Incidental Mutation 'R8312:Insrr'
| ID |
641421 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Insrr
|
| Ensembl Gene |
ENSMUSG00000005640 |
| Gene Name |
insulin receptor-related receptor |
| Synonyms |
|
| MMRRC Submission |
067718-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.241)
|
| Stock # |
R8312 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
87796951-87816101 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 87800484 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Glutamic Acid
at position 78
(Q78E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000029711
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029711]
[ENSMUST00000029714]
[ENSMUST00000090981]
[ENSMUST00000107582]
|
| AlphaFold |
Q9WTL4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000029711
AA Change: Q78E
PolyPhen 2
Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000029711
Gene: ENSMUSG00000005640
AA Change: Q78E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
1.8e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
3.8e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029714
|
| SMART Domains |
Protein: ENSMUSP00000029714
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090981
|
| SMART Domains |
Protein: ENSMUSP00000088503
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107582
AA Change: Q78E
PolyPhen 2
Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000103208
Gene: ENSMUSG00000005640
AA Change: Q78E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
7.7e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
1.6e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Meta Mutation Damage Score |
0.3833 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (68/68) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcd4 |
T |
C |
12: 84,615,416 (GRCm38) |
R23G |
probably damaging |
Het |
| Abraxas2 |
A |
G |
7: 132,876,600 (GRCm38) |
Y163C |
probably damaging |
Het |
| Acnat1 |
A |
T |
4: 49,449,142 (GRCm38) |
L208* |
probably null |
Het |
| Agbl5 |
A |
G |
5: 30,894,506 (GRCm38) |
E556G |
probably damaging |
Het |
| Ampd2 |
C |
A |
3: 108,080,116 (GRCm38) |
V134L |
probably benign |
Het |
| Arih2 |
A |
G |
9: 108,644,274 (GRCm38) |
S2P |
probably damaging |
Het |
| C87436 |
T |
A |
6: 86,457,831 (GRCm38) |
L387Q |
probably damaging |
Het |
| Card9 |
A |
T |
2: 26,357,789 (GRCm38) |
Y183* |
probably null |
Het |
| Cdk14 |
T |
C |
5: 4,894,141 (GRCm38) |
D394G |
probably benign |
Het |
| Cep135 |
C |
T |
5: 76,636,899 (GRCm38) |
S947L |
probably damaging |
Het |
| Cfb |
T |
C |
17: 34,858,145 (GRCm38) |
K505E |
probably benign |
Het |
| Cnot4 |
T |
A |
6: 35,023,141 (GRCm38) |
D708V |
probably damaging |
Het |
| Col16a1 |
T |
A |
4: 130,054,451 (GRCm38) |
L281M |
unknown |
Het |
| Col6a3 |
G |
T |
1: 90,813,690 (GRCm38) |
D673E |
possibly damaging |
Het |
| Ctdnep1 |
G |
A |
11: 69,988,701 (GRCm38) |
S150N |
probably benign |
Het |
| Fanca |
T |
A |
8: 123,269,810 (GRCm38) |
|
probably benign |
Het |
| Fras1 |
T |
A |
5: 96,588,191 (GRCm38) |
N548K |
probably benign |
Het |
| Gbp2b |
C |
A |
3: 142,599,054 (GRCm38) |
P84T |
probably damaging |
Het |
| Gbp2b |
A |
G |
3: 142,599,051 (GRCm38) |
M83V |
probably benign |
Het |
| Gli2 |
A |
T |
1: 118,868,112 (GRCm38) |
|
probably benign |
Het |
| Greb1l |
A |
G |
18: 10,511,587 (GRCm38) |
|
probably benign |
Het |
| Grn |
A |
C |
11: 102,436,247 (GRCm38) |
K557T |
probably damaging |
Het |
| Hapln1 |
C |
T |
13: 89,601,444 (GRCm38) |
A36V |
probably benign |
Het |
| Heg1 |
C |
T |
16: 33,726,675 (GRCm38) |
R635W |
probably benign |
Het |
| Hivep1 |
C |
A |
13: 42,155,177 (GRCm38) |
Q298K |
possibly damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,738,764 (GRCm38) |
I1297T |
probably damaging |
Het |
| Hp1bp3 |
T |
A |
4: 138,223,439 (GRCm38) |
|
probably benign |
Het |
| Htr4 |
C |
G |
18: 62,437,478 (GRCm38) |
F201L |
probably damaging |
Het |
| Itga6 |
A |
T |
2: 71,855,953 (GRCm38) |
M1072L |
probably benign |
Het |
| Kdsr |
A |
G |
1: 106,747,486 (GRCm38) |
|
probably null |
Het |
| Klhl7 |
T |
C |
5: 24,134,967 (GRCm38) |
I149T |
probably damaging |
Het |
| Lce1l |
G |
C |
3: 92,850,459 (GRCm38) |
P31A |
unknown |
Het |
| Mag |
T |
C |
7: 30,911,469 (GRCm38) |
Y116C |
probably damaging |
Het |
| Mast2 |
A |
G |
4: 116,430,486 (GRCm38) |
S131P |
probably benign |
Het |
| Mlec |
C |
A |
5: 115,150,207 (GRCm38) |
|
probably null |
Het |
| Mrap2 |
G |
A |
9: 87,169,659 (GRCm38) |
|
probably null |
Het |
| Myo5b |
A |
G |
18: 74,733,962 (GRCm38) |
K1395E |
probably damaging |
Het |
| Nipa2 |
G |
A |
7: 55,933,302 (GRCm38) |
Q232* |
probably null |
Het |
| Nsd3 |
C |
T |
8: 25,663,252 (GRCm38) |
T536M |
probably damaging |
Het |
| Oit3 |
T |
C |
10: 59,438,810 (GRCm38) |
N56S |
probably benign |
Het |
| Olfr155 |
A |
T |
4: 43,854,461 (GRCm38) |
I51F |
probably benign |
Het |
| Olfr165 |
T |
C |
16: 19,407,237 (GRCm38) |
M260V |
probably benign |
Het |
| Olfr9 |
A |
G |
10: 128,990,478 (GRCm38) |
T189A |
probably benign |
Het |
| Pax3 |
C |
T |
1: 78,195,369 (GRCm38) |
R68Q |
probably damaging |
Het |
| Pcnx2 |
G |
T |
8: 125,762,850 (GRCm38) |
H1668Q |
possibly damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm38) |
|
probably benign |
Het |
| Pkd1 |
A |
G |
17: 24,567,128 (GRCm38) |
S463G |
probably benign |
Het |
| Plb1 |
C |
T |
5: 32,328,485 (GRCm38) |
T871M |
probably damaging |
Het |
| Prdx1 |
A |
G |
4: 116,699,201 (GRCm38) |
D182G |
possibly damaging |
Het |
| Prkch |
T |
A |
12: 73,760,584 (GRCm38) |
F593I |
noncoding transcript |
Het |
| Psrc1 |
C |
T |
3: 108,386,357 (GRCm38) |
P194L |
probably benign |
Het |
| Ptp4a2 |
A |
T |
4: 129,839,634 (GRCm38) |
I18L |
probably benign |
Het |
| Samd10 |
A |
T |
2: 181,596,875 (GRCm38) |
L153H |
probably damaging |
Het |
| Shc3 |
T |
G |
13: 51,442,718 (GRCm38) |
H423P |
probably damaging |
Het |
| Siae |
A |
T |
9: 37,646,297 (GRCm38) |
I467F |
|
Het |
| Slc27a5 |
C |
T |
7: 12,991,287 (GRCm38) |
R411Q |
probably damaging |
Het |
| Spata24 |
A |
G |
18: 35,660,808 (GRCm38) |
I56T |
probably benign |
Het |
| Spns3 |
G |
A |
11: 72,499,708 (GRCm38) |
T407M |
probably damaging |
Het |
| Spta1 |
G |
A |
1: 174,240,211 (GRCm38) |
C2068Y |
probably damaging |
Het |
| Svs2 |
C |
A |
2: 164,238,171 (GRCm38) |
G25W |
probably damaging |
Het |
| Thsd7a |
T |
C |
6: 12,471,182 (GRCm38) |
D479G |
|
Het |
| Trhde |
T |
C |
10: 114,413,287 (GRCm38) |
Y858C |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,951,648 (GRCm38) |
R1057C |
unknown |
Het |
| Tulp4 |
G |
T |
17: 6,207,058 (GRCm38) |
|
probably null |
Het |
| Tyk2 |
T |
C |
9: 21,115,649 (GRCm38) |
T613A |
possibly damaging |
Het |
| Ugt2b37 |
T |
C |
5: 87,242,940 (GRCm38) |
K356R |
probably benign |
Het |
| Vmn1r39 |
A |
G |
6: 66,804,857 (GRCm38) |
V159A |
noncoding transcript |
Het |
| Vps35 |
A |
G |
8: 85,274,869 (GRCm38) |
V440A |
possibly damaging |
Het |
| Zmym6 |
A |
G |
4: 127,123,834 (GRCm38) |
N1136S |
probably damaging |
Het |
|
| Other mutations in Insrr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00718:Insrr
|
APN |
3 |
87,813,674 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL00801:Insrr
|
APN |
3 |
87,813,808 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01628:Insrr
|
APN |
3 |
87,800,792 (GRCm38) |
nonsense |
probably null |
|
|
IGL01755:Insrr
|
APN |
3 |
87,814,186 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02100:Insrr
|
APN |
3 |
87,811,620 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02261:Insrr
|
APN |
3 |
87,800,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02366:Insrr
|
APN |
3 |
87,809,909 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL02387:Insrr
|
APN |
3 |
87,813,127 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02478:Insrr
|
APN |
3 |
87,809,412 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL02550:Insrr
|
APN |
3 |
87,804,498 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02555:Insrr
|
APN |
3 |
87,813,817 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02673:Insrr
|
APN |
3 |
87,813,061 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02724:Insrr
|
APN |
3 |
87,809,572 (GRCm38) |
missense |
probably benign |
0.31 |
|
IGL02798:Insrr
|
APN |
3 |
87,810,517 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02969:Insrr
|
APN |
3 |
87,814,191 (GRCm38) |
nonsense |
probably null |
|
|
IGL03073:Insrr
|
APN |
3 |
87,809,938 (GRCm38) |
splice site |
probably benign |
|
|
IGL03178:Insrr
|
APN |
3 |
87,802,541 (GRCm38) |
splice site |
probably null |
|
|
IGL03389:Insrr
|
APN |
3 |
87,808,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03399:Insrr
|
APN |
3 |
87,809,331 (GRCm38) |
missense |
probably null |
0.99 |
|
IGL02799:Insrr
|
UTSW |
3 |
87,813,581 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0011:Insrr
|
UTSW |
3 |
87,809,616 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0053:Insrr
|
UTSW |
3 |
87,800,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0053:Insrr
|
UTSW |
3 |
87,800,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0357:Insrr
|
UTSW |
3 |
87,808,646 (GRCm38) |
splice site |
probably null |
|
|
R0501:Insrr
|
UTSW |
3 |
87,810,684 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0504:Insrr
|
UTSW |
3 |
87,813,156 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R0522:Insrr
|
UTSW |
3 |
87,800,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0555:Insrr
|
UTSW |
3 |
87,814,437 (GRCm38) |
splice site |
probably benign |
|
|
R0558:Insrr
|
UTSW |
3 |
87,810,981 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R0599:Insrr
|
UTSW |
3 |
87,813,133 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1312:Insrr
|
UTSW |
3 |
87,800,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1694:Insrr
|
UTSW |
3 |
87,804,062 (GRCm38) |
missense |
probably benign |
|
|
R1785:Insrr
|
UTSW |
3 |
87,810,572 (GRCm38) |
splice site |
probably null |
|
|
R1786:Insrr
|
UTSW |
3 |
87,810,572 (GRCm38) |
splice site |
probably null |
|
|
R1892:Insrr
|
UTSW |
3 |
87,813,877 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1950:Insrr
|
UTSW |
3 |
87,814,513 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2080:Insrr
|
UTSW |
3 |
87,814,291 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R2094:Insrr
|
UTSW |
3 |
87,803,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2130:Insrr
|
UTSW |
3 |
87,810,572 (GRCm38) |
splice site |
probably null |
|
|
R2131:Insrr
|
UTSW |
3 |
87,810,572 (GRCm38) |
splice site |
probably null |
|
|
R2133:Insrr
|
UTSW |
3 |
87,810,572 (GRCm38) |
splice site |
probably null |
|
|
R2220:Insrr
|
UTSW |
3 |
87,809,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2259:Insrr
|
UTSW |
3 |
87,800,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2404:Insrr
|
UTSW |
3 |
87,802,667 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R4027:Insrr
|
UTSW |
3 |
87,809,599 (GRCm38) |
missense |
probably benign |
|
|
R4042:Insrr
|
UTSW |
3 |
87,813,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4510:Insrr
|
UTSW |
3 |
87,808,671 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4511:Insrr
|
UTSW |
3 |
87,808,671 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4571:Insrr
|
UTSW |
3 |
87,800,887 (GRCm38) |
missense |
probably benign |
|
|
R4870:Insrr
|
UTSW |
3 |
87,811,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5057:Insrr
|
UTSW |
3 |
87,815,265 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5393:Insrr
|
UTSW |
3 |
87,810,700 (GRCm38) |
splice site |
probably null |
|
|
R5685:Insrr
|
UTSW |
3 |
87,800,496 (GRCm38) |
splice site |
probably null |
|
|
R6039:Insrr
|
UTSW |
3 |
87,809,301 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R6039:Insrr
|
UTSW |
3 |
87,809,301 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R6047:Insrr
|
UTSW |
3 |
87,804,176 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6276:Insrr
|
UTSW |
3 |
87,800,519 (GRCm38) |
nonsense |
probably null |
|
|
R6298:Insrr
|
UTSW |
3 |
87,812,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6726:Insrr
|
UTSW |
3 |
87,813,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6727:Insrr
|
UTSW |
3 |
87,813,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6728:Insrr
|
UTSW |
3 |
87,813,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6796:Insrr
|
UTSW |
3 |
87,813,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7041:Insrr
|
UTSW |
3 |
87,815,244 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7169:Insrr
|
UTSW |
3 |
87,808,594 (GRCm38) |
missense |
probably benign |
0.15 |
|
R7270:Insrr
|
UTSW |
3 |
87,803,133 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7340:Insrr
|
UTSW |
3 |
87,814,316 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7398:Insrr
|
UTSW |
3 |
87,808,732 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7473:Insrr
|
UTSW |
3 |
87,804,531 (GRCm38) |
splice site |
probably null |
|
|
R7815:Insrr
|
UTSW |
3 |
87,808,695 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8159:Insrr
|
UTSW |
3 |
87,800,428 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8289:Insrr
|
UTSW |
3 |
87,814,194 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8309:Insrr
|
UTSW |
3 |
87,810,442 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8445:Insrr
|
UTSW |
3 |
87,813,584 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8917:Insrr
|
UTSW |
3 |
87,810,969 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8960:Insrr
|
UTSW |
3 |
87,813,079 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8989:Insrr
|
UTSW |
3 |
87,815,357 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9015:Insrr
|
UTSW |
3 |
87,813,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9202:Insrr
|
UTSW |
3 |
87,813,120 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9251:Insrr
|
UTSW |
3 |
87,810,084 (GRCm38) |
missense |
probably benign |
0.08 |
|
R9327:Insrr
|
UTSW |
3 |
87,814,297 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9646:Insrr
|
UTSW |
3 |
87,814,498 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF022:Insrr
|
UTSW |
3 |
87,804,485 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
Z1177:Insrr
|
UTSW |
3 |
87,800,827 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
Z1192:Insrr
|
UTSW |
3 |
87,802,579 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGCTCTTGGTCTGCACTG -3'
(R):5'- ATGGCAAAGTTCCTGGTTCTTC -3'
Sequencing Primer
(F):5'- AGGCTCTTGGTCTGCACTGTATTC -3'
(R):5'- TTCTCCACACGCACGGC -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation