Incidental Mutation 'R0104:Zfp655'
| ID |
64147 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp655
|
| Ensembl Gene |
ENSMUSG00000007812 |
| Gene Name |
zinc finger protein 655 |
| Synonyms |
2700038I16Rik, 9030409O18Rik |
| MMRRC Submission |
038390-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.451)
|
| Stock # |
R0104 (G1)
|
| Quality Score |
98 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
145168525-145184112 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 145180825 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 228
(S228P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128969
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167316]
[ENSMUST00000199322]
|
| AlphaFold |
Q9CZP3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167316
AA Change: S228P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000128969
Gene: ENSMUSG00000007812
AA Change: S228P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
243 |
265 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
299 |
328 |
1.38e2 |
SMART |
|
ZnF_C2H2
|
334 |
356 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
3.99e0 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
1.01e-1 |
SMART |
|
low complexity region
|
463 |
475 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
517 |
6.47e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199322
|
| Meta Mutation Damage Score |
0.2478 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 17 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Dnah5 |
A |
T |
15: 28,453,499 (GRCm39) |
E4423D |
possibly damaging |
Het |
| Fsip2 |
A |
T |
2: 82,809,317 (GRCm39) |
T1879S |
possibly damaging |
Het |
| Gm136 |
G |
T |
4: 34,746,593 (GRCm39) |
H139Q |
possibly damaging |
Het |
| Ifrd2 |
T |
A |
9: 107,465,116 (GRCm39) |
L10H |
probably damaging |
Het |
| Itpr3 |
C |
A |
17: 27,314,966 (GRCm39) |
H704Q |
probably benign |
Het |
| Kcng1 |
A |
G |
2: 168,110,966 (GRCm39) |
I66T |
probably damaging |
Het |
| Kcnv2 |
T |
C |
19: 27,300,619 (GRCm39) |
Y157H |
probably damaging |
Het |
| Leng8 |
A |
G |
7: 4,146,807 (GRCm39) |
D443G |
probably damaging |
Het |
| Mlst8 |
T |
C |
17: 24,695,091 (GRCm39) |
N264S |
possibly damaging |
Het |
| Pcdhb8 |
A |
G |
18: 37,488,718 (GRCm39) |
E132G |
probably benign |
Het |
| Pmpcb |
C |
G |
5: 21,951,036 (GRCm39) |
S266* |
probably null |
Het |
| Prmt7 |
T |
C |
8: 106,963,982 (GRCm39) |
I292T |
probably damaging |
Het |
| Rif1 |
T |
C |
2: 52,000,104 (GRCm39) |
L1186S |
possibly damaging |
Het |
| Sox30 |
A |
C |
11: 45,872,141 (GRCm39) |
E332A |
possibly damaging |
Het |
| Taf2 |
T |
C |
15: 54,901,734 (GRCm39) |
D820G |
probably benign |
Het |
| Tas2r120 |
T |
A |
6: 132,634,809 (GRCm39) |
|
probably null |
Het |
| Zfyve9 |
C |
A |
4: 108,575,360 (GRCm39) |
D574Y |
probably damaging |
Het |
|
| Other mutations in Zfp655 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Zfp655
|
APN |
5 |
145,180,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01679:Zfp655
|
APN |
5 |
145,180,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02379:Zfp655
|
APN |
5 |
145,180,765 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02647:Zfp655
|
APN |
5 |
145,179,816 (GRCm39) |
missense |
probably benign |
|
|
R0104:Zfp655
|
UTSW |
5 |
145,180,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Zfp655
|
UTSW |
5 |
145,181,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zfp655
|
UTSW |
5 |
145,180,867 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1528:Zfp655
|
UTSW |
5 |
145,181,411 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2076:Zfp655
|
UTSW |
5 |
145,181,410 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2119:Zfp655
|
UTSW |
5 |
145,181,594 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2375:Zfp655
|
UTSW |
5 |
145,181,206 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2403:Zfp655
|
UTSW |
5 |
145,181,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4032:Zfp655
|
UTSW |
5 |
145,180,858 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4532:Zfp655
|
UTSW |
5 |
145,181,507 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4880:Zfp655
|
UTSW |
5 |
145,181,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5484:Zfp655
|
UTSW |
5 |
145,180,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5529:Zfp655
|
UTSW |
5 |
145,181,546 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6193:Zfp655
|
UTSW |
5 |
145,181,586 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6195:Zfp655
|
UTSW |
5 |
145,180,572 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7050:Zfp655
|
UTSW |
5 |
145,181,545 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7471:Zfp655
|
UTSW |
5 |
145,181,542 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7612:Zfp655
|
UTSW |
5 |
145,173,999 (GRCm39) |
missense |
unknown |
|
|
R7626:Zfp655
|
UTSW |
5 |
145,173,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7989:Zfp655
|
UTSW |
5 |
145,181,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8557:Zfp655
|
UTSW |
5 |
145,180,835 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8805:Zfp655
|
UTSW |
5 |
145,181,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Zfp655
|
UTSW |
5 |
145,181,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9664:Zfp655
|
UTSW |
5 |
145,180,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp655
|
UTSW |
5 |
145,180,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCAAGTTCCTGAAACCAGAGAGG -3'
(R):5'- TGCATCACAGGACTTATCAGACGC -3'
Sequencing Primer
(F):5'- TCAGCAAGAAGACTTTCAGCAG -3'
(R):5'- tgtaggatttctctctggtgtg -3'
|
| Posted On |
2013-08-06 |
Incidental Mutation