Incidental Mutation 'R0051:Dpp7'
Institutional Source Beutler Lab
Gene Symbol Dpp7
Ensembl Gene ENSMUSG00000026958
Gene Namedipeptidylpeptidase 7
MMRRC Submission 038345-MU
Accession Numbers

Genbank: NM_031843.2; Ensembl: ENSMUST00000028332

Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #R0051 (G1)
Quality Score163
Status Validated
Chromosomal Location25352276-25356359 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 25356095 bp
Amino Acid Change Tyrosine to Histidine at position 49 (Y49H)
Ref Sequence ENSEMBL: ENSMUSP00000028332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028332] [ENSMUST00000042390] [ENSMUST00000102925]
Predicted Effect possibly damaging
Transcript: ENSMUST00000028332
AA Change: Y49H

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000028332
Gene: ENSMUSG00000026958
AA Change: Y49H

signal peptide 1 33 N/A INTRINSIC
Pfam:Peptidase_S28 48 475 2.3e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042390
SMART Domains Protein: ENSMUSP00000036996
Gene: ENSMUSG00000036646

low complexity region 3 11 N/A INTRINSIC
low complexity region 29 42 N/A INTRINSIC
transmembrane domain 49 71 N/A INTRINSIC
Pfam:Glyco_hydro_47 215 654 9.5e-167 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102925
SMART Domains Protein: ENSMUSP00000099989
Gene: ENSMUSG00000026956

low complexity region 24 48 N/A INTRINSIC
Pfam:UDPGP 68 453 2.1e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125248
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131665
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135473
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139108
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139971
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144218
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149953
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150305
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.8%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A G 7: 29,579,101 noncoding transcript Het
Abr T A 11: 76,472,502 Q163L probably benign Het
AI314180 A G 4: 58,832,729 L877S probably damaging Het
Ankrd11 C A 8: 122,889,742 C2457F probably damaging Het
Anks3 G C 16: 4,947,749 T163S probably benign Het
Cacna1d G A 14: 30,111,095 P908S probably damaging Het
Ccdc146 C A 5: 21,316,904 R374L possibly damaging Het
Cdc45 G T 16: 18,794,774 A348E probably damaging Het
Cfap46 A G 7: 139,676,035 C300R probably damaging Het
Coq2 T C 5: 100,663,685 N146S probably benign Het
Dalrd3 T C 9: 108,572,215 V120A possibly damaging Het
Dcp2 T A 18: 44,405,374 probably benign Het
Ddx39 A G 8: 83,720,622 K137R possibly damaging Het
Diaph3 A G 14: 87,037,454 probably null Het
Dmbt1 G T 7: 131,119,496 R1668L possibly damaging Het
Dnah7a T G 1: 53,521,086 probably benign Het
Drd5 A G 5: 38,320,614 S317G probably benign Het
Ecsit C T 9: 22,076,288 V152I probably benign Het
Emc1 T A 4: 139,375,163 M923K possibly damaging Het
Fam102a G A 2: 32,558,053 R58Q possibly damaging Het
Fcrl6 A T 1: 172,598,753 L159Q probably benign Het
Frrs1 T C 3: 116,885,297 probably benign Het
Hspd1 A G 1: 55,082,046 probably benign Het
Impg2 T A 16: 56,258,048 S458T probably damaging Het
Klf17 T C 4: 117,760,392 Y256C probably damaging Het
Lnx2 A G 5: 147,029,353 F319L probably damaging Het
Mafg G T 11: 120,629,604 R57S probably damaging Het
Med13l T A 5: 118,742,655 W1271R probably damaging Het
Mrgprb1 A G 7: 48,447,214 S24P probably benign Het
Mtrf1l T C 10: 5,813,384 E315G probably damaging Het
Naip1 T C 13: 100,411,001 E1239G probably damaging Het
Ncaph2 T C 15: 89,369,664 S320P probably damaging Het
Nek11 A G 9: 105,218,539 probably benign Het
Nlrp2 A T 7: 5,322,334 probably benign Het
Odf3 C A 7: 140,850,221 probably benign Het
Rbm26 A C 14: 105,152,540 V216G possibly damaging Het
Rnf115 A G 3: 96,785,022 D178G probably damaging Het
Rtel1 C T 2: 181,350,656 Q424* probably null Het
Rwdd4a A G 8: 47,537,365 probably benign Het
Ryr3 T C 2: 112,869,075 D890G probably damaging Het
Scarb1 C A 5: 125,281,100 probably null Het
Serpina10 A G 12: 103,626,897 probably benign Het
Slc12a5 T A 2: 164,986,663 W508R probably damaging Het
Slc43a2 T C 11: 75,562,850 C225R probably damaging Het
Slc6a9 T C 4: 117,864,859 F440L probably damaging Het
Stac3 G A 10: 127,508,148 R305H probably damaging Het
Stk32b A G 5: 37,459,596 probably benign Het
Syna A T 5: 134,559,543 L184H probably damaging Het
Tmprss7 T C 16: 45,673,939 N401S probably damaging Het
Yeats2 T A 16: 20,193,724 Y557* probably null Het
Zcchc11 T G 4: 108,527,004 S1089R probably damaging Het
Zfp352 T C 4: 90,224,285 S221P probably damaging Het
Zfp575 A G 7: 24,586,087 V43A probably benign Het
Zfp775 A G 6: 48,620,772 T527A probably benign Het
Other mutations in Dpp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Dpp7 APN 2 25354613 missense probably benign 0.01
IGL02897:Dpp7 APN 2 25353672 missense probably damaging 1.00
IGL02992:Dpp7 APN 2 25354577 missense possibly damaging 0.65
IGL03069:Dpp7 APN 2 25355723 critical splice acceptor site probably null
1mM(1):Dpp7 UTSW 2 25356140 missense probably benign 0.05
PIT4519001:Dpp7 UTSW 2 25352448 missense probably damaging 0.97
R0051:Dpp7 UTSW 2 25356095 missense possibly damaging 0.80
R0900:Dpp7 UTSW 2 25356299 missense probably damaging 0.99
R1889:Dpp7 UTSW 2 25353679 splice site probably null
R1895:Dpp7 UTSW 2 25353679 splice site probably null
R2055:Dpp7 UTSW 2 25354478 missense possibly damaging 0.84
R4697:Dpp7 UTSW 2 25354919 missense probably benign 0.00
R4832:Dpp7 UTSW 2 25352386 unclassified probably benign
R4887:Dpp7 UTSW 2 25352758 critical splice acceptor site probably null
R5114:Dpp7 UTSW 2 25352737 missense possibly damaging 0.51
R6976:Dpp7 UTSW 2 25354824 critical splice acceptor site probably null
R7577:Dpp7 UTSW 2 25355591 missense probably benign
R8459:Dpp7 UTSW 2 25352538 missense probably damaging 1.00
R8486:Dpp7 UTSW 2 25352549 missense probably damaging 1.00
R8672:Dpp7 UTSW 2 25356121 missense probably benign 0.00
R8690:Dpp7 UTSW 2 25355633 missense probably damaging 1.00
X0058:Dpp7 UTSW 2 25354752 missense probably benign 0.05
Predicted Primers PCR Primer

Sequencing Primer
Posted On2013-08-06