Incidental Mutation 'R8322:Or11a4'
ID 642045
Institutional Source Beutler Lab
Gene Symbol Or11a4
Ensembl Gene ENSMUSG00000064121
Gene Name olfactory receptor family 11 subfamily A member 4
Synonyms MOR121-1, Olfr96, GA_x6K02T2PSCP-1665046-1665987
MMRRC Submission 067798-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R8322 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 37535982-37537032 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37536241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 75 (Y75C)
Ref Sequence ENSEMBL: ENSMUSP00000077338 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078209]
AlphaFold Q8VFE3
Predicted Effect probably damaging
Transcript: ENSMUST00000078209
AA Change: Y75C

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000077338
Gene: ENSMUSG00000064121
AA Change: Y75C

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.6e-53 PFAM
Pfam:7tm_1 43 291 6.2e-22 PFAM
Meta Mutation Damage Score 0.5237 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A G 8: 73,199,219 (GRCm39) S209G probably benign Het
Aars1 T C 8: 111,772,160 (GRCm39) L450P possibly damaging Het
Acsbg1 G A 9: 54,523,268 (GRCm39) T453M probably benign Het
Aff3 A G 1: 38,220,742 (GRCm39) S1100P possibly damaging Het
B4galt5 G A 2: 167,190,849 (GRCm39) A35V probably benign Het
C1qtnf1 T C 11: 118,338,683 (GRCm39) S118P probably benign Het
Ceacam20 A T 7: 19,705,628 (GRCm39) E206D probably damaging Het
Celsr3 T C 9: 108,725,993 (GRCm39) L3066P probably damaging Het
Cers3 T G 7: 66,439,386 (GRCm39) L299R probably damaging Het
Cfhr2 G T 1: 139,738,696 (GRCm39) H288Q probably benign Het
Cnot1 A T 8: 96,496,472 (GRCm39) M278K probably benign Het
Cnot10 T C 9: 114,456,537 (GRCm39) E166G probably damaging Het
Ctsd T A 7: 141,939,197 (GRCm39) D76V probably damaging Het
Cyp1a1 T A 9: 57,610,003 (GRCm39) F472L probably damaging Het
Dusp19 T A 2: 80,454,635 (GRCm39) D118E probably damaging Het
Dusp29 A T 14: 21,752,950 (GRCm39) D65E probably damaging Het
Eif2ak3 C A 6: 70,855,903 (GRCm39) R236S probably damaging Het
Fam169a A G 13: 97,259,260 (GRCm39) T439A probably benign Het
Flg T C 3: 93,191,639 (GRCm39) Y11H unknown Het
Fn1 T A 1: 71,667,618 (GRCm39) I792L probably benign Het
Fzd7 T C 1: 59,522,242 (GRCm39) S42P probably benign Het
Gimap3 A G 6: 48,742,370 (GRCm39) S187P possibly damaging Het
Gli1 C A 10: 127,167,477 (GRCm39) R592L probably damaging Het
Glt8d2 A T 10: 82,498,037 (GRCm39) I124N probably damaging Het
Hbp1 C T 12: 31,983,387 (GRCm39) D356N probably damaging Het
Hif1a T C 12: 73,986,373 (GRCm39) S367P probably benign Het
Hspg2 C G 4: 137,246,290 (GRCm39) P1023A possibly damaging Het
Itpr1 C A 6: 108,365,190 (GRCm39) N880K probably benign Het
Kank1 T C 19: 25,355,842 (GRCm39) probably benign Het
Kat2a T C 11: 100,603,116 (GRCm39) T39A unknown Het
Kcnk2 T A 1: 189,072,046 (GRCm39) Q98L probably benign Het
Kcnn4 G A 7: 24,083,545 (GRCm39) G409S probably benign Het
Klrb1 T A 6: 128,690,576 (GRCm39) I49F probably damaging Het
Larp4 G A 15: 99,908,237 (GRCm39) V573I probably benign Het
Lrpprc A G 17: 85,047,496 (GRCm39) probably null Het
Mybl1 A G 1: 9,746,506 (GRCm39) S385P probably damaging Het
Nup62 T C 7: 44,478,440 (GRCm39) S152P possibly damaging Het
Obi1 A T 14: 104,717,091 (GRCm39) D427E probably damaging Het
Pcdh12 G A 18: 38,414,630 (GRCm39) Q832* probably null Het
Pcid2 A G 8: 13,128,555 (GRCm39) I368T probably damaging Het
Pcnx4 T A 12: 72,603,437 (GRCm39) F492I probably damaging Het
Pi4ka A G 16: 17,175,437 (GRCm39) Y464H Het
Plekhg5 T G 4: 152,189,201 (GRCm39) S260R possibly damaging Het
Prkdc T A 16: 15,532,005 (GRCm39) probably benign Het
Prr14 A T 7: 127,072,999 (GRCm39) E115D probably benign Het
Rab3gap2 A T 1: 184,978,877 (GRCm39) N285Y probably benign Het
Rhot1 T A 11: 80,148,386 (GRCm39) C609S possibly damaging Het
Rnf123 T C 9: 107,945,706 (GRCm39) Q360R probably benign Het
Rrp12 T C 19: 41,868,658 (GRCm39) T562A probably benign Het
Rundc1 G A 11: 101,322,992 (GRCm39) G317D probably benign Het
Rusf1 C T 7: 127,889,786 (GRCm39) R1H probably damaging Het
Slc14a1 A T 18: 78,145,656 (GRCm39) I426N possibly damaging Het
Slc23a1 C T 18: 35,755,588 (GRCm39) G436E probably damaging Het
Slc45a3 A G 1: 131,905,523 (GRCm39) D182G probably damaging Het
Sos1 A T 17: 80,715,728 (GRCm39) F1010I probably damaging Het
Tap1 A G 17: 34,412,163 (GRCm39) E456G probably damaging Het
Tha1 A T 11: 117,759,493 (GRCm39) V332E probably damaging Het
Tmem18 T A 12: 30,638,517 (GRCm39) I93N probably damaging Het
Tnrc18 A G 5: 142,711,767 (GRCm39) F2664S probably damaging Het
Tpm3 T A 3: 89,981,011 (GRCm39) probably benign Het
Ttc3 A G 16: 94,255,351 (GRCm39) E1615G probably damaging Het
Ube3b A G 5: 114,540,747 (GRCm39) T485A probably benign Het
Vmn2r92 A G 17: 18,386,886 (GRCm39) Y75C probably damaging Het
Zfp169 T C 13: 48,644,575 (GRCm39) D184G unknown Het
Other mutations in Or11a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Or11a4 APN 17 37,536,043 (GRCm39) missense probably benign 0.05
IGL02151:Or11a4 APN 17 37,536,057 (GRCm39) missense probably damaging 1.00
IGL02335:Or11a4 APN 17 37,536,217 (GRCm39) missense probably damaging 0.97
R0360:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R0364:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R1763:Or11a4 UTSW 17 37,536,321 (GRCm39) missense probably benign 0.02
R3977:Or11a4 UTSW 17 37,536,049 (GRCm39) missense probably benign 0.24
R6116:Or11a4 UTSW 17 37,536,459 (GRCm39) missense probably benign 0.00
R6248:Or11a4 UTSW 17 37,536,451 (GRCm39) nonsense probably null
R6378:Or11a4 UTSW 17 37,536,688 (GRCm39) missense probably benign 0.21
R6518:Or11a4 UTSW 17 37,536,159 (GRCm39) missense probably benign 0.05
R6614:Or11a4 UTSW 17 37,536,790 (GRCm39) missense probably benign 0.01
R6798:Or11a4 UTSW 17 37,536,697 (GRCm39) missense probably damaging 1.00
R6874:Or11a4 UTSW 17 37,536,238 (GRCm39) missense probably benign 0.00
R7468:Or11a4 UTSW 17 37,536,276 (GRCm39) missense probably benign 0.01
R7820:Or11a4 UTSW 17 37,536,786 (GRCm39) missense probably benign 0.00
R7852:Or11a4 UTSW 17 37,536,163 (GRCm39) missense probably benign 0.01
R8481:Or11a4 UTSW 17 37,536,295 (GRCm39) missense probably damaging 1.00
R8933:Or11a4 UTSW 17 37,536,346 (GRCm39) missense possibly damaging 0.96
X0027:Or11a4 UTSW 17 37,536,634 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GGTTTCCATGAAGTCCCTGG -3'
(R):5'- GTCCATCTACCATGAAGCCAG -3'

Sequencing Primer
(F):5'- ATGAAGTCCCTGGGCTGCAC -3'
(R):5'- ACCATTGAGGCCCCATGAG -3'
Posted On 2020-07-28