Mutagenetix > Incidental Mutation

Incidental Mutation 'R8315:Or8c13'

641635

Institutional Source

Beutler Lab

Gene Symbol

Or8c13

Ensembl Gene

ENSMUSG00000045528

Gene Name

olfactory receptor family 8 subfamily C member 13

Synonyms

Olfr891, GA_x6K02T2PVTD-31862167-31861217, MOR170-9

MMRRC Submission

067720-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R8315 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

38091167-38092117 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 38091505 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 205 (T205A)

Ref Sequence

ENSEMBL: ENSMUSP00000055451 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062535]

AlphaFold

E9Q843

Predicted Effect

probably benign
Transcript: ENSMUST00000062535
AA Change: T205A

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000055451
Gene: ENSMUSG00000045528
AA Change: T205A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	1e-37	PFAM
Pfam:7tm_1	41	289	9.6e-12	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,328,460 (GRCm39)	E3511V	probably null	Het
Abca13	A	G	11: 9,535,502 (GRCm39)	T4709A	probably benign	Het
Aff1	G	T	5: 103,958,956 (GRCm39)	V342F	probably damaging	Het
Ahnak2	T	A	12: 112,745,756 (GRCm39)	Q1698L		Het
Ajap1	G	T	4: 153,516,813 (GRCm39)	T176K	probably damaging	Het
Alkal2	G	T	12: 30,934,850 (GRCm39)	G23V	probably damaging	Het
Cct3	A	G	3: 88,220,564 (GRCm39)	T259A	probably benign	Het
Cdk8	C	T	5: 146,205,061 (GRCm39)	L21F	probably damaging	Het
Cimip4	T	C	15: 78,262,686 (GRCm39)	R262G	probably benign	Het
Csf2rb	G	A	15: 78,231,581 (GRCm39)	G494D	possibly damaging	Het
Cstf3	G	T	2: 104,420,926 (GRCm39)		probably benign	Het
Cyp4f39	A	G	17: 32,701,176 (GRCm39)	D222G	probably benign	Het
Dcp2	T	C	18: 44,529,071 (GRCm39)	I62T	probably benign	Het
Dnaaf9	ATCCTCCTCCTCCTCCTCC	ATCCTCCTCCTCCTCC	2: 130,612,655 (GRCm39)		probably benign	Het
Dpp8	T	C	9: 64,988,133 (GRCm39)	*893Q	probably null	Het
Dpyd	A	T	3: 119,108,534 (GRCm39)	H859L	probably benign	Het
Dst	T	C	1: 34,323,501 (GRCm39)		probably null	Het
Dynlt2a2	A	G	17: 15,190,717 (GRCm39)	Y81H	probably damaging	Het
Egfr	A	G	11: 16,825,027 (GRCm39)	I456V	probably benign	Het
Elf3	A	G	1: 135,184,314 (GRCm39)	F185L	probably benign	Het
Emx1	A	G	6: 85,171,088 (GRCm39)	T164A	possibly damaging	Het
Fras1	G	A	5: 96,891,041 (GRCm39)	V2857M	probably damaging	Het
Gba2	AAAGAACCGTGTATACCGCCTGGGATGGAAAGAA	AAA	4: 43,569,937 (GRCm39)		probably null	Het
Gda	T	A	19: 21,394,435 (GRCm39)	T215S	probably benign	Het
Gm14443	C	T	2: 175,013,640 (GRCm39)		probably null	Het
Gpr152	C	T	19: 4,193,469 (GRCm39)	P337S	probably damaging	Het
H2-T10	A	G	17: 36,429,905 (GRCm39)	I296T	probably benign	Het
Hoxd11	G	A	2: 74,513,466 (GRCm39)	E244K	probably benign	Het
Inka1	C	A	9: 107,861,506 (GRCm39)	S270I	probably damaging	Het
Kazn	C	T	4: 141,869,002 (GRCm39)	D325N		Het
Lama2	T	C	10: 27,298,655 (GRCm39)	N147S	probably damaging	Het
Lamc1	A	T	1: 153,119,167 (GRCm39)	N817K	probably benign	Het
Met	T	C	6: 17,533,956 (GRCm39)	S636P	probably damaging	Het
Mrgpra3	A	T	7: 47,251,051 (GRCm39)	M1K	probably null	Het
Myh15	C	A	16: 48,940,381 (GRCm39)	T777N	probably damaging	Het
Or10ag2	C	A	2: 87,248,995 (GRCm39)	A201D	probably damaging	Het
Or6c209	G	A	10: 129,483,522 (GRCm39)	C175Y	probably benign	Het
Pbx2	A	G	17: 34,811,707 (GRCm39)	I60M	probably damaging	Het
Phf8-ps	C	A	17: 33,286,038 (GRCm39)	A255S	probably benign	Het
Pla2g4a	T	C	1: 149,761,965 (GRCm39)	N164S	probably benign	Het
Poln	A	G	5: 34,266,717 (GRCm39)	M480T	probably benign	Het
Ppp2r2a	T	C	14: 67,261,177 (GRCm39)	N181S	probably damaging	Het
Ppp3r2	A	C	4: 49,681,705 (GRCm39)	F82V	probably damaging	Het
Prox2	A	G	12: 85,142,182 (GRCm39)	V7A	probably benign	Het
Ptpn3	A	T	4: 57,270,063 (GRCm39)	I33K	possibly damaging	Het
Rad21l	A	T	2: 151,497,160 (GRCm39)	M318K	probably benign	Het
Rftn1	A	G	17: 50,309,665 (GRCm39)	S445P	possibly damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,229,130 (GRCm39)		probably benign	Het
Rtp4	C	T	16: 23,431,998 (GRCm39)	P177S	possibly damaging	Het
Saa4	T	A	7: 46,379,052 (GRCm39)	N96I	possibly damaging	Het
Shb	A	G	4: 45,489,079 (GRCm39)	Y266H	probably damaging	Het
Slc45a4	T	G	15: 73,461,405 (GRCm39)	Y88S	probably damaging	Het
Tbccd1	A	G	16: 22,641,564 (GRCm39)	M312T	probably damaging	Het
Tecta	C	T	9: 42,299,121 (GRCm39)		probably null	Het
Tle1	A	T	4: 72,044,428 (GRCm39)	C526*	probably null	Het
Tmem87a	C	T	2: 120,234,441 (GRCm39)	G34D	probably damaging	Het
Trav13d-1	C	A	14: 53,089,059 (GRCm39)	Q23K	probably benign	Het
Txndc11	G	T	16: 10,893,465 (GRCm39)	T755N	possibly damaging	Het
Vmn1r223	A	G	13: 23,434,339 (GRCm39)	D311G	probably damaging	Het
Vmn2r66	T	A	7: 84,643,932 (GRCm39)	Y826F	possibly damaging	Het
Wdr90	A	T	17: 26,064,399 (GRCm39)	M1824K	probably benign	Het
Zfp523	G	A	17: 28,421,562 (GRCm39)	G440D	possibly damaging	Het

Other mutations in Or8c13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02821:Or8c13	APN	9	38,091,964 (GRCm39)	missense	possibly damaging	0.65
IGL02987:Or8c13	APN	9	38,091,919 (GRCm39)	missense	possibly damaging	0.89
R0032:Or8c13	UTSW	9	38,091,904 (GRCm39)	missense	probably damaging	1.00
R1604:Or8c13	UTSW	9	38,091,645 (GRCm39)	missense	probably benign	0.12
R1678:Or8c13	UTSW	9	38,091,933 (GRCm39)	missense	possibly damaging	0.65
R2230:Or8c13	UTSW	9	38,091,442 (GRCm39)	missense	probably benign	0.00
R4391:Or8c13	UTSW	9	38,091,645 (GRCm39)	missense	probably damaging	0.99
R4470:Or8c13	UTSW	9	38,091,666 (GRCm39)	missense	probably damaging	0.96
R4803:Or8c13	UTSW	9	38,091,546 (GRCm39)	missense	probably damaging	1.00
R4865:Or8c13	UTSW	9	38,091,196 (GRCm39)	missense	possibly damaging	0.53
R5652:Or8c13	UTSW	9	38,092,111 (GRCm39)	missense	probably benign	0.01
R5743:Or8c13	UTSW	9	38,092,014 (GRCm39)	missense	probably benign
R7088:Or8c13	UTSW	9	38,091,748 (GRCm39)	missense	probably damaging	1.00
R7097:Or8c13	UTSW	9	38,091,632 (GRCm39)	nonsense	probably null
R7214:Or8c13	UTSW	9	38,091,318 (GRCm39)	missense	probably damaging	1.00
R7631:Or8c13	UTSW	9	38,092,002 (GRCm39)	missense	probably damaging	1.00
R8327:Or8c13	UTSW	9	38,091,186 (GRCm39)	missense	possibly damaging	0.72
R8894:Or8c13	UTSW	9	38,091,370 (GRCm39)	missense	probably damaging	1.00
R9055:Or8c13	UTSW	9	38,091,780 (GRCm39)	missense	probably damaging	1.00
R9325:Or8c13	UTSW	9	38,091,327 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AGGGATTCAGCAAAGGCACC -3'
(R):5'- TGATCATCACGTCTCCTATGACATG -3'

Sequencing Primer
(F):5'- GATTCAGCAAAGGCACCAAAAATG -3'
(R):5'- CCTATGACATGTTCCCTGATGATG -3'

Posted On

2020-07-28