Mutagenetix > Incidental Mutation

Incidental Mutation 'BB006:Vmn2r107'

642380

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

BB006

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 20345444 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 7 (I7S)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably null
Transcript: ENSMUST00000042090
AA Change: I7S

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: I7S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Meta Mutation Damage Score

0.9756

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410137M14Rik	T	A	17: 36,978,520	I105F	possibly damaging	Het
Adprhl1	C	T	8: 13,248,682	V83I	probably damaging	Het
Adra1d	G	T	2: 131,561,680	C163*	probably null	Het
AI314180	A	G	4: 58,869,554	C238R	probably damaging	Het
Ak9	A	G	10: 41,383,948	D874G		Het
Akap8	A	T	17: 32,309,445	S498T	probably damaging	Het
Alyref2	C	G	1: 171,503,839	F61L	probably benign	Het
Ank1	A	T	8: 23,116,107	I1172F	probably damaging	Het
Ankrd50	A	T	3: 38,457,109	F370I	probably damaging	Het
Apip	A	C	2: 103,083,021	T41P	probably benign	Het
Atg4d	G	A	9: 21,266,964	R126Q	probably null	Het
Ccdc129	G	A	6: 55,897,961	V299M	probably damaging	Het
Ccdc86	A	G	19: 10,948,819	S139P	unknown	Het
Ceacam16	A	G	7: 19,853,631	L404P	probably damaging	Het
Dennd3	G	T	15: 73,564,574	V1010L	probably damaging	Het
Disp1	A	G	1: 183,135,539	S108P	probably benign	Het
Ephb2	A	G	4: 136,660,884	V635A	probably damaging	Het
G530012D18Rik	C	G	1: 85,577,214	D113E	unknown	Het
Gars	A	G	6: 55,063,117	H343R	probably damaging	Het
Gli2	A	T	1: 118,842,042	N593K	possibly damaging	Het
Il18rap	T	A	1: 40,531,580	N227K	probably damaging	Het
Il4ra	T	C	7: 125,575,176	S297P	probably benign	Het
Jak1	A	T	4: 101,154,645	F1087I	probably damaging	Het
Klf16	A	G	10: 80,576,864	S113P	probably benign	Het
Klhl30	A	T	1: 91,355,516	E280V	possibly damaging	Het
Kti12	A	C	4: 108,848,246	E119A	probably benign	Het
Kti12	G	T	4: 108,848,247	E119D	probably benign	Het
Lama4	A	G	10: 39,078,847	H1132R	probably damaging	Het
Lmtk3	A	G	7: 45,795,148	D1085G	unknown	Het
Lrrc9	C	A	12: 72,486,297	T980K	possibly damaging	Het
Nceh1	A	G	3: 27,279,247	D164G	probably benign	Het
Nlrp2	A	G	7: 5,327,499	S633P	probably damaging	Het
Nxn	A	G	11: 76,274,037	V216A	possibly damaging	Het
Odf4	A	T	11: 68,922,933	V143D	possibly damaging	Het
Olfr1428	G	A	19: 12,108,754	T38I	unknown	Het
Pex12	A	G	11: 83,297,983	I62T	probably damaging	Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 109,624,195		probably benign	Het
Plekhg1	G	A	10: 3,919,170	D237N	probably damaging	Het
Rxrb	T	A	17: 34,036,671	D377E	probably benign	Het
Ryr2	T	A	13: 11,594,794	D4382V	probably damaging	Het
Ryr2	T	A	13: 11,690,295	K2862*	probably null	Het
Ryr3	A	G	2: 112,834,188	L1606P	probably benign	Het
Samd3	A	G	10: 26,251,915	K270R	probably damaging	Het
Slc2a5	C	A	4: 150,139,485	F211L	probably benign	Het
Spata31	T	A	13: 64,921,718	V560D	probably benign	Het
Tbk1	A	G	10: 121,557,233	C471R	probably benign	Het
Tbx20	A	T	9: 24,725,763	S343T	possibly damaging	Het
Tesk2	A	G	4: 116,802,255	E304G	probably benign	Het
Tle1	A	G	4: 72,200,002	F2L	possibly damaging	Het
Tle4	G	T	19: 14,517,880	P162T	probably benign	Het
Ttn	G	A	2: 76,843,472	P11172S	unknown	Het
Tulp1	T	C	17: 28,353,772	N470S	possibly damaging	Het
Unc13b	A	G	4: 43,174,399	I1742M	unknown	Het
Vmn2r91	T	G	17: 18,107,644	I500R	probably damaging	Het
Xpnpep3	A	G	15: 81,427,425	I111V	probably damaging	Het
Zp3r	T	A	1: 130,591,480	E308V	probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- CCCAATGGCATTTCTGAACCC -3'
(R):5'- GGCTACACCCATTACGTCATAAG -3'

Sequencing Primer
(F):5'- CTGAACCCTTGGAATATTTGTGTC -3'
(R):5'- CACCCATTACGTCATAAGAATTCTG -3'

Posted On

2020-08-01