T C 5: 135,465,307 (GRCm39) D367G probably benign Het
Ift140 C T 17: 25,309,928 (GRCm39) Q1112* probably null Het
Il17b A G 18: 61,823,342 (GRCm39) M59V probably benign Het
Lpin3 T C 2: 160,747,260 (GRCm39) Y829H probably damaging Het
Mocs3 C T 2: 168,073,110 (GRCm39) R186C probably damaging Het
Or10al5 T C 17: 38,063,594 (GRCm39) F283S probably benign Het
Or2bd2 C T 7: 6,443,399 (GRCm39) R167C probably damaging Het
Or4c120 T A 2: 89,001,431 (GRCm39) I42F probably benign Het
Or5be3 T C 2: 86,863,939 (GRCm39) T209A probably benign Het
Osgepl1 A G 1: 53,362,372 (GRCm39) I405V probably damaging Het
Pdcd11 T C 19: 47,091,105 (GRCm39) S360P probably benign Het
Plekhs1 A G 19: 56,466,934 (GRCm39) E255G probably damaging Het
Tmem106a T C 11: 101,477,084 (GRCm39) S98P probably benign Het
Tnfrsf18 A G 4: 156,112,823 (GRCm39) T170A probably benign Het
Trpc6 C T 9: 8,653,035 (GRCm39) P614S probably damaging Het
Usp28 C A 9: 48,947,232 (GRCm39) P566Q probably damaging Het
Washc5 A G 15: 59,215,947 (GRCm39) F811L possibly damaging Het
Other mutations in Tex22
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0100:Tex22 UTSW 12 113,052,392 (GRCm39) missense probably benign 0.15
R0766:Tex22 UTSW 12 113,052,143 (GRCm39) missense possibly damaging 0.94
R1497:Tex22 UTSW 12 113,039,000 (GRCm39) missense probably benign 0.00
R4761:Tex22 UTSW 12 113,052,386 (GRCm39) missense possibly damaging 0.54
R5013:Tex22 UTSW 12 113,052,104 (GRCm39) missense probably damaging 0.97
R7859:Tex22 UTSW 12 113,052,103 (GRCm39) missense possibly damaging 0.92
R8221:Tex22 UTSW 12 113,038,696 (GRCm39) splice site probably null
R9732:Tex22 UTSW 12 113,052,196 (GRCm39) missense possibly damaging 0.94
Z1177:Tex22 UTSW 12 113,052,239 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGAAGTCGCTGGAACATCAGCATC -3'
(R):5'- AGACCTGAGACCTTTGTCCTGACC -3'

Sequencing Primer
(F):5'- GGACAGACACAGCCAGG -3'
(R):5'- CTCTGTGGGAGGGTCAAGAC -3'
Posted On 2013-08-06