Incidental Mutation 'R8313:Zmym4'
| ID |
641488 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmym4
|
| Ensembl Gene |
ENSMUSG00000042446 |
| Gene Name |
zinc finger, MYM-type 4 |
| Synonyms |
Zfp262, 6330503C17Rik |
| MMRRC Submission |
067797-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.586)
|
| Stock # |
R8313 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 126804762 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Tyrosine
at position 464
(H464Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
| AlphaFold |
A2A791 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106108
AA Change: H464Y
PolyPhen 2
Score 0.191 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: H464Y
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
|
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
|
TRASH
|
441 |
479 |
1.77e0 |
SMART |
|
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
|
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
|
TRASH
|
579 |
615 |
2.82e1 |
SMART |
|
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
|
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
|
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
|
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
|
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
|
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: H212Y
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
|
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
|
TRASH
|
190 |
228 |
1.77e0 |
SMART |
|
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
|
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
|
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
|
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
|
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
|
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
|
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alkal2 |
G |
T |
12: 30,934,850 (GRCm39) |
G23V |
probably damaging |
Het |
| Atl2 |
C |
T |
17: 80,160,033 (GRCm39) |
W518* |
probably null |
Het |
| Atp13a2 |
G |
A |
4: 140,730,046 (GRCm39) |
V646I |
probably benign |
Het |
| Bcar1 |
A |
T |
8: 112,440,270 (GRCm39) |
F575I |
probably benign |
Het |
| Bpifa6 |
T |
A |
2: 153,831,178 (GRCm39) |
L248* |
probably null |
Het |
| Ccdc38 |
T |
C |
10: 93,399,111 (GRCm39) |
L193P |
probably damaging |
Het |
| Ch25h |
A |
C |
19: 34,452,138 (GRCm39) |
I130S |
probably benign |
Het |
| Chaf1a |
C |
A |
17: 56,351,109 (GRCm39) |
Q30K |
unknown |
Het |
| Dab2ip |
T |
C |
2: 35,617,440 (GRCm39) |
L1106S |
probably damaging |
Het |
| Dnah3 |
A |
G |
7: 119,550,375 (GRCm39) |
Y3315H |
probably benign |
Het |
| Dnah7b |
G |
A |
1: 46,214,456 (GRCm39) |
V1074I |
possibly damaging |
Het |
| Efemp1 |
A |
G |
11: 28,860,691 (GRCm39) |
Q200R |
probably benign |
Het |
| Eif1ad3 |
A |
T |
12: 87,843,764 (GRCm39) |
D137V |
unknown |
Het |
| Epx |
C |
T |
11: 87,763,557 (GRCm39) |
R221Q |
possibly damaging |
Het |
| Exosc7 |
T |
C |
9: 122,956,942 (GRCm39) |
L109P |
probably damaging |
Het |
| Fbxo22 |
T |
A |
9: 55,128,344 (GRCm39) |
F222I |
probably damaging |
Het |
| Fcgbp |
A |
G |
7: 27,785,769 (GRCm39) |
D402G |
probably benign |
Het |
| Foxr1 |
A |
G |
9: 44,347,351 (GRCm39) |
V62A |
probably damaging |
Het |
| Gm8267 |
A |
T |
14: 44,961,515 (GRCm39) |
H59Q |
probably damaging |
Het |
| Gnptab |
T |
A |
10: 88,275,071 (GRCm39) |
Y1090N |
probably damaging |
Het |
| Gpr20 |
A |
G |
15: 73,568,161 (GRCm39) |
F76S |
probably damaging |
Het |
| Gpr33 |
A |
G |
12: 52,070,907 (GRCm39) |
V44A |
probably benign |
Het |
| Grin3a |
G |
A |
4: 49,665,599 (GRCm39) |
T1012I |
probably benign |
Het |
| Itga1 |
T |
A |
13: 115,103,120 (GRCm39) |
T1104S |
probably benign |
Het |
| Kidins220 |
T |
A |
12: 25,054,110 (GRCm39) |
Y537N |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,057,515 (GRCm39) |
T530A |
|
Het |
| Lysmd2 |
A |
T |
9: 75,533,040 (GRCm39) |
|
probably benign |
Het |
| Mdk |
T |
C |
2: 91,761,178 (GRCm39) |
K128E |
unknown |
Het |
| Mphosph8 |
AC |
A |
14: 56,916,062 (GRCm39) |
|
probably null |
Het |
| Muc16 |
A |
C |
9: 18,436,443 (GRCm39) |
L7915W |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,753,423 (GRCm38) |
T1100S |
probably benign |
Het |
| Mxra7 |
T |
C |
11: 116,695,376 (GRCm39) |
Y176C |
probably damaging |
Het |
| Myh15 |
C |
A |
16: 48,940,381 (GRCm39) |
T777N |
probably damaging |
Het |
| Myo18b |
A |
G |
5: 113,023,045 (GRCm39) |
S116P |
unknown |
Het |
| Noc3l |
A |
G |
19: 38,784,254 (GRCm39) |
L543P |
probably damaging |
Het |
| Or5h24 |
C |
T |
16: 58,919,004 (GRCm39) |
G117D |
unknown |
Het |
| Or7a39 |
C |
T |
10: 78,715,170 (GRCm39) |
P55S |
probably benign |
Het |
| Or8c10 |
T |
A |
9: 38,279,346 (GRCm39) |
V168E |
probably damaging |
Het |
| Pkm |
G |
T |
9: 59,575,902 (GRCm39) |
R106L |
probably benign |
Het |
| Prkab2 |
G |
T |
3: 97,570,911 (GRCm39) |
V112F |
probably benign |
Het |
| Prkaca |
A |
T |
8: 84,717,151 (GRCm39) |
N172Y |
probably damaging |
Het |
| Prmt8 |
A |
G |
6: 127,666,813 (GRCm39) |
V387A |
probably benign |
Het |
| Rad17 |
T |
C |
13: 100,761,074 (GRCm39) |
T485A |
probably benign |
Het |
| Rita1 |
G |
T |
5: 120,747,716 (GRCm39) |
T194K |
possibly damaging |
Het |
| Rogdi |
C |
A |
16: 4,831,313 (GRCm39) |
|
probably benign |
Het |
| Senp5 |
T |
C |
16: 31,808,117 (GRCm39) |
D379G |
probably benign |
Het |
| Slc4a4 |
A |
G |
5: 89,194,122 (GRCm39) |
K201E |
possibly damaging |
Het |
| Slc9a4 |
C |
T |
1: 40,619,520 (GRCm39) |
|
probably benign |
Het |
| Tmem175 |
T |
A |
5: 108,791,075 (GRCm39) |
S208R |
probably benign |
Het |
| Tmem237 |
A |
T |
1: 59,147,237 (GRCm39) |
Y299N |
probably damaging |
Het |
| Tnrc6a |
T |
A |
7: 122,769,936 (GRCm39) |
N575K |
possibly damaging |
Het |
| Trak2 |
A |
T |
1: 58,960,306 (GRCm39) |
C232* |
probably null |
Het |
| Ubr3 |
A |
G |
2: 69,775,478 (GRCm39) |
H589R |
probably damaging |
Het |
| Vcp |
T |
C |
4: 42,988,728 (GRCm39) |
T249A |
possibly damaging |
Het |
| Vmn1r208 |
G |
C |
13: 22,956,947 (GRCm39) |
I183M |
probably benign |
Het |
| Vmn1r231 |
C |
T |
17: 21,110,289 (GRCm39) |
V209I |
probably benign |
Het |
| Vmn1r80 |
T |
C |
7: 11,926,994 (GRCm39) |
F35L |
probably benign |
Het |
| Vmn2r58 |
A |
T |
7: 41,521,952 (GRCm39) |
I48N |
probably benign |
Het |
| Vstm2a |
T |
A |
11: 16,231,898 (GRCm39) |
V231E |
probably damaging |
Het |
| Zfp108 |
A |
C |
7: 23,960,087 (GRCm39) |
Y226S |
possibly damaging |
Het |
| Zfp445 |
A |
T |
9: 122,682,695 (GRCm39) |
N415K |
possibly damaging |
Het |
| Zfp938 |
T |
G |
10: 82,061,422 (GRCm39) |
R399S |
possibly damaging |
Het |
|
| Other mutations in Zmym4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
|
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTTCAACTCCCCTGAAATG -3'
(R):5'- TTCAACCAAATGCAGCATGTG -3'
Sequencing Primer
(F):5'- ACCTGCTTGTATGAGGTGACACAC -3'
(R):5'- CATGTGCCAGAAGAACGCTGTC -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation