Incidental Mutation 'R8314:Kif18b'
ID641583
Institutional Source Beutler Lab
Gene Symbol Kif18b
Ensembl Gene ENSMUSG00000051378
Gene Namekinesin family member 18B
Synonyms3000004C01Rik, N-8 kinesin
MMRRC Submission
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #R8314 (G1)
Quality Score225.009
Status Not validated
Chromosome11
Chromosomal Location102905529-102925124 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 102913074 bp
ZygosityHeterozygous
Amino Acid Change Serine to Leucine at position 420 (S420L)
Ref Sequence ENSEMBL: ENSMUSP00000021311 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021311]
Predicted Effect probably benign
Transcript: ENSMUST00000021311
AA Change: S420L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000021311
Gene: ENSMUSG00000051378
AA Change: S420L

DomainStartEndE-ValueType
KISc 7 361 1.47e-158 SMART
coiled coil region 368 404 N/A INTRINSIC
low complexity region 510 522 N/A INTRINSIC
low complexity region 676 682 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T A 9: 122,948,928 T84S probably benign Het
4921501E09Rik C A 17: 33,067,064 A255S probably benign Het
4930533K18Rik A G 10: 70,875,276 T76A noncoding transcript Het
Adgrl1 C T 8: 83,938,389 T1235I probably damaging Het
Ak4 C T 4: 101,463,585 T197M possibly damaging Het
Alox12e T C 11: 70,316,172 M603V possibly damaging Het
Ap3d1 A T 10: 80,723,539 I267N possibly damaging Het
Arhgef2 T A 3: 88,621,293 I12N probably benign Het
Asnsd1 A T 1: 53,346,655 M520K probably damaging Het
B3galt5 T C 16: 96,315,449 L94P probably damaging Het
Birc3 T C 9: 7,872,941 probably benign Het
Cd177 T C 7: 24,750,588 S541G probably benign Het
Cdh8 T C 8: 99,171,379 D434G probably damaging Het
Cdkn3 A T 14: 46,769,873 silent Het
Ciita A T 16: 10,510,988 R379W probably damaging Het
Cntrl T A 2: 35,175,143 M2153K probably benign Het
Csmd1 A T 8: 16,158,244 D1232E probably benign Het
Cyp4a30b A C 4: 115,458,338 H252P probably benign Het
Dad1 G A 14: 54,253,812 R11W probably damaging Het
Ddit3 A G 10: 127,295,721 probably null Het
Dusp22 G A 13: 30,708,931 probably benign Het
Dzank1 A G 2: 144,502,958 L293P probably damaging Het
Edf1 A G 2: 25,557,965 D5G probably damaging Het
Ep400 T A 5: 110,755,753 M327L unknown Het
Fam135a A T 1: 24,021,921 H1341Q possibly damaging Het
Fam150b G T 12: 30,884,851 G23V probably damaging Het
Fam189b T C 3: 89,188,146 probably null Het
Fbxl3 C T 14: 103,089,440 V169I probably benign Het
Gm4787 A G 12: 81,379,135 L83P probably damaging Het
Habp4 A G 13: 64,184,751 E392G probably damaging Het
Hspg2 C A 4: 137,539,675 P1997Q probably benign Het
Ints9 T C 14: 65,029,030 S444P probably damaging Het
Klhl17 T A 4: 156,234,013 M51L probably benign Het
Kmt2b C T 7: 30,578,922 E1555K probably damaging Het
Malrd1 T A 2: 15,752,832 D972E unknown Het
Mapk8ip3 A T 17: 24,901,774 S805R probably benign Het
Mmp13 G A 9: 7,272,931 C97Y probably damaging Het
Moxd1 T A 10: 24,252,540 N163K possibly damaging Het
Nbea T C 3: 56,009,251 I863V probably damaging Het
Nectin4 A G 1: 171,384,727 T298A probably benign Het
Net1 T C 13: 3,912,672 probably benign Het
Ntn1 T C 11: 68,385,624 D166G probably damaging Het
Olfr1137 A G 2: 87,711,202 F235L probably benign Het
Olfr140 T C 2: 90,052,097 T76A probably benign Het
Olfr391-ps T G 11: 73,799,742 N5T noncoding transcript Het
Olfr620 T C 7: 103,612,047 Q102R probably damaging Het
Olfr948 A G 9: 39,319,305 F103S probably damaging Het
Opa3 C A 7: 19,245,015 A135E possibly damaging Het
Osbpl5 T C 7: 143,695,096 I608V probably benign Het
Phc1 A C 6: 122,320,978 S782R unknown Het
Pip5k1b T A 19: 24,355,199 T374S probably benign Het
Prkaa1 A G 15: 5,178,873 S541G probably damaging Het
Ptpn20 A G 14: 33,622,547 N143D possibly damaging Het
Rabep1 A G 11: 70,893,660 D207G possibly damaging Het
Rbbp8 G A 18: 11,720,625 M296I probably benign Het
Recql4 C A 15: 76,710,180 R46L probably damaging Het
Scgb2b18 T C 7: 33,173,157 I74M probably benign Het
Shc4 A G 2: 125,655,616 I391T possibly damaging Het
Slc38a4 A G 15: 97,010,309 F184L probably benign Het
Slc7a6 A G 8: 106,168,958 probably benign Het
Smim13 G T 13: 41,272,634 G49* probably null Het
Tbc1d19 A G 5: 53,897,047 D459G probably damaging Het
Tnpo1 T C 13: 98,884,625 N82S possibly damaging Het
Tpp2 G A 1: 43,934,227 V47I probably benign Het
Umodl1 G T 17: 30,984,832 A540S probably damaging Het
Vmn2r83 G A 10: 79,481,479 V519I possibly damaging Het
Zfp641 T C 15: 98,290,583 I139V probably damaging Het
Zfyve21 A T 12: 111,823,281 I60F probably benign Het
Other mutations in Kif18b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:Kif18b APN 11 102914675 missense probably damaging 0.99
IGL01570:Kif18b APN 11 102912391 missense probably benign 0.04
IGL02965:Kif18b APN 11 102916512 start gained probably benign
IGL02997:Kif18b APN 11 102909084 missense probably damaging 1.00
IGL03135:Kif18b APN 11 102914260 missense probably damaging 1.00
IGL02988:Kif18b UTSW 11 102908320 missense probably damaging 1.00
R0541:Kif18b UTSW 11 102915175 missense probably damaging 0.98
R1446:Kif18b UTSW 11 102914699 missense probably damaging 0.99
R1674:Kif18b UTSW 11 102913060 missense probably benign 0.04
R1729:Kif18b UTSW 11 102915541 critical splice donor site probably null
R1784:Kif18b UTSW 11 102915541 critical splice donor site probably null
R2249:Kif18b UTSW 11 102912388 missense probably benign 0.01
R2291:Kif18b UTSW 11 102908270 missense probably damaging 1.00
R3723:Kif18b UTSW 11 102916276 missense probably damaging 1.00
R5496:Kif18b UTSW 11 102913742 missense possibly damaging 0.88
R5500:Kif18b UTSW 11 102915700 missense probably damaging 1.00
R5598:Kif18b UTSW 11 102908189 missense possibly damaging 0.89
R5820:Kif18b UTSW 11 102913048 missense probably benign 0.00
R5910:Kif18b UTSW 11 102913544 missense probably benign
R5912:Kif18b UTSW 11 102912991 missense probably benign
R6394:Kif18b UTSW 11 102914410 missense probably damaging 1.00
R6541:Kif18b UTSW 11 102914266 missense probably damaging 1.00
R6911:Kif18b UTSW 11 102916380 missense probably damaging 0.96
R7467:Kif18b UTSW 11 102916408 missense probably damaging 1.00
R7467:Kif18b UTSW 11 102912348 splice site probably null
R7526:Kif18b UTSW 11 102914667 missense probably damaging 1.00
R7581:Kif18b UTSW 11 102914722 missense probably damaging 1.00
R8378:Kif18b UTSW 11 102916473 missense probably damaging 1.00
RF013:Kif18b UTSW 11 102912366 missense probably benign 0.00
Z1088:Kif18b UTSW 11 102908157 missense probably benign
Predicted Primers
Posted On2020-07-28