Incidental Mutation 'R8317:Gpr63'
ID 641733
Institutional Source Beutler Lab
Gene Symbol Gpr63
Ensembl Gene ENSMUSG00000040372
Gene Name G protein-coupled receptor 63
Synonyms PSP24beta
MMRRC Submission 067721-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8317 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 24966407-25009233 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25008223 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 316 (T316S)
Ref Sequence ENSEMBL: ENSMUSP00000039312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038920]
AlphaFold Q9EQQ3
Predicted Effect probably damaging
Transcript: ENSMUST00000038920
AA Change: T316S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000039312
Gene: ENSMUSG00000040372
AA Change: T316S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 98 392 1.3e-8 PFAM
Pfam:7tm_1 104 377 1.9e-49 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 C T 13: 81,723,236 (GRCm39) V621M probably damaging Het
Adipor1 C T 1: 134,355,905 (GRCm39) R235W probably benign Het
Agbl1 T A 7: 76,071,929 (GRCm39) M594K unknown Het
Ang2 A G 14: 51,433,349 (GRCm39) V11A probably benign Het
Ccl25 A G 8: 4,404,138 (GRCm39) N80S probably benign Het
Cd19 A T 7: 126,012,615 (GRCm39) C259* probably null Het
Cd209b A T 8: 3,972,018 (GRCm39) I177N probably damaging Het
Cdc20 C A 4: 118,294,323 (GRCm39) probably benign Het
Cdh23 A T 10: 60,147,037 (GRCm39) probably null Het
Cdh23 G A 10: 60,272,568 (GRCm39) R536W probably damaging Het
Cfap299 A C 5: 98,885,459 (GRCm39) H122P probably benign Het
Chd6 T C 2: 160,832,241 (GRCm39) D977G probably damaging Het
Cilk1 T A 9: 78,060,933 (GRCm39) V193E probably damaging Het
Csl T G 10: 99,594,900 (GRCm39) H55P probably damaging Het
Cstf2t G A 19: 31,061,648 (GRCm39) A395T probably benign Het
Dhx58 A T 11: 100,594,388 (GRCm39) I101N probably damaging Het
Dlg5 A C 14: 24,241,298 (GRCm39) S200A probably damaging Het
Epb41 C A 4: 131,684,961 (GRCm39) G86V Het
Fat4 T C 3: 39,012,659 (GRCm39) V2318A possibly damaging Het
Fbxo32 A T 15: 58,068,626 (GRCm39) F119I probably damaging Het
Flacc1 T C 1: 58,715,707 (GRCm39) K170E possibly damaging Het
Fndc1 A T 17: 8,019,720 (GRCm39) L153* probably null Het
Foxp1 TTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG TTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG 6: 99,052,866 (GRCm39) probably benign Het
Gm4559 CTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAACAGCAGGGCTTGCAACAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCT CTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAACAGCAGGGCTTGCAACAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCT 7: 141,827,553 (GRCm39) probably benign Het
Il16 T C 7: 83,304,538 (GRCm39) T665A probably benign Het
Lama5 T C 2: 179,848,784 (GRCm39) N272S probably damaging Het
Map3k1 T C 13: 111,894,696 (GRCm39) Y660C probably damaging Het
Mbd3l1 C A 9: 18,396,117 (GRCm39) L81I probably benign Het
Morc3 C A 16: 93,659,417 (GRCm39) Q442K probably benign Het
Muc16 G A 9: 18,569,339 (GRCm39) T1060I unknown Het
Myh11 T A 16: 14,025,941 (GRCm39) D1343V Het
Myh15 C A 16: 48,940,381 (GRCm39) T777N probably damaging Het
Nbn T G 4: 15,970,893 (GRCm39) L292W probably damaging Het
Ndufb11b A G 15: 81,864,978 (GRCm39) Y73C probably damaging Het
Nebl A G 2: 17,355,568 (GRCm39) M195T possibly damaging Het
Net1 T C 13: 3,957,856 (GRCm39) K66E possibly damaging Het
Nod1 T C 6: 54,920,425 (GRCm39) Y631C probably damaging Het
Nxf1 A G 19: 8,748,407 (GRCm39) H12R probably benign Het
Onecut3 T C 10: 80,331,161 (GRCm39) L107P unknown Het
Opa1 T G 16: 29,432,962 (GRCm39) I512S probably damaging Het
P3h3 C T 6: 124,832,116 (GRCm39) G257R probably damaging Het
Pappa2 A G 1: 158,592,530 (GRCm39) C1616R probably damaging Het
Parn T G 16: 13,358,964 (GRCm39) K593Q probably damaging Het
Pcare A C 17: 72,056,197 (GRCm39) L1160R probably benign Het
Polr3g T C 13: 81,826,302 (GRCm39) K173R unknown Het
Prcp A G 7: 92,524,598 (GRCm39) T18A probably benign Het
Sash1 G A 10: 8,605,150 (GRCm39) T1080M possibly damaging Het
Skap2 A G 6: 51,884,865 (GRCm39) probably null Het
Spmip9 C A 6: 70,890,276 (GRCm39) W172L possibly damaging Het
Srebf1 C A 11: 60,091,483 (GRCm39) S1014I possibly damaging Het
Stk32b C T 5: 37,612,319 (GRCm39) E356K probably damaging Het
Tjp3 T A 10: 81,116,324 (GRCm39) T257S probably benign Het
Trf A G 9: 103,094,715 (GRCm39) Y448H probably damaging Het
Tsnaxip1 G C 8: 106,554,438 (GRCm39) R7P probably benign Het
Vmn1r208 G C 13: 22,956,947 (GRCm39) I183M probably benign Het
Vmn2r67 T A 7: 84,785,834 (GRCm39) M724L probably benign Het
Wdhd1 A T 14: 47,500,994 (GRCm39) H469Q probably damaging Het
Zbtb7a G C 10: 80,980,784 (GRCm39) G326A probably benign Het
Zfp493 G A 13: 67,931,958 (GRCm39) R19H probably benign Het
Zfp932 A T 5: 110,156,922 (GRCm39) K207* probably null Het
Other mutations in Gpr63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01576:Gpr63 APN 4 25,008,445 (GRCm39) missense possibly damaging 0.78
IGL01673:Gpr63 APN 4 25,008,014 (GRCm39) missense probably benign 0.04
IGL01861:Gpr63 APN 4 25,008,545 (GRCm39) missense probably damaging 0.98
IGL02082:Gpr63 APN 4 25,008,564 (GRCm39) utr 3 prime probably benign
R0003:Gpr63 UTSW 4 25,007,651 (GRCm39) missense probably damaging 1.00
R0554:Gpr63 UTSW 4 25,007,447 (GRCm39) missense probably benign
R0729:Gpr63 UTSW 4 25,007,480 (GRCm39) missense probably benign 0.02
R1506:Gpr63 UTSW 4 25,008,227 (GRCm39) missense probably damaging 1.00
R3103:Gpr63 UTSW 4 25,007,353 (GRCm39) missense probably benign 0.00
R3694:Gpr63 UTSW 4 25,007,993 (GRCm39) missense probably damaging 1.00
R4021:Gpr63 UTSW 4 25,008,470 (GRCm39) missense possibly damaging 0.77
R4807:Gpr63 UTSW 4 25,007,446 (GRCm39) missense probably benign
R4967:Gpr63 UTSW 4 25,008,368 (GRCm39) nonsense probably null
R5047:Gpr63 UTSW 4 25,008,202 (GRCm39) missense probably benign 0.44
R5325:Gpr63 UTSW 4 25,007,294 (GRCm39) missense probably benign 0.00
R5382:Gpr63 UTSW 4 25,007,952 (GRCm39) missense probably benign
R7047:Gpr63 UTSW 4 25,007,320 (GRCm39) missense probably benign 0.00
R7216:Gpr63 UTSW 4 25,008,038 (GRCm39) missense probably damaging 1.00
R8387:Gpr63 UTSW 4 25,008,301 (GRCm39) missense possibly damaging 0.64
R8989:Gpr63 UTSW 4 25,007,357 (GRCm39) missense possibly damaging 0.68
R9324:Gpr63 UTSW 4 25,008,432 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- ACAGTGCGTGTTTGGATACAC -3'
(R):5'- ATGCAGACTTGAGGTAGCAG -3'

Sequencing Primer
(F):5'- TGGATACACAACCAATTCTGGATAC -3'
(R):5'- TAGCAGAGCCAGAGTAGCC -3'
Posted On 2020-07-28