Incidental Mutation 'R8322:Vmn2r92'
ID 642043
Institutional Source Beutler Lab
Gene Symbol Vmn2r92
Ensembl Gene ENSMUSG00000091350
Gene Name vomeronasal 2, receptor 92
Synonyms EG627111
MMRRC Submission 067798-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8322 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 18372192-18405440 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18386886 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 75 (Y75C)
Ref Sequence ENSEMBL: ENSMUSP00000128685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169686]
AlphaFold L7N2A4
Predicted Effect probably damaging
Transcript: ENSMUST00000169686
AA Change: Y75C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: Y75C

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 83 463 4.7e-38 PFAM
Pfam:NCD3G 510 564 2.5e-19 PFAM
Pfam:7tm_3 597 832 1.1e-52 PFAM
low complexity region 843 855 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A G 8: 73,199,219 (GRCm39) S209G probably benign Het
Aars1 T C 8: 111,772,160 (GRCm39) L450P possibly damaging Het
Acsbg1 G A 9: 54,523,268 (GRCm39) T453M probably benign Het
Aff3 A G 1: 38,220,742 (GRCm39) S1100P possibly damaging Het
B4galt5 G A 2: 167,190,849 (GRCm39) A35V probably benign Het
C1qtnf1 T C 11: 118,338,683 (GRCm39) S118P probably benign Het
Ceacam20 A T 7: 19,705,628 (GRCm39) E206D probably damaging Het
Celsr3 T C 9: 108,725,993 (GRCm39) L3066P probably damaging Het
Cers3 T G 7: 66,439,386 (GRCm39) L299R probably damaging Het
Cfhr2 G T 1: 139,738,696 (GRCm39) H288Q probably benign Het
Cnot1 A T 8: 96,496,472 (GRCm39) M278K probably benign Het
Cnot10 T C 9: 114,456,537 (GRCm39) E166G probably damaging Het
Ctsd T A 7: 141,939,197 (GRCm39) D76V probably damaging Het
Cyp1a1 T A 9: 57,610,003 (GRCm39) F472L probably damaging Het
Dusp19 T A 2: 80,454,635 (GRCm39) D118E probably damaging Het
Dusp29 A T 14: 21,752,950 (GRCm39) D65E probably damaging Het
Eif2ak3 C A 6: 70,855,903 (GRCm39) R236S probably damaging Het
Fam169a A G 13: 97,259,260 (GRCm39) T439A probably benign Het
Flg T C 3: 93,191,639 (GRCm39) Y11H unknown Het
Fn1 T A 1: 71,667,618 (GRCm39) I792L probably benign Het
Fzd7 T C 1: 59,522,242 (GRCm39) S42P probably benign Het
Gimap3 A G 6: 48,742,370 (GRCm39) S187P possibly damaging Het
Gli1 C A 10: 127,167,477 (GRCm39) R592L probably damaging Het
Glt8d2 A T 10: 82,498,037 (GRCm39) I124N probably damaging Het
Hbp1 C T 12: 31,983,387 (GRCm39) D356N probably damaging Het
Hif1a T C 12: 73,986,373 (GRCm39) S367P probably benign Het
Hspg2 C G 4: 137,246,290 (GRCm39) P1023A possibly damaging Het
Itpr1 C A 6: 108,365,190 (GRCm39) N880K probably benign Het
Kank1 T C 19: 25,355,842 (GRCm39) probably benign Het
Kat2a T C 11: 100,603,116 (GRCm39) T39A unknown Het
Kcnk2 T A 1: 189,072,046 (GRCm39) Q98L probably benign Het
Kcnn4 G A 7: 24,083,545 (GRCm39) G409S probably benign Het
Klrb1 T A 6: 128,690,576 (GRCm39) I49F probably damaging Het
Larp4 G A 15: 99,908,237 (GRCm39) V573I probably benign Het
Lrpprc A G 17: 85,047,496 (GRCm39) probably null Het
Mybl1 A G 1: 9,746,506 (GRCm39) S385P probably damaging Het
Nup62 T C 7: 44,478,440 (GRCm39) S152P possibly damaging Het
Obi1 A T 14: 104,717,091 (GRCm39) D427E probably damaging Het
Or11a4 A G 17: 37,536,241 (GRCm39) Y75C probably damaging Het
Pcdh12 G A 18: 38,414,630 (GRCm39) Q832* probably null Het
Pcid2 A G 8: 13,128,555 (GRCm39) I368T probably damaging Het
Pcnx4 T A 12: 72,603,437 (GRCm39) F492I probably damaging Het
Pi4ka A G 16: 17,175,437 (GRCm39) Y464H Het
Plekhg5 T G 4: 152,189,201 (GRCm39) S260R possibly damaging Het
Prkdc T A 16: 15,532,005 (GRCm39) probably benign Het
Prr14 A T 7: 127,072,999 (GRCm39) E115D probably benign Het
Rab3gap2 A T 1: 184,978,877 (GRCm39) N285Y probably benign Het
Rhot1 T A 11: 80,148,386 (GRCm39) C609S possibly damaging Het
Rnf123 T C 9: 107,945,706 (GRCm39) Q360R probably benign Het
Rrp12 T C 19: 41,868,658 (GRCm39) T562A probably benign Het
Rundc1 G A 11: 101,322,992 (GRCm39) G317D probably benign Het
Rusf1 C T 7: 127,889,786 (GRCm39) R1H probably damaging Het
Slc14a1 A T 18: 78,145,656 (GRCm39) I426N possibly damaging Het
Slc23a1 C T 18: 35,755,588 (GRCm39) G436E probably damaging Het
Slc45a3 A G 1: 131,905,523 (GRCm39) D182G probably damaging Het
Sos1 A T 17: 80,715,728 (GRCm39) F1010I probably damaging Het
Tap1 A G 17: 34,412,163 (GRCm39) E456G probably damaging Het
Tha1 A T 11: 117,759,493 (GRCm39) V332E probably damaging Het
Tmem18 T A 12: 30,638,517 (GRCm39) I93N probably damaging Het
Tnrc18 A G 5: 142,711,767 (GRCm39) F2664S probably damaging Het
Tpm3 T A 3: 89,981,011 (GRCm39) probably benign Het
Ttc3 A G 16: 94,255,351 (GRCm39) E1615G probably damaging Het
Ube3b A G 5: 114,540,747 (GRCm39) T485A probably benign Het
Zfp169 T C 13: 48,644,575 (GRCm39) D184G unknown Het
Other mutations in Vmn2r92
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01591:Vmn2r92 APN 17 18,405,423 (GRCm39) missense unknown
IGL01758:Vmn2r92 APN 17 18,372,275 (GRCm39) nonsense probably null
IGL02614:Vmn2r92 APN 17 18,387,503 (GRCm39) splice site probably benign
IGL03095:Vmn2r92 APN 17 18,386,972 (GRCm39) missense possibly damaging 0.55
IGL03403:Vmn2r92 APN 17 18,387,114 (GRCm39) missense probably damaging 0.98
R0133:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0225:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0227:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0265:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0266:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0267:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0420:Vmn2r92 UTSW 17 18,389,183 (GRCm39) missense probably benign 0.01
R0426:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R0494:Vmn2r92 UTSW 17 18,388,219 (GRCm39) missense probably damaging 1.00
R1253:Vmn2r92 UTSW 17 18,387,028 (GRCm39) missense probably benign 0.08
R1497:Vmn2r92 UTSW 17 18,387,625 (GRCm39) missense probably benign 0.02
R1571:Vmn2r92 UTSW 17 18,372,352 (GRCm39) missense probably damaging 0.96
R1656:Vmn2r92 UTSW 17 18,372,198 (GRCm39) missense probably benign
R1816:Vmn2r92 UTSW 17 18,386,939 (GRCm39) missense probably damaging 0.98
R2229:Vmn2r92 UTSW 17 18,387,654 (GRCm39) missense probably benign 0.01
R2909:Vmn2r92 UTSW 17 18,405,377 (GRCm39) missense possibly damaging 0.89
R3694:Vmn2r92 UTSW 17 18,372,205 (GRCm39) nonsense probably null
R4207:Vmn2r92 UTSW 17 18,404,523 (GRCm39) missense possibly damaging 0.62
R4548:Vmn2r92 UTSW 17 18,391,578 (GRCm39) missense probably benign
R4612:Vmn2r92 UTSW 17 18,387,132 (GRCm39) missense probably benign 0.25
R4742:Vmn2r92 UTSW 17 18,387,119 (GRCm39) missense probably benign 0.06
R4824:Vmn2r92 UTSW 17 18,372,183 (GRCm39) utr 5 prime probably benign
R4865:Vmn2r92 UTSW 17 18,387,634 (GRCm39) missense probably benign 0.16
R4900:Vmn2r92 UTSW 17 18,404,605 (GRCm39) missense probably benign 0.27
R5084:Vmn2r92 UTSW 17 18,405,439 (GRCm39) makesense probably null
R5140:Vmn2r92 UTSW 17 18,372,312 (GRCm39) missense probably benign 0.07
R5995:Vmn2r92 UTSW 17 18,389,213 (GRCm39) critical splice donor site probably null
R6045:Vmn2r92 UTSW 17 18,388,305 (GRCm39) critical splice donor site probably null
R6269:Vmn2r92 UTSW 17 18,387,036 (GRCm39) missense probably benign 0.01
R6877:Vmn2r92 UTSW 17 18,389,084 (GRCm39) missense probably damaging 1.00
R7151:Vmn2r92 UTSW 17 18,387,005 (GRCm39) missense probably benign 0.01
R7260:Vmn2r92 UTSW 17 18,387,138 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r92 UTSW 17 18,387,513 (GRCm39) missense probably benign 0.01
R7514:Vmn2r92 UTSW 17 18,391,533 (GRCm39) missense probably damaging 1.00
R7576:Vmn2r92 UTSW 17 18,387,621 (GRCm39) missense probably benign 0.01
R7584:Vmn2r92 UTSW 17 18,387,028 (GRCm39) missense probably benign 0.08
R7912:Vmn2r92 UTSW 17 18,404,970 (GRCm39) missense possibly damaging 0.91
R7941:Vmn2r92 UTSW 17 18,405,099 (GRCm39) missense possibly damaging 0.89
R8178:Vmn2r92 UTSW 17 18,386,988 (GRCm39) missense possibly damaging 0.69
R8238:Vmn2r92 UTSW 17 18,405,278 (GRCm39) missense probably benign 0.00
R8239:Vmn2r92 UTSW 17 18,405,278 (GRCm39) missense probably benign 0.00
R8252:Vmn2r92 UTSW 17 18,387,134 (GRCm39) missense probably damaging 1.00
R8355:Vmn2r92 UTSW 17 18,405,061 (GRCm39) missense probably damaging 0.99
R9399:Vmn2r92 UTSW 17 18,389,137 (GRCm39) missense probably benign 0.29
R9639:Vmn2r92 UTSW 17 18,372,352 (GRCm39) missense probably damaging 0.96
R9747:Vmn2r92 UTSW 17 18,405,201 (GRCm39) missense possibly damaging 0.66
R9773:Vmn2r92 UTSW 17 18,386,949 (GRCm39) missense probably damaging 1.00
X0066:Vmn2r92 UTSW 17 18,405,157 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r92 UTSW 17 18,404,795 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCTTGCCTAAACCTAACGTATTC -3'
(R):5'- TGAGTGCAGCAGTGAAGGTTC -3'

Sequencing Primer
(F):5'- AACGTATTCATCTAATCTAGTTCAGC -3'
(R):5'- CAGCAGTGAAGGTTCTCTTTTTAC -3'
Posted On 2020-07-28