Incidental Mutation 'R8311:Wdr37'
ID 641396
Institutional Source Beutler Lab
Gene Symbol Wdr37
Ensembl Gene ENSMUSG00000021147
Gene Name WD repeat domain 37
Synonyms 4933417A01Rik, 3110035P10Rik
MMRRC Submission 067796-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8311 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 8853004-8921945 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 8903609 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 165 (R165G)
Ref Sequence ENSEMBL: ENSMUSP00000135742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021572] [ENSMUST00000054251] [ENSMUST00000164183] [ENSMUST00000175958] [ENSMUST00000176098] [ENSMUST00000176329] [ENSMUST00000176922] [ENSMUST00000176587] [ENSMUST00000176715] [ENSMUST00000176813]
AlphaFold Q8CBE3
Predicted Effect probably benign
Transcript: ENSMUST00000021572
SMART Domains Protein: ENSMUSP00000021572
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000054251
SMART Domains Protein: ENSMUSP00000062174
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000164183
AA Change: R165G
SMART Domains Protein: ENSMUSP00000131469
Gene: ENSMUSG00000021147
AA Change: R165G

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000175958
Predicted Effect probably benign
Transcript: ENSMUST00000176098
SMART Domains Protein: ENSMUSP00000135094
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 19 58 4.27e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176329
SMART Domains Protein: ENSMUSP00000135101
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 100 140 9.75e-3 SMART
WD40 143 182 4.27e-8 SMART
Predicted Effect unknown
Transcript: ENSMUST00000176922
AA Change: R165G
SMART Domains Protein: ENSMUSP00000135742
Gene: ENSMUSG00000021147
AA Change: R165G

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176429
SMART Domains Protein: ENSMUSP00000134916
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 26 66 9.75e-3 SMART
WD40 69 113 3.81e-5 SMART
WD40 118 156 2.38e-6 SMART
Blast:WD40 160 193 2e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000176587
SMART Domains Protein: ENSMUSP00000135271
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 62 100 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176715
Predicted Effect probably benign
Transcript: ENSMUST00000176813
SMART Domains Protein: ENSMUSP00000135097
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
SCOP:d1ijqa1 128 180 3e-4 SMART
Blast:WD40 145 180 5e-19 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,184,815 (GRCm39) probably benign Het
4930407I10Rik T C 15: 81,947,440 (GRCm39) W446R possibly damaging Het
Aldh1l2 T A 10: 83,326,479 (GRCm39) E912D probably damaging Het
Apol9a T C 15: 77,289,220 (GRCm39) D49G possibly damaging Het
Bnc2 A T 4: 84,194,582 (GRCm39) D847E possibly damaging Het
Ccdc91 A G 6: 147,437,114 (GRCm39) N100S possibly damaging Het
Copb2 G T 9: 98,450,072 (GRCm39) K10N possibly damaging Het
Cyp4a14 A G 4: 115,348,275 (GRCm39) S401P probably damaging Het
Cyp4f15 A T 17: 32,916,914 (GRCm39) Q277L probably benign Het
Dmxl2 A T 9: 54,354,217 (GRCm39) S410T probably benign Het
Dnah9 T C 11: 65,880,644 (GRCm39) N2651S probably benign Het
Efhb A G 17: 53,720,489 (GRCm39) probably null Het
Eif4ebp1 T A 8: 27,765,124 (GRCm39) F113L probably damaging Het
Emilin2 C G 17: 71,562,141 (GRCm39) D954H probably damaging Het
Eng A G 2: 32,569,005 (GRCm39) T511A probably benign Het
Eps8l1 A G 7: 4,474,817 (GRCm39) D266G probably damaging Het
Fam120a T C 13: 49,087,433 (GRCm39) H309R possibly damaging Het
Gga3 A T 11: 115,477,834 (GRCm39) S585T probably benign Het
Gm12117 T C 11: 33,226,126 (GRCm39) Q70R probably damaging Het
Gpr158 A G 2: 21,373,701 (GRCm39) H212R probably benign Het
Hmgb1 A G 5: 148,987,427 (GRCm39) F41L possibly damaging Het
Iqcm T A 8: 76,480,118 (GRCm39) probably benign Het
Itgav T A 2: 83,596,121 (GRCm39) I214N probably damaging Het
Kcna1 T A 6: 126,619,255 (GRCm39) H355L probably benign Het
Lrrc37a C T 11: 103,394,247 (GRCm39) V393I probably benign Het
Mak16 T C 8: 31,658,697 (GRCm39) D4G probably damaging Het
Metap2 C T 10: 93,697,384 (GRCm39) R432H possibly damaging Het
Nlrc4 G A 17: 74,753,540 (GRCm39) T281M probably damaging Het
Ntrk1 T A 3: 87,688,870 (GRCm39) Q561L probably damaging Het
Or10ak7 A C 4: 118,791,347 (GRCm39) S231A probably damaging Het
Or10w3 A G 19: 13,704,035 (GRCm39) T137A possibly damaging Het
Pira1 T C 7: 3,739,482 (GRCm39) D462G probably benign Het
Polr2a T C 11: 69,628,282 (GRCm39) I1304V probably null Het
Ppp4r2 T C 6: 100,843,343 (GRCm39) S354P probably benign Het
Ptchd3 A G 11: 121,727,299 (GRCm39) H391R possibly damaging Het
Rchy1 T C 5: 92,099,762 (GRCm39) D192G probably damaging Het
Rmdn1 T C 4: 19,575,329 (GRCm39) probably null Het
Rp1 T A 1: 4,418,572 (GRCm39) I847L probably benign Het
Rtn1 T C 12: 72,350,838 (GRCm39) E457G probably damaging Het
Serpind1 G A 16: 17,160,730 (GRCm39) S420N possibly damaging Het
Sirpa T C 2: 129,458,143 (GRCm39) V253A probably damaging Het
Snapc4 A T 2: 26,268,546 (GRCm39) F38L probably benign Het
Spata31g1 T C 4: 42,973,169 (GRCm39) V834A probably benign Het
Srcap T C 7: 127,156,969 (GRCm39) F2321S probably damaging Het
Stat4 A T 1: 52,142,075 (GRCm39) I641F probably damaging Het
Tmem216 A T 19: 10,529,191 (GRCm39) F65Y probably benign Het
Tmem37 C T 1: 119,995,982 (GRCm39) V32M possibly damaging Het
Tmprss11c T G 5: 86,383,412 (GRCm39) Q338P probably damaging Het
Tonsl C T 15: 76,517,463 (GRCm39) S752N probably benign Het
Vmn1r26 T C 6: 57,985,518 (GRCm39) K224E probably benign Het
Vps13b T A 15: 35,887,100 (GRCm39) V3229D probably benign Het
Vwa5b2 C T 16: 20,409,972 (GRCm39) R21W probably damaging Het
Yars2 T C 16: 16,125,147 (GRCm39) F388L probably benign Het
Ykt6 T A 11: 5,912,366 (GRCm39) D106E probably benign Het
Zc3h12a A C 4: 125,020,788 (GRCm39) S18R possibly damaging Het
Other mutations in Wdr37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Wdr37 APN 13 8,870,541 (GRCm39) missense probably damaging 1.00
IGL00753:Wdr37 APN 13 8,911,210 (GRCm39) missense probably damaging 1.00
IGL02479:Wdr37 APN 13 8,892,820 (GRCm39) missense probably damaging 1.00
profound UTSW 13 8,892,764 (GRCm39) critical splice donor site probably null
radical UTSW 13 8,897,710 (GRCm39) splice site probably null
R0885:Wdr37 UTSW 13 8,885,288 (GRCm39) splice site probably null
R1073:Wdr37 UTSW 13 8,855,876 (GRCm39) missense probably damaging 0.99
R1085:Wdr37 UTSW 13 8,855,964 (GRCm39) missense probably damaging 1.00
R1537:Wdr37 UTSW 13 8,887,039 (GRCm39) missense probably benign 0.01
R1538:Wdr37 UTSW 13 8,886,828 (GRCm39) missense probably benign
R1541:Wdr37 UTSW 13 8,870,574 (GRCm39) missense probably benign 0.26
R1868:Wdr37 UTSW 13 8,886,887 (GRCm39) missense probably damaging 1.00
R2240:Wdr37 UTSW 13 8,911,268 (GRCm39) start gained probably benign
R3815:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R3817:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R3818:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R3819:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R4721:Wdr37 UTSW 13 8,904,065 (GRCm39) missense possibly damaging 0.89
R5080:Wdr37 UTSW 13 8,897,710 (GRCm39) splice site probably null
R6297:Wdr37 UTSW 13 8,892,764 (GRCm39) critical splice donor site probably null
R6761:Wdr37 UTSW 13 8,899,684 (GRCm39) missense probably benign 0.07
R7505:Wdr37 UTSW 13 8,869,971 (GRCm39) missense probably damaging 1.00
R7840:Wdr37 UTSW 13 8,886,911 (GRCm39) missense probably damaging 0.96
R7873:Wdr37 UTSW 13 8,855,969 (GRCm39) missense probably damaging 0.99
R8081:Wdr37 UTSW 13 8,885,406 (GRCm39) missense probably damaging 1.00
R9030:Wdr37 UTSW 13 8,885,424 (GRCm39) missense probably damaging 1.00
R9452:Wdr37 UTSW 13 8,897,663 (GRCm39) missense
R9736:Wdr37 UTSW 13 8,911,136 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCAGATAGAACTTTGAGCCC -3'
(R):5'- TCTTCCACAGCCAGTCACAG -3'

Sequencing Primer
(F):5'- GAACTTTGAGCCCACATATTTAGCC -3'
(R):5'- GTACCAGTCAGCTTTCTCAGAAG -3'
Posted On 2020-07-28